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Tocriscreen Kinase Inhibitor Library
Biological Activity for Tocriscreen Kinase Inhibitor Library
Tocriscreen Kinase Inhibitor Library is a collection of 160 kinase inhibitors supplied pre-dissolved in DMSO (250 μL 10 mM solution). The Tocriscreen Kinase Inhibitor Library contains compounds targeting >60 different kinases, including extensive coverage of well-established targets such as VEFGR, AKT and TGFβR as well as more novel targets such as LIMK, Hapsin, NUAK1 and DYRK.
If this library does not suit your needs, please submit your requirements through our Tocriscreen PRO custom compound library service.
Key Format and Product Details for Tocriscreen Kinase Inhibitor Library
- 96-well racks with Matrix storage tubes & SepraSeal caps
- Pre-dissolved in DMSO
- Compounds arranged 80 per rack with two racks per library
- Many compounds are exclusive to Tocris
- Full chemical and biological data available
- Exceptional purity
The Tocriscreen Kinase Inhibitors Library contains bioactive compounds covering a diverse range of kinases, including established enzymes and more novel targets.
Technical Data for Tocriscreen Kinase Inhibitor Library
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Tocriscreen Kinase Inhibitor Library
References for Tocriscreen Kinase Inhibitor Library
References are publications that support the biological activity of the product.
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19 Citations for Tocriscreen Kinase Inhibitor Library
Citations are publications that use Tocris products. Selected citations for Tocriscreen Kinase Inhibitor Library include:
FitzGerald et al (2014) A high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage response. PLoS One 9 e98891 PMID: 24902048
Acevedo et al (2014) Phosphorylation of amyloid precursor protein at threonine 668 is essential for its copper-responsive trafficking in SH-SY5Y neuroblastoma cells. J Biol Chem 289 11007 PMID: 24610780
Gull et al (2022) Screening of chemical libraries using xenopus embryos and tadpoles for phenotypic drug discovery. Cold Spring Harb.Protoc. PMID: 36180216
Carlson et al (2022) Discovery and characterization of multiple classes of human CatSper blockers. Chem Med Chem 17 e202000499 PMID: 35644882
Azad et al (2018) A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis. Nat Commun 9 1061 PMID: 29535383
Moeschler et al (2018) 1-Benzyl-3-cetyl-2-methylimidazolium Iodide (NH125) Is a Broad-Spectrum Inhibitor of Virus Entry with Lysosomotropic Features. Viruses 10 E306 PMID: 29874821
Tomilov et al (2018) Idebenone is a cytoprotective insulin sensitizer whose mechanism is Shc inhibition. Pharmacol Res 137 89 PMID: 30290222
Sandilands et al (2015) p70S6K is regulated by focal adhesion kinase and is required for Src-selective autophagy. Cell Signal. 27 1816 PMID: 26071201
Tandon et al (2015) SD-208, a novel protein kinase D inhibitor, blocks prostate cancer cell proliferation and tumor growth in vivo by inducing G2/M cell cycle arrest. PLoS One 10 e0119346 PMID: 25747583
Markussen et al (2018) GSK3 is a negative regulator of the thermogenic program in brown adipocytes. Sci.Rep. 8 3469 PMID: 29472592
Moujalled et al (2013) Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress. PLoS One 8 e67433 PMID: 23840699
Jacoby et al (2017) Protocols for the design of kinase-focused compound libraries. Mol Inform 37 e1700119 PMID: 29116686
Lee et al (2021) A screen of kinase inhibitors reveals a potential role of Chk1 in regulating Hydra head regeneration and maintenance. Int J Dev Biol 65 523 PMID: 3454979
Sherman and Rossi (2019) A Novel Three-Dimensional Glioma Blood-Brain Barrier Model for High-Throughput Testing of Tumoricidal Capability. Front Oncol 9 351 PMID: 31131260
Hewage et al (2020) Chemical manipulation of abscisic acid signaling: a new approach to abiotic and biotic stress management in agriculture. Adv.Sci. 7 2001265 PMID: 32999840
Wang et al (2019) EGFR-Aurka signaling rescues polarity and regeneration defects in dystrophin-deficient muscle stem cells by increasing asymmetric divisions. Cell Stem Cell 24 419 PMID: 30713094
Moret et al (2019) Cheminformatics tools for analyzing and designing optimized small-molecule collections and libraries. Cell Chem Biol 26 765 PMID: 30956147
Chaudhari et al (2019) Transient c-Src Suppression During Endodermal Commitment of Human Induced Pluripotent Stem Cells Results in Abnormal Profibrotic Cholangiocyte-Like Cells. Stem Cells 37 306 PMID: 30471152
Yang et al (2019) NTRK1 is a positive regulator of YAP oncogenic function. Oncogene 38 2778 PMID: 30542115
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.