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Submit ReviewTRAM 39
Description: Potent KCa3.1 (IK) blocker
Chemical Name: 2-Chloro-α,α-diphenylbenzeneacetonitrile
Purity: ≥99% (HPLC)
Biological Activity for TRAM 39
TRAM 39 is a potent intermediate conductance Ca2+-activated K+ channel (KCa3.1) blocker (Kd = 60 nM). Has no effect on cytochrome p450 activity. Inhibits I-EBIO-stimulated increases in rat artery membrane potential ex vivo. Also diminishes LPS-induced cryptidin (mammalian α-defensin) release from paneth cells in vitro.
Technical Data for TRAM 39
| M. Wt | 303.78 |
| Formula | C20H14ClN |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 197525-99-8 |
| PubChem ID | 9861261 |
| InChI Key | JHNRTPKGSCVKKC-UHFFFAOYSA-N |
| Smiles | ClC(C=CC=C3)=C3C(C2=CC=CC=C2)(C#N)C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TRAM 39
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 15.44 | 50 |
Preparing Stock Solutions for TRAM 39
The following data is based on the product molecular weight 303.78. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 6.58 mL | 32.92 mL | 65.84 mL |
| 2.5 mM | 1.32 mL | 6.58 mL | 13.17 mL |
| 5 mM | 0.66 mL | 3.29 mL | 6.58 mL |
| 25 mM | 0.13 mL | 0.66 mL | 1.32 mL |
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Product Datasheets for TRAM 39
References for TRAM 39
References are publications that support the biological activity of the product.
Wulff et al (2000) Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant. Proc.Natl.Acad.Sci.U.S.A. 97 8151 PMID: 10884437
Burnham et al (2006) Impaired small-conductance Ca2+-activated K+ channel-dependent EDHF responses in Type II diabetic ZDF rats. Br.J.Pharmacol. 148 434 PMID: 16682967
Ayabe et al (2002) Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel. J.Biol.Chem. 277 3793 PMID: 11724775
If you know of a relevant reference for TRAM 39, please let us know.
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Keywords: TRAM 39, TRAM 39 supplier, TRAM39, potent, intermediate, conductance, calcium, Ca2+, actiavted, potassium, K+, channels, blockers, blocks, KCa3.1, IKCa1, ion, Ca2+-Activated, Potassium, Channels, 4952, Tocris Bioscience
Citations for TRAM 39
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Reviews for TRAM 39
Average Rating: 5 (Based on 1 Review.)
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Selective blocker worked ideally to block Calcium activated K+ channels.
By
Anonymous on 10/22/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: HEK 293
Product was used on BK channel.Calcium activated potassium channels were expressed by HEK 293 cells which was used for the study.It shows moderate blocking activity and the data patterns were similar throughout the study.
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