UA 62784

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Cat.No. 4286 - UA 62784 | C23H15NO3 | CAS No. 313367-92-9
Description: Inhibits microtubule polymerization
Chemical Name: 4-[5-(4-Methoxyphenyl)-2-oxazolyl]-9H-fluoren-9-one
Purity: ≥99% (HPLC)
Literature (2)

Biological Activity

Inhibitor of microtubule polymerization in vitro. Interacts with tubulin dimers and promotes the accumulation of mammalian cells in apoptosis. Potentiates antiproliferative effects of vinblastine (Cat. No. 1256) in H2B-GFP HeLa cells. Originally thought to inhibit CENP-E ATPase activity.

Technical Data

M. Wt 353.37
Formula C23H15NO3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 313367-92-9
PubChem ID 3383533
Smiles O=C2C1=CC=CC(C4=NC=C(C5=CC=C(OC)C=C5)O4)=C1C3=C2C=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 8.83 25

Preparing Stock Solutions

The following data is based on the product molecular weight 353.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 11.32 mL 56.6 mL 113.2 mL
1.25 mM 2.26 mL 11.32 mL 22.64 mL
2.5 mM 1.13 mL 5.66 mL 11.32 mL
12.5 mM 0.23 mL 1.13 mL 2.26 mL

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References are publications that support the biological activity of the product.

Tcherniuk et al (2011) UA62784 is a cytotoxic inhibitor of microtubules, not CENP-E. Chem.Biol. 18 631 PMID: 21609844

Maiato and Logarinho et al (2011) Motor-dependent and -independent roles of CENP-E at kinetochores: the cautionary tale of UA62784. Chem.Biol. 18 679 PMID: 21700202

If you know of a relevant reference for UA 62784, please let us know.

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Keywords: UA 62784, UA 62784 supplier, UA62784, cytotoxic, antiproliferatives, microtubules, inhibitors, inhibits, polymerization, polymerisation, Microtubules, 4286, Tocris Bioscience

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