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Submit Reviewtrans-Triprolidine hydrochloride
Description: Highly potent H1 antagonist
Chemical Name: (E)-2-[1-(4-Methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]pyridine hydrochloride
Purity: ≥99% (HPLC)
Biological Activity
Potent H1 receptor antagonist.
Technical Data
| M. Wt | 314.86 |
| Formula | C19H22N2.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 550-70-9 |
| PubChem ID | 5702129 |
| InChI Key | WYUYEJNGHIOFOC-NWBUNABESA-N |
| Smiles | Cl[H].CC1=CC=C(C=C1)C(=C/CN1CCCC1)\C1=CC=CC=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 31.49 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 314.86. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.18 mL | 15.88 mL | 31.76 mL |
| 5 mM | 0.64 mL | 3.18 mL | 6.35 mL |
| 10 mM | 0.32 mL | 1.59 mL | 3.18 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
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References
References are publications that support the biological activity of the product.
Hill (1990) Distribution properties and functional characteristics of three classes of histamine receptor. Pharmacol.Rev. 42 45 PMID: 2164693
Merck Index 12 9877
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Keywords: trans-Triprolidine hydrochloride, trans-Triprolidine hydrochloride supplier, H1, antagonists, potent, Receptors, Histamine, histaminergic, 0662, Tocris Bioscience
2 Citations for trans-Triprolidine hydrochloride
Citations are publications that use Tocris products. Selected citations for trans-Triprolidine hydrochloride include:
Kwiatkowski et al (2013) Coordination of distinct but interacting rhythmic motor programs by a modulatory projection neuron using different co-transmitters in different ganglia. J Exp Biol 216 1827 PMID: 23393282
Femenia et al (2015) Hippocampal-Dependent Antidepressant Action of the H3 Receptor Antagonist Clobenpropit in a Rat Model of Depression. Int J Neuropsychopharmacol 18 PMID: 25762718
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