Binds to the γ-hydroxybutyric acid (GHB) receptor with higher affinity than GHB itself. May be an endogenous ligand.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 102.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||9.8 mL||48.98 mL||97.95 mL|
|5 mM||1.96 mL||9.8 mL||19.59 mL|
|10 mM||0.98 mL||4.9 mL||9.8 mL|
|50 mM||0.2 mL||0.98 mL||1.96 mL|
References are publications that support the products' biological activity.
Bourguignon et al (1988) Analogues of γ-hydroxybutyric acid. Synthesis and binding studies. J.Med.Chem. 31 893 PMID: 3361576
Hechler et al (1993) Gamma hydroxybutyrate ligands posses antidopaminergic and neuroleptic-like activities. J.Pharmacol.Exp.Ther. 264 1406 PMID: 8095552
Vayer et al (1985) Natural occurrence of trans-gamma hydroxycrotonic acid in rat brain. Biochem.Pharmacol. 34 2401 PMID: 4015683
If you know of a relevant reference for trans-4-Hydroxycrotonic acid, please let us know.
Keywords: trans-4-Hydroxycrotonic acid, supplier, GHB, receptor, ligand, GABAB, Receptors, GABAA, GABAC, Miscellaneous, GABA, GABAB, Receptors, Miscellaneous, GABA, Tocris Bioscience
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GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.