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Description: Potent KCa3.1 (IK) blocker
Chemical Name: 2-Chloro-α,α-diphenylbenzeneacetonitrile
Purity: ≥99% (HPLC)
Reviews (1)

Biological Activity for TRAM 39

TRAM 39 is a potent intermediate conductance Ca2+-activated K+ channel (KCa3.1) blocker (Kd = 60 nM). Has no effect on cytochrome p450 activity. Inhibits I-EBIO-stimulated increases in rat artery membrane potential ex vivo. Also diminishes LPS-induced cryptidin (mammalian α-defensin) release from paneth cells in vitro.

Technical Data for TRAM 39

M. Wt 303.78
Formula C20H14ClN
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 197525-99-8
PubChem ID 9861261
Smiles ClC(C=CC=C3)=C3C(C2=CC=CC=C2)(C#N)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TRAM 39

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 15.44 50

Preparing Stock Solutions for TRAM 39

The following data is based on the product molecular weight 303.78. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 6.58 mL 32.92 mL 65.84 mL
2.5 mM 1.32 mL 6.58 mL 13.17 mL
5 mM 0.66 mL 3.29 mL 6.58 mL
25 mM 0.13 mL 0.66 mL 1.32 mL

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References for TRAM 39

References are publications that support the biological activity of the product.

Wulff et al (2000) Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant. Proc.Natl.Acad.Sci.U.S.A. 97 8151 PMID: 10884437

Burnham et al (2006) Impaired small-conductance Ca2+-activated K+ channel-dependent EDHF responses in Type II diabetic ZDF rats. Br.J.Pharmacol. 148 434 PMID: 16682967

Ayabe et al (2002) Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel. J.Biol.Chem. 277 3793 PMID: 11724775

If you know of a relevant reference for TRAM 39, please let us know.

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Citations for TRAM 39

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Reviews for TRAM 39

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Selective blocker worked ideally to block Calcium activated K+ channels.
By Anonymous on 10/22/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: HEK 293

Product was used on BK channel.Calcium activated potassium channels were expressed by HEK 293 cells which was used for the study.It shows moderate blocking activity and the data patterns were similar throughout the study.

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