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Submit ReviewU 92016A
Discontinued Product
U 92016A (Cat. No. 2739) has been withdrawn from sale for commercial reasons.
Description: Selective 5-HT1A agonist
Chemical Name: (8R)-8-(Dipropylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-2-carbonitrile hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for U 92016A
Selective 5-HT1A receptor agonist that displays high intrinsic activity (Ki values are 0.4, 7.7 and 36 nM for 5-HT1A, 5-HT1D and D2 receptors respectively and > 1000 nM for 5-HT2, D1, α1 and α2 receptors). Produces hypothermia, hypotension and 5-HT behavioral syndrome following p.o. administration.
Technical Data for U 92016A
| M. Wt | 331.88 |
| Formula | C19H25N3.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 149654-41-1 |
| Smiles | CCCN(CCC)[C@@H]1CCC(C=CC3=C2C=C(C#N)N3)=C2C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for U 92016A
References for U 92016A
References are publications that support the biological activity of the product.
Romero et al (1993) Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants. J.Med.Chem. 36 2066 PMID: 8101876
McCall et al (1994) Characterization of U-92016A as a selective, orally active, high intrinsic activity 5-hydroxytryptamine1A agonist. J.Pharmacol.Exp.Ther. 271 875 PMID: 7965808
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Keywords: U 92016A, U 92016A supplier, Selective, 5-HT1A, agonists, Serotonin, Receptors, U92016A, 2739, Tocris Bioscience
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