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Biological Activity for TL 13-22
TL 13-22 is a negative control for TL 13-12 (Cat. No. 6744). Displays no degradation of ALK in cell lines. Highly potent inhibitor of ALK (IC50 = 0.54 nM)
Sold under license from Dana-Farber Cancer Institute
Technical Data for TL 13-22
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TL 13-22
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for TL 13-22
The following data is based on the product molecular weight 947.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.06 mL||5.28 mL||10.55 mL|
|5 mM||0.21 mL||1.06 mL||2.11 mL|
|10 mM||0.11 mL||0.53 mL||1.06 mL|
|50 mM||0.02 mL||0.11 mL||0.21 mL|
References for TL 13-22
References are publications that support the biological activity of the product.
Powell et al (2018) Chemically induced degradation of anaplastic lymphoma kinase (ALK). J.Med.Chem. 61 4249 PMID: 29660984
If you know of a relevant reference for TL 13-22, please let us know.
View Related Products by Target
Keywords: TL 13-22, TL 13-22 supplier, TL13-22, protacs, PROTAC, targeted, protein, degradation, TPD, degraders, ALK, Anaplastic, Lymphoma, Kinase, degronimides, negative, controls, Active, Degraders, 6747, Tocris Bioscience
Citations for TL 13-22
Citations are publications that use Tocris products.
Currently there are no citations for TL 13-22. Do you know of a great paper that uses TL 13-22 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Targeted Protein Degradation Research Product GuideUpdated
This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:
- Active Degraders
- TAG Degradation Platform
- Degrader Building Blocks
- Custom Degrader Services
- Ubiquitin-Proteasome System Proteins and Assays
- Assays for Protein Degradation
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Epigenetics in Cancer Poster
Adapted from the 2015 Cancer Product Guide Edition 3, this poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia