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Tocriscreen Kinase Inhibitor Toolbox
A collection of 157 kinase inhibitors supplied pre-dissolved in DMSO (250 μL 10 mM solution). Comprises a subset of the Tocriscreen Plus (Cat. No. 5840) compound library. The Kinase Inhibitor Toolbox contains compounds targeting >60 different kinases, including extensive coverage of well-established targets such as VEFGR, AKT and TGFβR as well as more novel targets such as LIMK, Hapsin, NUAK1 and DYRK.
Key Format and Product Details
- 96-well racks with Matrix storage tubes & SepraSeal caps
- Pre-dissolved in DMSO
- Compounds arranged 80 per rack with two racks per library
- Many compounds are exclusive to Tocris
- Full chemical and biological data available
- Exceptional purity
Request Compound List
To request a list of the compounds available in the Tocriscreen Kinase Inhibitor Toolbox please click the request tile below. Compound lists can be provided in Excel or SD format.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
If you know of a relevant reference for Tocriscreen Kinase Inhibitor Toolbox, please let us know.
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3 Citations for Tocriscreen Kinase Inhibitor Toolbox
Citations are publications that use Tocris products. Selected citations for Tocriscreen Kinase Inhibitor Toolbox include:
Sandilands et al (2015) p70S6K is regulated by focal adhesion kinase and is required for Src-selective autophagy. Cell Signal. 27 1816 PMID: 26071201
Tandon et al (2015) SD-208, a novel protein kinase D inhibitor, blocks prostate cancer cell proliferation and tumor growth in vivo by inducing G2/M cell cycle arrest. PLoS One 10 e0119346 PMID: 25747583
Markussen et al (2018) GSK3 is a negative regulator of the thermogenic program in brown adipocytes. Sci.Rep. 8 3469 PMID: 29472592
Do you know of a great paper that uses Tocriscreen Kinase Inhibitor Toolbox from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Compound Libraries & Toolboxes
This brochure gives an overview of the unique TocriscreenTM compound libraries and toolboxes available from Tocris, including the Tocriscreen Plus, and toolboxes for the study of epigenetics, kinases and stem cells.
- Tocriscreen Plus & Plus Mini
- Custom Libraries
- FDA-Approved Compounds
- Tocriscreen Toolboxes
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Epigenetics in Cancer Poster
Adapted from the 2015 Cancer Product Guide Edition 3, this poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.