You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
TH 5427 hydrochloride
Potent nudix hydrolase 5 (NUDT5) inhibitor (IC50 = 29 nM). Displays >650-fold selectivity for NUDT5 over MTH1. Inhibits ATP synthesis, chromatin remodeling, gene expression and proliferation in progestin-treated breast cancer cells in vitro.
Sold under license from Thomas Helleday's Foundation for Medical Research and Oxcia AB.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 527.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.89 mL||9.47 mL||18.95 mL|
|5 mM||0.38 mL||1.89 mL||3.79 mL|
|10 mM||0.19 mL||0.95 mL||1.89 mL|
|50 mM||0.04 mL||0.19 mL||0.38 mL|
References are publications that support the biological activity of the product.
Page et al (2018) Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells. Nat.Commun. 9 250 PMID: 29343827
If you know of a relevant reference for TH 5427 hydrochloride, please let us know.
View Related Products by Product Action
Keywords: TH 5427 hydrochloride, TH 5427 hydrochloride supplier, TH5427, HCl, nudix, hydrolase, 5, inhibitors, inhibits, potent, selective, NUDT5, breast, cancer, proliferation, Other, Hydrolases, 6534, Tocris Bioscience
Citations for TH 5427 hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for TH 5427 hydrochloride. Do you know of a great paper that uses TH 5427 hydrochloride from Tocris? Please let us know.
Reviews for TH 5427 hydrochloride
There are currently no reviews for this product. Be the first to review TH 5427 hydrochloride and earn rewards!
Have you used TH 5427 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
New Product Guide (Fall/Winter 2018/2019)
Our new product guide highlights over 190 new products added to the Tocris Bioscience range during the second half of 2018.
- 7-TM Receptors
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Fluorescent Imaging
- Signal Transduction
- Stem Cells