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Submit ReviewTH 257
Description: Potent and selective allosteric LIMK 1/2 inhibitor
Chemical Name: N-Butyl-4-[(phenylamino)sulfonyl]-N-(phenylmethyl)benzamide
Purity: ≥98% (HPLC)
Biological Activity for TH 257
TH 257 is a potent and selective allosteric LIMK 1/2 inhibitor (IC50 values are 84 and 39 nM, respectively). Inhibits cofilin phosphorylation in vitro. Exhibits no significant activity against the wider kinome.
Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the TH 257 probe summary on the SGC website.
Compound Libraries for TH 257
TH 257 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for TH 257
| M. Wt | 422.54 |
| Formula | C24H26N2O3S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2244678-29-1 |
| InChI Key | VNCIWNGCMAKKEO-UHFFFAOYSA-N |
| Smiles | CCCCN(CC1=CC=CC=C1)C(=O)C1=CC=C(C=C1)[S](=O)(=O)NC1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TH 257
References for TH 257
References are publications that support the biological activity of the product.
Manetti et al (2018) Recent advances in the rational design and development of LIM kinase inhibitors are not enough to enter clinical trials. Eur.J.Med.Chem. 155 445 PMID: 29908439
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Keywords: TH 257, TH 257 supplier, TH257, Potent, selective, LIMK1/2, LIMK1, LIMK2, inhibitors, inhibits, lim, kinases, LIMK, 6899, Tocris Bioscience
Citations for TH 257
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Currently there are no citations for TH 257.
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