trans-4-Hydroxycrotonic acid

Pricing Availability Delivery Time Qty
Cat.No. 0538 - trans-4-Hydroxycrotonic acid | C4H6O3 | CAS No. 24587-49-3
Description: GHB receptor ligand
Chemical Name: trans-4-Hydroxy-2-butenoic acid
Purity: ≥99% (HPLC)

Biological Activity

Binds to the γ-hydroxybutyric acid (GHB) receptor with higher affinity than GHB itself.  May be an endogenous ligand.

Technical Data

M. Wt 102.09
Formula C4H6O3
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 24587-49-3
PubChem ID 6155526
Smiles OC\C=C\C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 10.21 100

Preparing Stock Solutions

The following data is based on the product molecular weight 102.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 9.8 mL 48.98 mL 97.95 mL
5 mM 1.96 mL 9.8 mL 19.59 mL
10 mM 0.98 mL 4.9 mL 9.8 mL
50 mM 0.2 mL 0.98 mL 1.96 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Bourguignon et al (1988) Analogues of γ-hydroxybutyric acid. Synthesis and binding studies. J.Med.Chem. 31 893 PMID: 3361576

Hechler et al (1993) Gamma hydroxybutyrate ligands posses antidopaminergic and neuroleptic-like activities. J.Pharmacol.Exp.Ther. 264 1406 PMID: 8095552

Vayer et al (1985) Natural occurrence of trans-gamma hydroxycrotonic acid in rat brain. Biochem.Pharmacol. 34 2401 PMID: 4015683

If you know of a relevant reference for trans-4-Hydroxycrotonic acid, please let us know.

Keywords: trans-4-Hydroxycrotonic acid, supplier, GHB, receptor, ligand, GABAB, Receptors, GABAA, GABAC, Miscellaneous, GABA, GABAB, Receptors, Miscellaneous, GABA, Tocris Bioscience

Citations for trans-4-Hydroxycrotonic acid

Citations are publications that use Tocris products.

Currently there are no citations for trans-4-Hydroxycrotonic acid. Do you know of a great paper that uses trans-4-Hydroxycrotonic acid from Tocris? If so please let us know.

trans-4-Hydroxycrotonic acid Reviews

Average Rating:

(Based on 0 Reviews)

1 Star
2 Star
3 Star
4 Star
5 Star

Have you used trans-4-Hydroxycrotonic acid?

Submit a review and receive a $25US/€18/£15/$25CAN Amazon gift card if you include an image -$10US/€7/£6/$10CAN Amazon gift card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Literature in this Area

GABA Receptors

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.