TMPH hydrochloride
Biological Activity
Potent non-competitive antagonist of neuronal nicotinic ACh receptors (nAChRs). Produces long-lasting inhibition of neuronal nAChRs formed by the combination of the most abundant α and β subunits (i.e. α3, α4 and β2, β4 respectively). Displays little inhibition of muscle-type (α1β1γδ) or α7 receptors.
Licensing Information
Sold under license from the University of Florida Research Foundation Inc.
Compound Libraries
TMPH hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 305.88 |
| Formula | C16H31NO2.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 849461-91-2 |
| PubChem ID | 16079014 |
| InChI Key | XIDDVJIJIFWGIX-UHFFFAOYSA-N |
| Smiles | CC1(C)NC(C)(C)CC(OC(CCCCCC)=O)C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.59 | 100 | |
| water | 30.59 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 305.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.27 mL | 16.35 mL | 32.69 mL |
| 5 mM | 0.65 mL | 3.27 mL | 6.54 mL |
| 10 mM | 0.33 mL | 1.63 mL | 3.27 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.65 mL |
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References
References are publications that support the products' biological activity.
Papke et al (2005) The effects of subunit composition on the inhibition of nicotinic receptors by the amphipathic blocker 2,2,6,6-tetramethylpiperidin-4-yl heptanoate. Mol.Pharmacol. 67 1977 PMID: 15761116
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Keywords: Neuronal nicotinic receptors antagonists Acetylcholine Non-Selective Subtypes nAChR Nicotinic Receptors (Non-selective)
1 Citation for TMPH hydrochloride
Citations are publications that use Tocris products. Selected citations for TMPH hydrochloride include:
Pinnock et al (2015) Nicotine receptors mediating sensorimotor gating and its enhancement by systemic nicotine. J Biomed Sci 9 30 PMID: 25717295
Do you know of a great paper that uses TMPH hydrochloride from Tocris? If so please let us know.
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