trans-4-Hydroxycrotonic acid

Discontinued Product

trans-4-Hydroxycrotonic acid (Cat. No. 0538) has been withdrawn from sale for commercial reasons.
Cat.No. 0538 - trans-4-Hydroxycrotonic acid | C4H6O3 | CAS No. 24587-49-3
Description: GHB receptor ligand
Chemical Name: trans-4-Hydroxy-2-butenoic acid
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Binds to the γ-hydroxybutyric acid (GHB) receptor with higher affinity than GHB itself. May be an endogenous ligand.

Technical Data

M. Wt 102.09
Formula C4H6O3
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 24587-49-3
PubChem ID 6155526
InChI Key RMQJECWPWQIIPW-OWOJBTEDSA-N
Smiles OC\C=C\C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Bourguignon et al (1988) Analogues of γ-hydroxybutyric acid. Synthesis and binding studies. J.Med.Chem. 31 893 PMID: 3361576

Hechler et al (1993) Gamma hydroxybutyrate ligands posses antiDArgic and neuroleptic-like activities. J.Pharmacol.Exp.Ther. 264 1406 PMID: 8095552

Vayer et al (1985) Natural occurrence of trans-gamma hydroxycrotonic acid in rat brain. Biochem.Pharmacol. 34 2401 PMID: 4015683

Keywords: trans-4-Hydroxycrotonic acid, trans-4-Hydroxycrotonic acid supplier, GHB, receptor, ligand, GABAB, Receptors, GABAA, GABAC, Miscellaneous, GABA, 0538, Tocris Bioscience

Citations for trans-4-Hydroxycrotonic acid

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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GABA Receptors

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.