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Biological Activity for Tiplaxtinin
Tiplaxtinin is a plasminogen activator inhibitor-1 (PAI-1) inhibitor (IC50 = 2.7 μM). Induces vascular smooth muscle cell apoptosis in vitro and reduces carotid artery neointimal formation in a rat vascular injury model. Promotes thrombolysis in rat and dog models of acute arterial thrombosis. Orally available.
Compound Libraries for Tiplaxtinin
Technical Data for Tiplaxtinin
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Tiplaxtinin
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Tiplaxtinin
The following data is based on the product molecular weight 439.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.28 mL||11.38 mL||22.76 mL|
|5 mM||0.46 mL||2.28 mL||4.55 mL|
|10 mM||0.23 mL||1.14 mL||2.28 mL|
|50 mM||0.05 mL||0.23 mL||0.46 mL|
References for Tiplaxtinin
References are publications that support the biological activity of the product.
Elokdah et al (2004) Tiplaxtinin, a novel, orally efficacious inhibitor of plasminogen activator inhibitor-1: design, synthesis, and preclinical characterization. J.Med.Chem. 47 3491 PMID: 15214776
Simone et al (2015) A small molecule PAI-1 functional inhibitor attenuates neointimal hyperplasia and vascular smooth muscle cell survival by promoting PAI-1 cleavage. Cell.Signal. 27 923 PMID: 25617690
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Citations for Tiplaxtinin
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Literature in this Area
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