Tropisetron hydrochloride

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Cat.No. 2459 - Tropisetron hydrochloride | C17H20N2O2.HCl | CAS No. 105826-92-4
Description: Potent 5-HT3 receptor antagonist; also partial agonist of α7 nAChR
Alternative Names: Novaban, ICS 205930
Chemical Name: (3-endo)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 1H-indole-3-carboxylic acid ester monohydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (4)
Literature

Biological Activity

Potent, orally active 5-HT3 receptor antagonist. Antiemetic. Also partial agonist of α7 nAChR.

Technical Data

M. Wt 320.82
Formula C17H20N2O2.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 105826-92-4
PubChem ID 656664
InChI Key XIEGSJAEZIGKSA-KOQCZNHOSA-N
Smiles O=C(O[C@@H]3C[C@@H]4CC[C@@H](N4C)C3)C2=CNC1=CC=CC=C12.O=C(O[C@@H]7C[C@H]8CC[C@H](N8C)C7)C6=CNC5=CC=CC=C56.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 16.04 50
water 32.08 100

Preparing Stock Solutions

The following data is based on the product molecular weight 320.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.12 mL 15.59 mL 31.17 mL
5 mM 0.62 mL 3.12 mL 6.23 mL
10 mM 0.31 mL 1.56 mL 3.12 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Seynaeve et al (1991) 5-HT3 receptor antagonists, a new approach in emesis: a review of ondansetron, granisetron and tropisetron. Anticancer Drugs 2 343 PMID: 1665723

Middlemiss and Tricklebank (1992) Centrally active 5-HT receptor agonists and antagonists. Neurosci.Biobehav.Rev. 16 75 PMID: 1553108

Mhatre et al (2004) 5-HT3 antagonist ICS 205-930 enhances naltrexone's effects on ethanol intake. Eur.J.Pharmacol. 491 149 PMID: 15140631

Papke et al (2004) Activity of α7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes. Bioorg.Med.Chem.Lett. 14 1849 PMID: 15050614


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View all 5-HT3 Receptor Antagonists

Keywords: Tropisetron hydrochloride, supplier, Potent, 5-HT3, receptor, antagonists, orally, active, Serotonin, Receptors, ICS205930, Nicotinics, nAChRs, alpha7, a7, α7, partial, agonists, Navoban, ICS, 205930, 5-HT3, Receptors, Nicotinic, (a7), Receptors, 5-HT3, Receptors, Tocris Bioscience

4 Citations for Tropisetron hydrochloride

Citations are publications that use Tocris products. Selected citations for Tropisetron hydrochloride include:

Sendin et al (2014) Spatiotemporal pattern of action potential firing in developing inner hair cells of the mouse cochlea. Mol Cell Biol 111 1999 PMID: 24429348

Otvos et al (2015) Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms. Respir Physiol Neurobiol 7 2336 PMID: 26114334

Johnson et al (2015) Hypoxia switches episodic breathing to singlet breathing in red-eared slider turtles (Trachemys scripta) via a tropisetron-sensitive mechanism. Proc Natl Acad Sci U S A 207 48 PMID: 25543027

Spilman et al (2014) The multi-functional drug tropisetron binds APP and normalizes cognition in a murine Alzheimer's model. Brain Res 1551 25 PMID: 24389031


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Literature in this Area

5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.