TMPH hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 2438 - TMPH hydrochloride | C16H31NO2.HCl | CAS No. 849461-91-2
Description: Neuronal nicotinic receptor antagonist
Chemical Name: 2,2,6,6-Tetramethylpiperidin-4-yl heptanoate
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent non-competitive antagonist of neuronal nicotinic ACh receptors (nAChRs). Produces long-lasting inhibition of neuronal nAChRs formed by the combination of the most abundant α and β subunits (i.e. α3, α4 and β2, β4 respectively). Displays little inhibition of muscle-type (α1β1γδ) or α7 receptors.

Licensing Information

Sold under license from the University of Florida Research Foundation Inc.

Compound Libraries

TMPH hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 305.88
Formula C16H31NO2.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 849461-91-2
PubChem ID 16079014
InChI Key XIDDVJIJIFWGIX-UHFFFAOYSA-N
Smiles CC1(C)NC(C)(C)CC(OC(CCCCCC)=O)C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.59 100
water 30.59 100

Preparing Stock Solutions

The following data is based on the product molecular weight 305.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.27 mL 16.35 mL 32.69 mL
5 mM 0.65 mL 3.27 mL 6.54 mL
10 mM 0.33 mL 1.63 mL 3.27 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Papke et al (2005) The effects of subunit composition on the inhibition of nicotinic receptors by the amphipathic blocker 2,2,6,6-tetramethylpiperidin-4-yl heptanoate. Mol.Pharmacol. 67 1977 PMID: 15761116


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View all Nicotinic Receptor (Non-selective) Antagonists

Keywords: Neuronal nicotinic receptors antagonists Acetylcholine Non-Selective Subtypes nAChR Nicotinic Receptors (Non-selective)

1 Citation for TMPH hydrochloride

Citations are publications that use Tocris products. Selected citations for TMPH hydrochloride include:

Pinnock et al (2015) Nicotine receptors mediating sensorimotor gating and its enhancement by systemic nicotine. J Biomed Sci 9 30 PMID: 25717295


Do you know of a great paper that uses TMPH hydrochloride from Tocris? If so please let us know.

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Literature in this Area

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Pathways for TMPH hydrochloride

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