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Submit ReviewPotent non-competitive antagonist of neuronal nicotinic ACh receptors (nAChRs). Produces long-lasting inhibition of neuronal nAChRs formed by the combination of the most abundant α and β subunits (i.e. α3, α4 and β2, β4 respectively). Displays little inhibition of muscle-type (α1β1γδ) or α7 receptors.
Sold under license from the University of Florida Research Foundation Inc.
M. Wt | 305.88 |
Formula | C16H31NO2.HCl |
Storage | Desiccate at RT |
Purity | ≥98% (HPLC) |
CAS Number | 849461-91-2 |
PubChem ID | 16079014 |
InChI Key | XIDDVJIJIFWGIX-UHFFFAOYSA-N |
Smiles | CC1(C)NC(C)(C)CC(OC(CCCCCC)=O)C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
water | 30.59 | 100 | |
DMSO | 30.59 | 100 |
The following data is based on the product molecular weight 305.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 3.27 mL | 16.35 mL | 32.69 mL |
5 mM | 0.65 mL | 3.27 mL | 6.54 mL |
10 mM | 0.33 mL | 1.63 mL | 3.27 mL |
50 mM | 0.07 mL | 0.33 mL | 0.65 mL |
References are publications that support the biological activity of the product.
Papke et al (2005) The effects of subunit composition on the inhibition of nicotinic receptors by the amphipathic blocker 2,2,6,6-tetramethylpiperidin-4-yl heptanoate. Mol.Pharmacol. 67 1977 PMID: 15761116
If you know of a relevant reference for TMPH hydrochloride, please let us know.
Keywords: TMPH hydrochloride, TMPH hydrochloride supplier, Neuronal, nicotinic, receptors, antagonists, Acetylcholine, Non-Selective, Subtypes, nAChR, Nicotinic, Receptors, (Non-selective), 2438, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for TMPH hydrochloride include:
Peng et al (2013) Multiple modes of α7 nAChR noncompetitive antagonism of control agonist-evoked and allosterically enhanced currents. Mol Pharmacol 84 459 PMID: 23839567
Pinnock et al (2015) Nicotine receptors mediating sensorimotor gating and its enhancement by systemic nicotine. J Biomed Sci 9 30 PMID: 25717295
Do you know of a great paper that uses TMPH hydrochloride from Tocris? Please let us know.
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.