You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Discontinued ProductTMPH hydrochloride (Cat. No. 2438) has been withdrawn from sale for commercial reasons.
Biological Activity for TMPH hydrochloride
TMPH hydrochloride is a potent non-competitive antagonist of neuronal nicotinic ACh receptors (nAChRs). Produces long-lasting inhibition of neuronal nAChRs formed by the combination of the most abundant α and β subunits (i.e. α3, α4 and β2, β4 respectively). Displays little inhibition of muscle-type (α1β1γδ) or α7 receptors.
Sold under license from the University of Florida Research Foundation Inc.
Technical Data for TMPH hydrochloride
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TMPH hydrochloride
References for TMPH hydrochloride
References are publications that support the biological activity of the product.
Papke et al (2005) The effects of subunit composition on the inhibition of nicotinic receptors by the amphipathic blocker 2,2,6,6-tetramethylpiperidin-4-yl heptanoate. Mol.Pharmacol. 67 1977 PMID: 15761116
View Related Products by Target
View Related Products by Product Action
Keywords: TMPH hydrochloride, TMPH hydrochloride supplier, Neuronal, nicotinic, receptors, antagonists, Acetylcholine, Non-Selective, Subtypes, nAChR, Nicotinic, Receptors, (Non-selective), 2438, Tocris Bioscience
2 Citations for TMPH hydrochloride
Citations are publications that use Tocris products. Selected citations for TMPH hydrochloride include:
Peng et al (2013) Multiple modes of α7 nAChR noncompetitive antagonism of control agonist-evoked and allosterically enhanced currents. Mol Pharmacol 84 459 PMID: 23839567
Pinnock et al (2015) Nicotine receptors mediating sensorimotor gating and its enhancement by systemic nicotine. J Biomed Sci 9 30 PMID: 25717295
Reviews for TMPH hydrochloride
There are currently no reviews for this product. Be the first to review TMPH hydrochloride and earn rewards!
Have you used TMPH hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.