Tocriscreen Kinase Inhibitor Toolbox

Description: 80 Kinase inhibitors supplied pre-dissolved in DMSO (250 μL 10 mM solutions)
Datasheet
Citations (3)
Literature

Biological Activity

A collection of 80 kinase inhibitors supplied as pre-dissolved DMSO solutions (250 μl 10 mM solution per compound).

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To request a list of the compounds available in the Tocriscreen Kinase Inhibitor Toolbox please click the request tile below. Compound lists can be provided in Excel or SD format.

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Technical Data

Storage Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Product Datasheets

Certificate of Analysis is currently unavailable
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Safety Datasheet

References

References are publications that support the products' biological activity.

Jester et al (2010) A coiled-coil enabled split-luciferase three-hybrid system: applied toward profiling inhibitors of protein kinases. J.Am.Chem.Soc. 132 11727 PMID: 20669947

Moujalled et al (2013) Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress. PLoS ONE 8 e67433 PMID: 23840699

Keywords: 80 kinase inhibitors inhibits supplied pre-dissolved DMSO 250mul 10mM solutions Tocriscreen Compound Library Collections Kinases Screening Library Libraries HTS HCS high throughput content Tocriscreen Toolboxes

3 Citations for Tocriscreen Kinase Inhibitor Toolbox

Citations are publications that use Tocris products. Selected citations for Tocriscreen Kinase Inhibitor Toolbox include:

FitzGerald et al (2014) A high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage response. PLoS One 9 e98891 PMID: 24902048

Acevedo et al (2014) Phosphorylation of amyloid precursor protein at threonine 668 is essential for its copper-responsive trafficking in SH-SY5Y neuroblastoma cells. Cancer Sci 289 11007 PMID: 24610780

Moujalled et al (2013) Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress. PLoS One 8 e67433 PMID: 23840699


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Reviews

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Literature in this Area

Epigenetics

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

MAPK Signaling

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Stem Cells

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Pathways for Tocriscreen Kinase Inhibitor Toolbox

Protocols

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