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TNP-ATP triethylammonium salt is a high affinity, selective P2X receptor antagonist. Inhibits ATP-induced currents in cells expressing P2X1, P2X3 and heteromeric P2X2/3 receptors with IC50 values of 6, 0.9 and 7 nM respectively. Displays 1000-fold selectivity over P2X2, P2X4 and P2X7.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble in water (supplied pre-dissolved at a concentration of 10mM)|
References are publications that support the biological activity of the product.
Virginio et al (1998) Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3 and heteromeric P2X2/3 receptors. Mol.Pharmacol. 53 969 PMID: 9614197
Lewis et al (1998) 2',3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP) - a nanomolar affinity antagonist at rat mesenteric artery P2X receptor ion channels. Br.J.Pharmacol. 124 1463 PMID: 9723959
Thomas et al (1998) The antagonist trinitrophenyl-ATP reveals co-existence of distinct P2X receptor channels in rat nodose channels. J.Physiol. 509.2 411 PMID: 9575290
Burgard et al (2000) Competitive antagonism of recombinant P2X(2/3) receptors by 2', 3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP). Mol.Pharmacol. 58 1502 PMID: 11093790
Spelta et al (2002) Kinetics of antagonist actions at rat P2X2/3 heteromeric receptors. Br.J.Pharmacol. 135 1524 PMID: 11906966
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Keywords: TNP-ATP triethylammonium salt, TNP-ATP triethylammonium salt supplier, Potent, selective, P2X, antagonists, Receptors, Purinergic, purinoceptors, 61368-63-6, 120360-48-7, 2464, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for TNP-ATP triethylammonium salt include:
McEwan et al (2021) Autocrine regulation of wound healing by ATP release and P2Y2 receptor activation Life Sci 283 119850 PMID: 34314735
Ghalali et al (2014) Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and PH domain and leucine-rich repeat phosphatase cross-talk (PHLPP) in cancer cells and in transforming growth factor β-activated stem cells. J Biol Chem 289 11601 PMID: 24599953
Manohar et al (2012) ATP release and autocrine signaling through P2X4 receptors regulate γδ T cell activation. J Leukoc Biol 92 787 PMID: 22753954
Mohammed et al (2017) Veratridine produces distinct calcium response profiles in mouse Dorsal Root Ganglia neurons. Sci Rep 7 45221 PMID: 28338073
Shabir et al (2013) Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium. Naunyn Schmiedebergs Arch Pharmacol 305 F396 PMID: 23720349
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.