TH 5427 hydrochloride

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Description: Potent NUDT5 inhibitor
Chemical Name: 7-[[5-(3,4-Dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-1,3-dimethyl-8-(piperazine-1-yl)-1H-purine-2,6-dione hydrochloride
Purity: ≥98% (HPLC)

Biological Activity for TH 5427 hydrochloride

TH 5427 hydrochloride is a potent nudix hydrolase 5 (NUDT5) inhibitor (IC50 = 29 nM). Displays >650-fold selectivity for NUDT5 over MTH1. Inhibits ATP synthesis, chromatin remodeling, gene expression and proliferation in progestin-treated breast cancer cells in vitro.

Licensing Information

Sold under license from Thomas Helleday's Foundation for Medical Research and Oxcia AB.

Compound Libraries for TH 5427 hydrochloride

TH 5427 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TH 5427 hydrochloride

M. Wt 527.79
Formula C20H20Cl2N8O3.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 2253744-57-7
PubChem ID 137919865
Smiles O=C1N(C)C(C(N(CC2=NN=C(C3=CC(Cl)=C(Cl)C=C3)O2)C(N4CCNCC4)=N5)=C5N1C)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TH 5427 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 5.28 10
DMSO 10.56 20

Preparing Stock Solutions for TH 5427 hydrochloride

The following data is based on the product molecular weight 527.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 9.47 mL 47.37 mL 94.73 mL
1 mM 1.89 mL 9.47 mL 18.95 mL
2 mM 0.95 mL 4.74 mL 9.47 mL
10 mM 0.19 mL 0.95 mL 1.89 mL

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Product Datasheets for TH 5427 hydrochloride

Certificate of Analysis / Product Datasheet
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References for TH 5427 hydrochloride

References are publications that support the biological activity of the product.

Page et al (2018) Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells. Nat.Commun. 9 250 PMID: 29343827

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Citations for TH 5427 hydrochloride

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