Discontinued Product

Unfortunately Trimethoprim (Cat. No. 0650) has been withdrawn from sale for commercial reasons.
Cat.No. 0650 - Trimethoprim | C14H18N4O3 | CAS No. 738-70-5
Description: Dihydrofolate reductase inhibitor
Purity: ≥98% (HPLC)

Biological Activity

Antibacterial. Potently inhibits bacterial and protozoal dihydrofolate reductase.

Technical Data

M. Wt 290.32
Formula C14H18N4O3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 738-70-5
Smiles NC2=NC=C(C(N)=N2)CC1=CC(OC)=C(OC)C(OC)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 290.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.44 mL 17.22 mL 34.44 mL
5 mM 0.69 mL 3.44 mL 6.89 mL
10 mM 0.34 mL 1.72 mL 3.44 mL
50 mM 0.07 mL 0.34 mL 0.69 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service
Safety Datasheet


References are publications that support the products' biological activity.

Brogden et al (1982) Trimethoprim: a review of its antibacterial activity, pharmacokinetics and therapeutic use in urinary tract infections. Drugs 23 405 PMID: 7049657

Merck Index 12 9840 PMID:

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Keywords: Trimethoprim, supplier, Dihydrofolate, reductase, inhibitors, inhibits, DHFR, Reductase, Reductases, antibacterial, Dihydrofolate, Reductase, Dihydrofolate, Reductase, Tocris Bioscience

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