You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for TNP-ATP
High affinity, selective P2X receptor antagonist. Inhibits ATP-induced currents in cells expressing P2X1, P2X3 and P2X2/3 receptors with IC50 values of 6, 0.9, and 7 nM respectively. Displays 1000-fold selectivity over P2X2, P2X4 and P2X7.
Technical Data for TNP-ATP
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TNP-ATP
References for TNP-ATP
References are publications that support the biological activity of the product.
Lewis et al (1998) 2',3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP) - a nanomolar affinity antagonist at rat mesenteric artery P2X receptor ion channels. Br.J.Pharmacol. 124 1463 PMID: 9723959
Thomas et al (1998) The antagonist trinitrophenyl-ATP reveals co-existence of distinct P2X receptor channels in rat nodose channels. J.Physiol. 509 411 PMID: 9575290
Virginio et al (1998) Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3 and heteromeric P2X2/3 receptors. Mol.Pharmacol. 53 969 PMID: 9614197
View Related Products by Target
View Related Products by Product Action
Keywords: TNP-ATP, TNP-ATP supplier, High, affinity, selective, P2X, receptor, antagonist., Inhibits, ATP-induced, currents, in, cells, expressing, P2X1, P2X3, and, P2X2/3, receptors, with, IC50, values, of, 6, 0.9, 7, nM, respectively., Displays, 1000-fold, selectivity, over, P2X2, P2X4, P2X7., Receptors, 1294, Tocris Bioscience
Citations for TNP-ATP
Citations are publications that use Tocris products.
Currently there are no citations for TNP-ATP.
Reviews for TNP-ATP
There are currently no reviews for this product. Be the first to review TNP-ATP and earn rewards!
Have you used TNP-ATP?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.