U-54494A hydrochloride

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Cat.No. 0498 - U-54494A hydrochloride | C18H24Cl2N2O.HCl | CAS No. 112465-94-8
Description: κ agonist
Chemical Name: cis-(±)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzamide hydrochloride

Biological Activity

κ-opioid agonist and anticonvulsant. Perhaps acts as an NMDA antagonist.

Technical Data

M. Wt 391.77
Formula C18H24Cl2N2O.HCl
Storage Store at RT
CAS Number 112465-94-8
PubChem ID 183470
Smiles O=C(C3=CC(Cl)=C(Cl)C=C3)N([C@H]1[C@@H](N2CCCC2)CCCC1)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 39.18 100

Preparing Stock Solutions

The following data is based on the product molecular weight 391.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.76 mL 25.53 mL
5 mM 0.51 mL 2.55 mL 5.11 mL
10 mM 0.26 mL 1.28 mL 2.55 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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Product Datasheets

Certificate of Analysis is currently unavailable
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Safety Datasheet


References are publications that support the products' biological activity.

Proietti et al (1991) In vitro depressant effects of U-54494A, an anticonvulsant related to kappa opioids in the hippocampus. Neuropharmacology 30 637 PMID: 1656303

Sethy and Sage (1992) Modulation of release of acetylcholine from the striatum by a proposed excitatory amino acid antagonist U-54494A: comparison with known antagonists, diazepam and phenytoin. Neuropharmacology 31 111 PMID: 1348110

Voigtlander et al (1987) U-54494A: a unique anticonvulsant related to kappa opioid agonists. J.Pharmacol.Exp.Ther. 243 542 PMID: 2824750

If you know of a relevant reference for U-54494A hydrochloride, please let us know.

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Keywords: U-54494A hydrochloride, supplier, agonists, κ-opioid, kappa-opioid, KOP, Receptors, OP2, Kappa, Opioid, Receptors, Kappa, Opioid, Receptors, Tocris Bioscience

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