U 92016A

Discontinued Product

Unfortunately U 92016A (Cat. No. 2739) has been withdrawn from sale for commercial reasons.
Cat.No. 2739 - U 92016A | C19H25N3.HCl | CAS No. 149654-41-1
Description: Selective 5-HT1A agonist
Chemical Name: (8R)-8-(Dipropylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-2-carbonitrile hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective 5-HT1A receptor agonist that displays high intrinsic activity (Ki values are 0.4, 7.7 and 36 nM for 5-HT1A, 5-HT1D and D2 receptors respectively and > 1000 nM for 5-HT2, D1, α1 and α2 receptors). Produces hypothermia, hypotension and 5-HT behavioral syndrome following p.o. administration.

Technical Data

M. Wt 331.88
Formula C19H25N3.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 149654-41-1
Smiles CCCN(CCC)[C@@H]1CCC(C=CC3=C2C=C(C#N)N3)=C2C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 331.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.01 mL 15.07 mL 30.13 mL
5 mM 0.6 mL 3.01 mL 6.03 mL
10 mM 0.3 mL 1.51 mL 3.01 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Romero et al (1993) Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants. J.Med.Chem. 36 2066 PMID: 8101876

McCall et al (1994) Characterization of U-92016A as a selective, orally active, high intrinsic activity 5-hydroxytryptamine1A agonist. J.Pharmacol.Exp.Ther. 271 875 PMID: 7965808

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Keywords: Selective 5-HT1A agonists Serotonin Receptors U92016A 5-HT1A Receptors

Citations for U 92016A

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5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

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Pathways for U 92016A

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