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TMPH hydrochloride

Cat. No. 2438 2 Citations Submit a Review Datasheet / COA / SDS
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Cat.No. 2438 - TMPH hydrochloride | C16H31NO2.HCl | CAS No. 849461-91-2
Description: Neuronal nicotinic receptor antagonist
Chemical Name: 2,2,6,6-Tetramethylpiperidin-4-yl heptanoate
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent non-competitive antagonist of neuronal nicotinic ACh receptors (nAChRs). Produces long-lasting inhibition of neuronal nAChRs formed by the combination of the most abundant α and β subunits (i.e. α3, α4 and β2, β4 respectively). Displays little inhibition of muscle-type (α1β1γδ) or α7 receptors.

Licensing Information

Sold under license from the University of Florida Research Foundation Inc.

Compound Libraries

TMPH hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 305.88
Formula C16H31NO2.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 849461-91-2
PubChem ID 16079014
InChI Key XIDDVJIJIFWGIX-UHFFFAOYSA-N
Smiles CC1(C)NC(C)(C)CC(OC(CCCCCC)=O)C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 30.59 100
DMSO 30.59 100

Preparing Stock Solutions

The following data is based on the product molecular weight 305.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.27 mL 16.35 mL 32.69 mL
5 mM 0.65 mL 3.27 mL 6.54 mL
10 mM 0.33 mL 1.63 mL 3.27 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Papke et al (2005) The effects of subunit composition on the inhibition of nicotinic receptors by the amphipathic blocker 2,2,6,6-tetramethylpiperidin-4-yl heptanoate. Mol.Pharmacol. 67 1977 PMID: 15761116

If you know of a relevant reference for TMPH hydrochloride, please let us know.

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Keywords: TMPH hydrochloride, TMPH hydrochloride supplier, Neuronal, nicotinic, receptors, antagonists, Acetylcholine, Non-Selective, Subtypes, nAChR, Nicotinic, Receptors, (Non-selective), 2438, Tocris Bioscience

2 Citations for TMPH hydrochloride

Citations are publications that use Tocris products. Selected citations for TMPH hydrochloride include:

Pinnock et al (2015) Nicotine receptors mediating sensorimotor gating and its enhancement by systemic nicotine. J Biomed Sci 9 30 PMID: 25717295

Peng et al (2013) Multiple modes of α7 nAChR noncompetitive antagonism of control agonist-evoked and allosterically enhanced currents. Mol Pharmacol 84 459 PMID: 23839567

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Literature in this Area

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