TRAM 39

Pricing Availability   Qty
Description: Potent KCa3.1 (IK) blocker
Chemical Name: 2-Chloro-α,α-diphenylbenzeneacetonitrile
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews (1)
Literature (2)

Biological Activity for TRAM 39

TRAM 39 is a potent intermediate conductance Ca2+-activated K+ channel (KCa3.1) blocker (Kd = 60 nM). Has no effect on cytochrome p450 activity. Inhibits I-EBIO-stimulated increases in rat artery membrane potential ex vivo. Also diminishes LPS-induced cryptidin (mammalian α-defensin) release from paneth cells in vitro.

Technical Data for TRAM 39

M. Wt 303.78
Formula C20H14ClN
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 197525-99-8
PubChem ID 9861261
InChI Key JHNRTPKGSCVKKC-UHFFFAOYSA-N
Smiles ClC(C=CC=C3)=C3C(C2=CC=CC=C2)(C#N)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TRAM 39

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 15.44 50

Preparing Stock Solutions for TRAM 39

The following data is based on the product molecular weight 303.78. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 6.58 mL 32.92 mL 65.84 mL
2.5 mM 1.32 mL 6.58 mL 13.17 mL
5 mM 0.66 mL 3.29 mL 6.58 mL
25 mM 0.13 mL 0.66 mL 1.32 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for TRAM 39

References are publications that support the biological activity of the product.

Wulff et al (2000) Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant. Proc.Natl.Acad.Sci.U.S.A. 97 8151 PMID: 10884437

Burnham et al (2006) Impaired small-conductance Ca2+-activated K+ channel-dependent EDHF responses in Type II diabetic ZDF rats. Br.J.Pharmacol. 148 434 PMID: 16682967

Ayabe et al (2002) Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel. J.Biol.Chem. 277 3793 PMID: 11724775


If you know of a relevant reference for TRAM 39, please let us know.

View Related Products by Product Action

View all Calcium-Activated Potassium (KCa) Channel Blockers

Keywords: TRAM 39, TRAM 39 supplier, TRAM39, potent, intermediate, conductance, calcium, Ca2+, actiavted, potassium, K+, channels, blockers, blocks, KCa3.1, IKCa1, ion, Ca2+-Activated, Potassium, Channels, 4952, Tocris Bioscience

Citations for TRAM 39

Citations are publications that use Tocris products.

Currently there are no citations for TRAM 39. Do you know of a great paper that uses TRAM 39 from Tocris? Please let us know.

Reviews for TRAM 39

Average Rating: 5 (Based on 1 Review.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used TRAM 39?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


Selective blocker worked ideally to block Calcium activated K+ channels.
By Anonymous on 10/22/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: HEK 293

Product was used on BK channel.Calcium activated potassium channels were expressed by HEK 293 cells which was used for the study.It shows moderate blocking activity and the data patterns were similar throughout the study.

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Ion Channel Product Listing

Ion Channel Product Listing

A collection of around 500 products for ion channel research, the listing includes research tools for the study of:

  • Ligand-gated ion channels
  • Voltage-gated ion channels
  • Other Ion Channels
Epilepsy Poster

Epilepsy Poster

Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.