Potent non-competitive antagonist of neuronal nicotinic ACh receptors (nAChRs). Produces long-lasting inhibition of neuronal nAChRs formed by the combination of the most abundant α and β subunits (i.e. α3, α4 and β2, β4 respectively). Displays little inhibition of muscle-type (α1β1γδ) or α7 receptors.
Sold under license from the University of Florida Research Foundation Inc.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 305.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.27 mL||16.35 mL||32.69 mL|
|5 mM||0.65 mL||3.27 mL||6.54 mL|
|10 mM||0.33 mL||1.63 mL||3.27 mL|
|50 mM||0.07 mL||0.33 mL||0.65 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Papke et al (2005) The effects of subunit composition on the inhibition of nicotinic receptors by the amphipathic blocker 2,2,6,6-tetramethylpiperidin-4-yl heptanoate. Mol.Pharmacol. 67 1977 PMID: 15761116
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Keywords: TMPH hydrochloride, supplier, Neuronal, nicotinic, receptors, antagonists, Acetylcholine, Non-Selective, Subtypes, nAChR, Nicotinic, Receptors, (Non-selective), Nicotinic, Receptors, (Non-selective), Tocris Bioscience
1 Citation for TMPH hydrochloride
Citations are publications that use Tocris products. Selected citations for TMPH hydrochloride include:
Pinnock et al (2015) Nicotine receptors mediating sensorimotor gating and its enhancement by systemic nicotine. J Biomed Sci 9 30 PMID: 25717295
Do you know of a great paper that uses TMPH hydrochloride from Tocris? If so please let us know.
Literature in this Area
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.