TG 100713

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Cat.No. 4264 - TG 100713 | C12H10N6O | CAS No. 925705-73-3
Description: PI 3-kinase inhibitor
Chemical Name: 3-(2,4-Diamino-6-pteridinyl)-phenol
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Inhibitor of PI3-kinase (IC50 values are 24, 50, 165 and 215 nM for PI3Kδ, γ, α and β isoforms respectively). Inhibits endothelial cell proliferation.

Technical Data

M. Wt 254.25
Formula C12H10N6O
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 925705-73-3
PubChem ID 17751063
InChI Key UOORQSPLBHUQDQ-UHFFFAOYSA-N
Smiles NC1=NC(N)=C2C(N=CC(C3=CC=CC(O)=C3)=N2)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 2.54 10

Preparing Stock Solutions

The following data is based on the product molecular weight 254.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.93 mL 19.67 mL 39.33 mL
5 mM 0.79 mL 3.93 mL 7.87 mL
10 mM 0.39 mL 1.97 mL 3.93 mL
50 mM 0.08 mL 0.39 mL 0.79 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Doukas et al (2006) Phosphoinositide 3-kinase γ/δ inhibition limits infarct size after myocardial ischemia/reperfusion injury. Proc.Natl.Acad.Sci.USA 103 19866 PMID: 17172449

Palanki et al (2007) Discovery of 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol as an isozyme-selective inhibitor of PI3K for the treatment of ischemia reperfusion injury associated with myocardial infarction. J.Med.Chem. 50 4279 PMID: 17685602


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Citations for TG 100713

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Pathways for TG 100713

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