TM 5275 sodium salt

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Cat.No. 5769 - TM 5275 sodium salt | C28H27ClN3NaO5 | CAS No. 1103926-82-4
Description: Plasminogen activator inhibitor-1 (PAI-1) inhibitor; orally bioavailable
Chemical Name: 5-Chloro-2-[[2-[2-[4-(Diphenylmethyl)-1-piperazinyl]-2-oxoethoxy]acetyl]amino]benzoic acid sodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Plasminogen activator inhibitor-1 (PAI-1) inhibitor. Orally bioavailable.

Technical Data

M. Wt 543.97
Formula C28H27ClN3NaO5
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1103926-82-4
PubChem ID 53240409
InChI Key JSHSGBIWNPQCQZ-UHFFFAOYSA-M
Smiles O=C(COCC(NC4=C(C(O[Na])=O)C=C(Cl)C=C4)=O)N1CCN(C(C3=CC=CC=C3)C2=CC=CC=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 54.4 100

Preparing Stock Solutions

The following data is based on the product molecular weight 543.97. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.84 mL 9.19 mL 18.38 mL
5 mM 0.37 mL 1.84 mL 3.68 mL
10 mM 0.18 mL 0.92 mL 1.84 mL
50 mM 0.04 mL 0.18 mL 0.37 mL

Molarity Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Yamaoka et al (2011) Structure-activity relationships of new N-acylanthranilic acid derivatives as plasminogen activator inhibitor-1 inhibitors. Chem.Pharm.Bull. 59 215 PMID: 21297302


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Keywords: TM5275 sodium salt plasminogen activator inhibitors 1 PAI-1 inhibits orally bioavailable Other Proteases

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