TNP-ATP triethylammonium salt

Pricing Availability Delivery Time Qty
Cat.No. 2464 - TNP-ATP triethylammonium salt | C16H13N8O19P3.C24H64N4 | CAS No. 61368-63-6
Description: Potent, selective P2X antagonist
Chemical Name: 2',3'-O-(2,4,6-Trinitrophenyl)adenosine-5'-triphosphate tetra(triethylammonium) salt
Purity: ≥95% (HPLC)
Datasheet
Citations (3)
Literature

Biological Activity

High affinity, selective P2X receptor antagonist. Inhibits ATP-induced currents in cells expressing P2X1, P2X3 and heteromeric P2X2/3 receptors with IC50 values of 6, 0.9 and 7 nM respectively. Displays 1000-fold selectivity over P2X2, P2X4 and P2X7.

Technical Data

M. Wt 1123.04
Formula C16H13N8O19P3.C24H64N4
Storage Desiccate at -20°C
Purity ≥95% (HPLC)
CAS Number 61368-63-6
PubChem ID 75358143
InChI Key XTSNRUFLZVGKOU-NRBYJGOSSA-O
Smiles NC1=C2C(N([C@@H]3O[C@H](COP(OP(OP([O-])(O)=O)([O-])=O)([O-])=O)[C@]4([H])[C@]([H])3OC(C([N+]([O-])=O)=C/C(C=C5[N+]([O-])=O)=[N+]([O-])/[O-])5O4)C=N2)=NC=N1.CC[N+](CC)([H])CC.CC[N+](CC)([H])CC.CC[N+](CC)([H])CC.CC[N+](CC)([H])CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble in water (supplied pre-dissolved at a concentration of 10mM)

Preparing Stock Solutions

The following data is based on the product molecular weight 1123.04. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.89 mL 4.45 mL 8.9 mL
5 mM 0.18 mL 0.89 mL 1.78 mL
10 mM 0.09 mL 0.45 mL 0.89 mL
50 mM 0.02 mL 0.09 mL 0.18 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Virginio et al (1998) Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3 and heteromeric P2X2/3 receptors. Mol.Pharmacol. 53 969 PMID: 9614197

Lewis et al (1998) 2',3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP) - a nanomolar affinity antagonist at rat mesenteric artery P2X receptor ion channels. Br.J.Pharmacol. 124 1463 PMID: 9723959

Thomas et al (1998) The antagonist trinitrophenyl-ATP reveals co-existence of distinct P2X receptor channels in rat nodose channels. J.Physiol. 509.2 411 PMID: 9575290

Burgard et al (2000) Competitive antagonism of recombinant P2X(2/3) receptors by 2', 3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP). Mol.Pharmacol. 58 1502 PMID: 11093790

Spelta et al (2002) Kinetics of antagonist actions at rat P2X2/3 heteromeric receptors. Br.J.Pharmacol. 135 1524 PMID: 1906966


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3 Citations for TNP-ATP triethylammonium salt

Citations are publications that use Tocris products. Selected citations for TNP-ATP triethylammonium salt include:

Ghalali et al (2014) Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and PH domain and leucine-rich repeat phosphatase cross-talk (PHLPP) in cancer cells and in transforming growth factor β-activated stem cells. J Biol Chem 289 11601 PMID: 24599953

Shabir et al (2013) Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium. Naunyn Schmiedebergs Arch Pharmacol 305 F396 PMID: 23720349

Manohar et al (2012) ATP release and autocrine signaling through P2X4 receptors regulate γδ T cell activation. J Leukoc Biol 92 787 PMID: 22753954


Do you know of a great paper that uses TNP-ATP triethylammonium salt from Tocris? If so please let us know.

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