Ticlopidine hydrochloride

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Cat.No. 3931 - Ticlopidine hydrochloride | C14H14ClNS.HCl | CAS No. 53885-35-1
Description: Selective P2Y12 antagonist
Chemical Name: 5-[(2-Chlorophenyl)methyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective P2Y12 receptor antagonist. Inhibits ADP-induced platelet aggregation and displays antithrombotic activity following oral administration in vivo.

Technical Data

M. Wt 300.25
Formula C14H14ClNS.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 53885-35-1
PubChem ID 65335
InChI Key MTKNGOHFNXIVOS-UHFFFAOYSA-N
Smiles ClC(C=CC=C3)=C3CN1CCC2=C(C=CS2)C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.02 100
ethanol 22.52 75
water 30.02 100

Preparing Stock Solutions

The following data is based on the product molecular weight 300.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.33 mL 16.65 mL 33.31 mL
5 mM 0.67 mL 3.33 mL 6.66 mL
10 mM 0.33 mL 1.67 mL 3.33 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Michelson (2008) P2Y12 antagonism: promises and challenges. Arterioscler.Thromb.Vasc.Biol. 28 33 PMID:

Savi and Herbert (2005) Clopidogrel and ticlopidine: P2Y12 adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis. Semin.Thromb.Haemostas. 31 174 PMID:

Sharis et al (1998) The antiplatelet effects of ticlopidine and clopidogrel. Ann.Int.Med. 129 394 PMID:


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Citations for Ticlopidine hydrochloride

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Literature in this Area

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P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.

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Cardiovascular Poster

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Pathways for Ticlopidine hydrochloride

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