TM 5275 sodium salt

Pricing Availability   Qty
Description: Plasminogen activator inhibitor-1 (PAI-1) inhibitor; orally bioavailable
Chemical Name: 5-Chloro-2-[[2-[2-[4-(Diphenylmethyl)-1-piperazinyl]-2-oxoethoxy]acetyl]amino]benzoic acid sodium salt
Purity: ≥98% (HPLC)
Citations (1)
Literature (1)

Biological Activity for TM 5275 sodium salt

TM 5275 sodium salt is a plasminogen activator inhibitor-1 (PAI-1) inhibitor. Orally bioavailable.

Compound Libraries for TM 5275 sodium salt

TM 5275 sodium salt is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TM 5275 sodium salt

M. Wt 543.97
Formula C28H27ClN3NaO5
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1103926-82-4
PubChem ID 53240409
Smiles O=C(COCC(NC4=C(C(O[Na])=O)C=C(Cl)C=C4)=O)N1CCN(C(C3=CC=CC=C3)C2=CC=CC=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TM 5275 sodium salt

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 54.4 100

Preparing Stock Solutions for TM 5275 sodium salt

The following data is based on the product molecular weight 543.97. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.84 mL 9.19 mL 18.38 mL
5 mM 0.37 mL 1.84 mL 3.68 mL
10 mM 0.18 mL 0.92 mL 1.84 mL
50 mM 0.04 mL 0.18 mL 0.37 mL

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Product Datasheets for TM 5275 sodium salt

References for TM 5275 sodium salt

References are publications that support the biological activity of the product.

Yamaoka et al (2011) Structure-activity relationships of new N-acylanthranilic acid derivatives as plasminogen activator inhibitor-1 inhibitors. Chem.Pharm.Bull. 59 215 PMID: 21297302

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1 Citation for TM 5275 sodium salt

Citations are publications that use Tocris products. Selected citations for TM 5275 sodium salt include:

Sun-Hee et al (2022) Secretory SERPINE1 Expression Is Increased by Antiplatelet Therapy, Inducing MMP1 Expression and Increasing Colon Cancer Metastasis. Int J Mol Sci 23 PMID: 36076991

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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