TH 257

Pricing Availability   Qty
Cat.No. 6899 - TH 257 | C24H26N2O3S | CAS No. 2244678-29-1
Description: Potent and selective allosteric LIMK 1/2 inhibitor
Chemical Name: N-Butyl-4-[(phenylamino)sulfonyl]-N-(phenylmethyl)benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity for TH 257

TH 257 is a potent and selective allosteric LIMK 1/2 inhibitor (IC50 values are 84 and 39 nM, respectively). Inhibits cofilin phosphorylation in vitro. Exhibits no significant activity against the wider kinome.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the TH 257 probe summary on the SGC website.

Compound Libraries for TH 257

TH 257 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TH 257

M. Wt 422.54
Formula C24H26N2O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 2244678-29-1
InChI Key VNCIWNGCMAKKEO-UHFFFAOYSA-N
Smiles CCCCN(CC1=CC=CC=C1)C(=O)C1=CC=C(C=C1)[S](=O)(=O)NC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TH 257

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.25 100
ethanol 42.25 100

Preparing Stock Solutions for TH 257

The following data is based on the product molecular weight 422.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.37 mL 11.83 mL 23.67 mL
5 mM 0.47 mL 2.37 mL 4.73 mL
10 mM 0.24 mL 1.18 mL 2.37 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for TH 257

References are publications that support the biological activity of the product.

Manetti et al (2018) Recent advances in the rational design and development of LIM kinase inhibitors are not enough to enter clinical trials. Eur.J.Med.Chem. 155 445 PMID: 29908439


If you know of a relevant reference for TH 257, please let us know.

View Related Products by Target

View Related Products by Product Action

View all LIMK Inhibitors

Keywords: TH 257, TH 257 supplier, TH257, Potent, selective, LIMK1/2, LIMK1, LIMK2, inhibitors, inhibits, lim, kinases, LIMK, 6899, Tocris Bioscience

Citations for TH 257

Citations are publications that use Tocris products.

Currently there are no citations for TH 257. Do you know of a great paper that uses TH 257 from Tocris? Please let us know.

Reviews for TH 257

There are currently no reviews for this product. Be the first to review TH 257 and earn rewards!

Have you used TH 257?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases Product Listing

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Neurodegeneration Product Guide

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.