Theanine

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Cat.No. 3847 - Theanine | C7H14N2O3 | CAS No. 3081-61-6
Description: Glutamate receptor ligand
Chemical Name: N-Ethyl-L-glutamine
Datasheet
Citations
Literature

Biological Activity

Amino acid analog of glutamine and component of green tea. Shown to bind to AMPA, Kainate, NMDA and group I mGlu receptors. Displays neuroprotective effects in vivo. Promotes self-renewal of human embryonic stem cells (hESC).

Technical Data

M. Wt 174.2
Formula C7H14N2O3
Storage Store at RT
CAS Number 3081-61-6
PubChem ID 439378
InChI Key DATAGRPVKZEWHA-YFKPBYRVSA-N
Smiles CCNC(CC[C@H](N)C(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 17.42 100

Preparing Stock Solutions

The following data is based on the product molecular weight 174.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.74 mL 28.7 mL 57.41 mL
5 mM 1.15 mL 5.74 mL 11.48 mL
10 mM 0.57 mL 2.87 mL 5.74 mL
50 mM 0.11 mL 0.57 mL 1.15 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Kakuda et al (2002) Inhibition by theanine of binding of [3H]AMPA, [3H]kainate, and [3H]MDL 105,519 to glutamate receptors. Biosci.Biotechnol.Biochem. 66 2683 PMID: 12596867

Egashira et al (2008) Theanine prevents memory impairment induced by repeated cerebral ischemia in rats. Phytother.Res. 22 65 PMID: 17705146

Desbordes et al (2008) High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Cell Stem Cell. 2 602 PMID: 18522853

Nagasawa et al (2004) Possible involvement of group I mGluRs in neuroprotective effect of theanine. Biochem.Biophys.Res.Comm. 320 116 PMID:


If you know of a relevant reference for Theanine, please let us know.

Keywords: glutamate glutamine analogue receptors metabotropic mGlu NMDA Kainate AMPA ligands hESC human embryonic stem cells Miscellaneous Glutamate

Citations for Theanine

Citations are publications that use Tocris products.

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Pathways for Theanine

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