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Amino acid analog of glutamine and component of green tea. Shown to bind to AMPA, Kainate, NMDA and group I mGlu receptors. Displays neuroprotective effects in vivo. Promotes self-renewal of human embryonic stem cells (hESC).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 174.2. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.74 mL||28.7 mL||57.41 mL|
|5 mM||1.15 mL||5.74 mL||11.48 mL|
|10 mM||0.57 mL||2.87 mL||5.74 mL|
|50 mM||0.11 mL||0.57 mL||1.15 mL|
References are publications that support the biological activity of the product.
Kakuda et al (2002) Inhibition by theanine of binding of [3H]AMPA, [3H]kainate, and [3H]MDL 105,519 to glutamate receptors. Biosci.Biotechnol.Biochem. 66 2683 PMID: 12596867
Egashira et al (2008) Theanine prevents memory impairment induced by repeated cerebral ischemia in rats. Phytother.Res. 22 65 PMID: 17705146
Desbordes et al (2008) High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Cell Stem Cell. 2 602 PMID: 18522853
Nagasawa et al (2004) Possible involvement of group I mGluRs in neuroprotective effect of theanine. Biochem.Biophys.Res.Comm. 320 116
If you know of a relevant reference for Theanine, please let us know.
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Keywords: Theanine, Theanine supplier, glutamate, glutamine, analogue, receptors, metabotropic, mGlu, NMDA, Kainate, AMPA, ligands, hESC, human, embryonic, stem, cells, Miscellaneous, Glutamate, Stem, Cell, Proliferation, 3847, Tocris Bioscience
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Learning & Memory Poster
Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.