TNP-ATP

Discontinued Product

TNP-ATP (Cat. No. 1294) has been withdrawn from sale for commercial reasons.
Cat.No. 1294 - TNP-ATP | C16H12N8O19P3 Li3Na2 | CAS No. 61368-63-6
Description: Potent, selective P2X antagonist
Chemical Name: 2¢,3¢-O-(2,4,6-Trinitrophenyl)adenosine-5¢-triphosphate
Datasheet
Citations
Reviews
Literature

Biological Activity

High affinity, selective P2X receptor antagonist. Inhibits ATP-induced currents in cells expressing P2X1, P2X3 and P2X2/3 receptors with IC50 values of 6, 0.9, and 7 nM respectively. Displays 1000-fold selectivity over P2X2, P2X4 and P2X7.

Technical Data

M. Wt 780.04
Formula C16H12N8O19P3 Li3Na2
Storage Desiccate at -20°C
CAS Number 61368-63-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Product Datasheets

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Safety Datasheet

References

References are publications that support the biological activity of the product.

Lewis et al (1998) 2',3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP) - a nanomolar affinity antagonist at rat mesenteric artery P2X receptor ion channels. Br.J.Pharmacol. 124 1463 PMID: 9723959

Thomas et al (1998) The antagonist trinitrophenyl-ATP reveals co-existence of distinct P2X receptor channels in rat nodose channels. J.Physiol. 509 411 PMID: 9575290

Virginio et al (1998) Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3 and heteromeric P2X2/3 receptors. Mol.Pharmacol. 53 969 PMID: 9614197

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Keywords: TNP-ATP, TNP-ATP supplier, High, affinity, selective, P2X, receptor, antagonist., Inhibits, ATP-induced, currents, in, cells, expressing, P2X1, P2X3, and, P2X2/3, receptors, with, IC50, values, of, 6, 0.9, 7, nM, respectively., Displays, 1000-fold, selectivity, over, P2X2, P2X4, P2X7., Receptors, 1294, Tocris Bioscience

Citations for TNP-ATP

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