TNP-ATP triethylammonium salt
High affinity, selective P2X receptor antagonist. Inhibits ATP-induced currents in cells expressing P2X1, P2X3 and heteromeric P2X2/3 receptors with IC50 values of 6, 0.9 and 7 nM respectively. Displays 1000-fold selectivity over P2X2, P2X4 and P2X7.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble in water (supplied pre-dissolved at a concentration of 10mM)|
Preparing Stock Solutions
The following data is based on the product molecular weight 1123.04. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.89 mL||4.45 mL||8.9 mL|
|5 mM||0.18 mL||0.89 mL||1.78 mL|
|10 mM||0.09 mL||0.45 mL||0.89 mL|
|50 mM||0.02 mL||0.09 mL||0.18 mL|
References are publications that support the products' biological activity.
Virginio et al (1998) Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3 and heteromeric P2X2/3 receptors. Mol.Pharmacol. 53 969 PMID: 9614197
Lewis et al (1998) 2',3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP) - a nanomolar affinity antagonist at rat mesenteric artery P2X receptor ion channels. Br.J.Pharmacol. 124 1463 PMID: 9723959
Thomas et al (1998) The antagonist trinitrophenyl-ATP reveals co-existence of distinct P2X receptor channels in rat nodose channels. J.Physiol. 509.2 411 PMID: 9575290
Burgard et al (2000) Competitive antagonism of recombinant P2X(2/3) receptors by 2', 3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP). Mol.Pharmacol. 58 1502 PMID: 11093790
Spelta et al (2002) Kinetics of antagonist actions at rat P2X2/3 heteromeric receptors. Br.J.Pharmacol. 135 1524 PMID: 11906966
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Keywords: TNP-ATP triethylammonium salt, supplier, Potent, selective, P2X, antagonists, Receptors, Purinergic, purinoceptors, P2X, Receptors, P2X, Receptors, Tocris Bioscience
3 Citations for TNP-ATP triethylammonium salt
Citations are publications that use Tocris products. Selected citations for TNP-ATP triethylammonium salt include:
Ghalali et al (2014) Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and PH domain and leucine-rich repeat phosphatase cross-talk (PHLPP) in cancer cells and in transforming growth factor β-activated stem cells. J Biol Chem 289 11601 PMID: 24599953
Shabir et al (2013) Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium. Naunyn Schmiedebergs Arch Pharmacol 305 F396 PMID: 23720349
Manohar et al (2012) ATP release and autocrine signaling through P2X4 receptors regulate γδ T cell activation. J Leukoc Biol 92 787 PMID: 22753954
Do you know of a great paper that uses TNP-ATP triethylammonium salt from Tocris? If so please let us know.
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