High affinity, selective P2X receptor antagonist. Inhibits ATP-induced currents in cells expressing P2X1, P2X3 and P2X2/3 receptors with IC50 values of 6, 0.9, and 7 nM respectively. Displays 1000-fold selectivity over P2X2, P2X4 and P2X7.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
References are publications that support the biological activity of the product.
Lewis et al (1998) 2',3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP) - a nanomolar affinity antagonist at rat mesenteric artery P2X receptor ion channels. Br.J.Pharmacol. 124 1463 PMID: 9723959
Thomas et al (1998) The antagonist trinitrophenyl-ATP reveals co-existence of distinct P2X receptor channels in rat nodose channels. J.Physiol. 509 411 PMID: 9575290
Virginio et al (1998) Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3 and heteromeric P2X2/3 receptors. Mol.Pharmacol. 53 969 PMID: 9614197
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Keywords: TNP-ATP, TNP-ATP supplier, High, affinity, selective, P2X, receptor, antagonist., Inhibits, ATP-induced, currents, in, cells, expressing, P2X1, P2X3, and, P2X2/3, receptors, with, IC50, values, of, 6, 0.9, 7, nM, respectively., Displays, 1000-fold, selectivity, over, P2X2, P2X4, P2X7., Receptors, 1294, Tocris Bioscience
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.