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Submit ReviewUA 62784
Description: Inhibits microtubule polymerization
Chemical Name: 4-[5-(4-Methoxyphenyl)-2-oxazolyl]-9H-fluoren-9-one
Purity: ≥99% (HPLC)
Biological Activity for UA 62784
UA 62784 is an inhibitor of microtubule polymerization in vitro. Interacts with tubulin dimers and promotes the accumulation of mammalian cells in apoptosis. Potentiates antiproliferative effects of vinblastine (Cat. No. 1256) in H2B-GFP HeLa cells. Originally thought to inhibit CENP-E ATPase activity.
Technical Data for UA 62784
| M. Wt | 353.37 |
| Formula | C23H15NO3 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 313367-92-9 |
| PubChem ID | 3383533 |
| InChI Key | SVICLWPFAQYZLX-UHFFFAOYSA-N |
| Smiles | O=C2C1=CC=CC(C4=NC=C(C5=CC=C(OC)C=C5)O4)=C1C3=C2C=CC=C3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for UA 62784
References for UA 62784
References are publications that support the biological activity of the product.
Tcherniuk et al (2011) UA62784 is a cytotoxic inhibitor of microtubules, not CENP-E. Chem.Biol. 18 631 PMID: 21609844
Maiato and Logarinho et al (2011) Motor-dependent and -independent roles of CENP-E at kinetochores: the cautionary tale of UA62784. Chem.Biol. 18 679 PMID: 21700202
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Keywords: UA 62784, UA 62784 supplier, UA62784, cytotoxic, antiproliferatives, microtubules, inhibitors, inhibits, polymerization, polymerisation, Microtubules, 4286, Tocris Bioscience
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Cell Cycle and DNA Damage Research Product Guide
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