TFAX 546, SE

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Cat.No. 6623 - TFAX 546, SE | C44H47Cl3N4O14S.(CH3CH2)3NH
Description: Yellow fluorescent dye; amine reactive
Chemical Name: 6-[2-Carboxy-3,4,6-trichloro-5-[[2-[[6-[(2,5-dioxo-1-pyrrolidinyl)oxy]-6-oxohexyl]amino]-2-oxoethyl]thio]phenyl]-1,2,3,4,8,9,10,11-octahydro-2,2,4,8,10,10-hexamethyl-12,14-disulfopyrano[3,2-g:5,6-g']diquinolin-13-ium triethylammonium salt
Datasheet
Citations
Reviews
Literature

Biological Activity

Amine reactive yellow fluorescent dye. Insensitive to pH in the range 4 - 10. Forms bright and photostable conjugates with proteins and antibodies. Suitable for use in microscopy. Excitation maximum = 554 nm; emission maximum = 570 nm; extinction coefficient = 112,000 M-1cm-1; quantum yield = 0.79.

Optical Data for TFAX 546, SE

Emission Color Yellow
Brightness
λabs 554 nm
λem 570 nm
Extinction Coefficient (ε) 112000 M-1cm-1
Quantum Yield (φ) 0.79
Closest Laser line 532 nm
Reactive Group NHS ester
Reactivity Primary amines
Cell Permeable No
pH Sensitivity pH insensitive pH 4-10
Application microscopy
Alternative For TMR, Cyanine3, Alexa Fluor 546 SE, AF 546 SE

Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company.

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Technical Data

M. Wt 1159.6
Formula C44H47Cl3N4O14S.(CH3CH2)3NH
Storage Store at -20°C
Smiles ClC(C(Cl)=C1C(O)=O)=C(SCC(NCCCCCC(ON2C(CCC2=O)=O)=O)=O)C(Cl)=C1C(C3=CC4=C(NC(C)(C)CC4C)C(S(=O)([O-])=O)=C3O5)=C6C5=C(S(=O)([O-])=O)C7=[NH+]C(C)(C)CC(C)C7=C6.CC[NH+](CC)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble in DMSO

References

References are publications that support the biological activity of the product.

Hone et al (2010) Alexa Fluor 546-ArIB[V11L;V16A] is a potent ligand for selectively labeling α 7 nicotinic acetylcholine receptors. J.Neurochem. 114 994 PMID: 20492354

Iwata et al (2005) Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation. Proc.Natl.Acad.Sci.USA. 102 13135 PMID: 16141322

Panchuk-Voloshina et al (1999) Alexa dyes, a series of new fluorescent dyes that yield exceptionally bright, photostable conjugates. J.Histochem.Cytochem. 47 1179 PMID: 10449539


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