TRAM 39

Pricing Availability Delivery Time Qty
Cat.No. 4952 - TRAM 39 | C20H14ClN | CAS No. 197525-99-8
Description: Potent KCa3.1 blocker
Chemical Name: 2-Chloro-α,α-diphenylbenzeneacetonitrile
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent intermediate conductance Ca2+-activated K+ channel (KCa3.1) blocker (Kd = 60 nM). Has no effect on cytochrome p450 activity. Inhibits I-EBIO-stimulated increases in rat artery membrane potential ex vivo. Also diminishes LPS-induced cryptidin (mammalian α-defensin) release from paneth cells in vitro.

Compound Libraries

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Technical Data

M. Wt 303.78
Formula C20H14ClN
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 197525-99-8
PubChem ID 9861261
InChI Key JHNRTPKGSCVKKC-UHFFFAOYSA-N
Smiles ClC(C=CC=C3)=C3C(C2=CC=CC=C2)(C#N)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 15.44 50
ethanol 3.09 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 303.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.29 mL 16.46 mL 32.92 mL
5 mM 0.66 mL 3.29 mL 6.58 mL
10 mM 0.33 mL 1.65 mL 3.29 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Wulff et al (2000) Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant. Proc.Natl.Acad.Sci.U.S.A. 97 8151 PMID: 10884437

Burnham et al (2006) Impaired small-conductance Ca2+-activated K+ channel-dependent EDHF responses in Type II diabetic ZDF rats. Br.J.Pharmacol. 148 434 PMID: 16682967

Ayabe et al (2002) Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel. J.Biol.Chem. 277 3793 PMID: 11724775


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View all Calcium-Activated Potassium (KCa) Channel Blockers

Keywords: TRAM39 potent intermediate conductance calcium Ca2+ actiavted potassium K+ channels blockers blocks KCa3.1 IKCa1 ion channels Ca2+-Activated Potassium Channels

Citations for TRAM 39

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