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Submit ReviewTMPH hydrochloride
Description: Neuronal nAChR antagonist
Chemical Name: 2,2,6,6-Tetramethylpiperidin-4-yl heptanoate
Purity: ≥98% (HPLC)
Biological Activity
Potent non-competitive antagonist of neuronal nicotinic ACh receptors (nAChRs). Produces long-lasting inhibition of neuronal nAChRs formed by the combination of the most abundant α and β subunits (i.e. α3, α4 and β2, β4 respectively). Displays little inhibition of muscle-type (α1β1γδ) or α7 receptors.
Licensing Information
Sold under license from the University of Florida Research Foundation Inc.
Technical Data
| M. Wt | 305.88 |
| Formula | C16H31NO2.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 849461-91-2 |
| PubChem ID | 16079014 |
| InChI Key | XIDDVJIJIFWGIX-UHFFFAOYSA-N |
| Smiles | CC1(C)NC(C)(C)CC(OC(CCCCCC)=O)C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 30.59 | 100 | |
| DMSO | 30.59 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 305.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.27 mL | 16.35 mL | 32.69 mL |
| 5 mM | 0.65 mL | 3.27 mL | 6.54 mL |
| 10 mM | 0.33 mL | 1.63 mL | 3.27 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.65 mL |
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References
References are publications that support the biological activity of the product.
Papke et al (2005) The effects of subunit composition on the inhibition of nicotinic receptors by the amphipathic blocker 2,2,6,6-tetramethylpiperidin-4-yl heptanoate. Mol.Pharmacol. 67 1977 PMID: 15761116
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Keywords: TMPH hydrochloride, TMPH hydrochloride supplier, Neuronal, nicotinic, receptors, antagonists, Acetylcholine, Non-Selective, Subtypes, nAChR, Nicotinic, Receptors, (Non-selective), 2438, Tocris Bioscience
2 Citations for TMPH hydrochloride
Citations are publications that use Tocris products. Selected citations for TMPH hydrochloride include:
Peng et al (2013) Multiple modes of α7 nAChR noncompetitive antagonism of control agonist-evoked and allosterically enhanced currents. Mol Pharmacol 84 459 PMID: 23839567
Pinnock et al (2015) Nicotine receptors mediating sensorimotor gating and its enhancement by systemic nicotine. J Biomed Sci 9 30 PMID: 25717295
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