TG 100713

Discontinued Product

TG 100713 (Cat. No. 4264) has been withdrawn from sale for commercial reasons.
Cat.No. 4264 - TG 100713 | C12H10N6O | CAS No. 925705-73-3
Description: PI 3-kinase inhibitor
Chemical Name: 3-(2,4-Diamino-6-pteridinyl)-phenol
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity

Inhibitor of PI3-kinase (IC50 values are 24, 50, 165 and 215 nM for PI3Kδ, γ, α and β isoforms respectively). Inhibits endothelial cell proliferation.

Technical Data

M. Wt 254.25
Formula C12H10N6O
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 925705-73-3
PubChem ID 17751063
InChI Key UOORQSPLBHUQDQ-UHFFFAOYSA-N
Smiles NC1=NC(N)=C2C(N=CC(C3=CC=CC(O)=C3)=N2)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Doukas et al (2006) Phosphoinositide 3-kinase γ/δ inhibition limits infarct size after myocardial ischemia/reperfusion injury. Proc.Natl.Acad.Sci.USA 103 19866 PMID: 17172449

Palanki et al (2007) Discovery of 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol as an isozyme-selective inhibitor of PI3K for the treatment of ischemia reperfusion injury associated with myocardial infarction. J.Med.Chem. 50 4279 PMID: 17685602

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Keywords: TG 100713, TG 100713 supplier, TG100713, pi3k, pi3kd, pi3kdelta, pi3kδ, pi3kgamma, pi3kg, pi3kγ, pi3kalpha, pi3ka, pi3kα, pi3kbeta, pi3kb, ip3kβ, inhibitors, inhibits, PI, 3-Kinase, 4264, Tocris Bioscience

Citations for TG 100713

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Currently there are no citations for TG 100713.

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Literature in this Area

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