Tropisetron hydrochloride

Pricing Availability   Qty
Description: Potent 5-HT3 antagonist; also α7 nAChR partial agonist
Alternative Names: Novaban, ICS 205930
Chemical Name: (3-endo)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 1H-indole-3-carboxylic acid ester monohydrochloride
Purity: ≥99% (HPLC)
Citations (4)
Literature (1)

Biological Activity for Tropisetron hydrochloride

Tropisetron hydrochloride is a potent, orally active 5-HT3 receptor antagonist. Antiemetic. Also partial agonist of α7 nAChR. Activates α7Q79G-GlyR chimeric ion channels (EC50 = 38 nM)

Technical Data for Tropisetron hydrochloride

M. Wt 320.82
Formula C17H20N2O2.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 105826-92-4
PubChem ID 656664
Smiles O=C(O[C@@H]3C[C@@H]4CC[C@@H](N4C)C3)C2=CNC1=CC=CC=C12.O=C(O[C@@H]7C[C@H]8CC[C@H](N8C)C7)C6=CNC5=CC=CC=C56.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Tropisetron hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 32.08 100
DMSO 16.04 50

Preparing Stock Solutions for Tropisetron hydrochloride

The following data is based on the product molecular weight 320.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.12 mL 15.59 mL 31.17 mL
5 mM 0.62 mL 3.12 mL 6.23 mL
10 mM 0.31 mL 1.56 mL 3.12 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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Product Datasheets for Tropisetron hydrochloride

Certificate of Analysis / Product Datasheet
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References for Tropisetron hydrochloride

References are publications that support the biological activity of the product.

Seynaeve et al (1991) 5-HT3 receptor antagonists, a new approach in emesis: a review of ondansetron, granis. and tropisetron. Anticancer Drugs 2 343 PMID: 1665723

Middlemiss and Tricklebank (1992) Centrally active 5-HT receptor agonists and antagonists. Neurosci.Biobehav.Rev. 16 75 PMID: 1553108

Mhatre et al (2004) 5-HT3 antagonist ICS 205-930 enhances naltrexone's effects on ethanol intake. Eur.J.Pharmacol. 491 149 PMID: 15140631

Papke et al (2004) Activity of α7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes. Bioorg.Med.Chem.Lett. 14 1849 PMID: 15050614

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4 Citations for Tropisetron hydrochloride

Citations are publications that use Tocris products. Selected citations for Tropisetron hydrochloride include:

Sendin et al (2014) Spatiotemporal pattern of action potential firing in developing inner hair cells of the mouse cochlea. Mol Cell Biol 111 1999 PMID: 24429348

Otvos et al (2015) Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms. Respir Physiol Neurobiol 7 2336 PMID: 26114334

Johnson et al (2015) Hypoxia switches episodic breathing to singlet breathing in red-eared slider turtles (Trachemys scripta) via a tropisetron-sensitive mechanism. Proc Natl Acad Sci U S A 207 48 PMID: 25543027

Spilman et al (2014) The multi-functional drug tropisetron binds APP and normalizes cognition in a murine Alzheimer's model. Brain Res 1551 25 PMID: 24389031

Do you know of a great paper that uses Tropisetron hydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.