(-)-Terreic acid

Pricing Availability Delivery Time Qty
Cat.No. 1405 - Terreic acid | C7H6O4 | CAS No. 121-40-4
Description: Selective inhibitor of BTK
Chemical Name: (1R,6S)-3-Hydroxy-4-methyl-7-oxabicyclo[4.1.0]hept-3-ene-2,5-dione
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective inhibitor of Bruton's tyrosine kinase (BTK). Inhibits the interaction between PKCbII and BTK (IC50 ~ 30 mM) and the catalytic activity of BTK but does not affect the activity of PKC. Has little effect on the activities of Lyn, Syk, PKA, casein kinase I, ERK1, ERK2 and p38 kinases.

Technical Data

M. Wt 154.12
Formula C7H6O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 121-40-4
PubChem ID 91437
InChI Key ATFNSNUJZOYXFC-RQJHMYQMSA-N
Smiles CC1=C(O)C(=O)[C@@H]2O[C@@H]2C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 3.08 20

Preparing Stock Solutions

The following data is based on the product molecular weight 154.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.49 mL 32.44 mL 64.88 mL
5 mM 1.3 mL 6.49 mL 12.98 mL
10 mM 0.65 mL 3.24 mL 6.49 mL
50 mM 0.13 mL 0.65 mL 1.3 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Kawakami et al (1999) Terreic acid, a quinone epoxide inhibitor of Bruton's tyrosine kinase. Proc.Natl.Acad.Sci.U.S.A. 96 2227 PMID: 10051623

Subramanian et al (1982) In vivo and in vitro studies on the binding nature of terreic acid with macromolecules such as protein and nucleic acids. Toxicol.Lett. 10 249 PMID: 7080093

Yamamoto et al (1980) Studies on terreic acid. Jpn.J.Antibiot. 33 320 PMID: 7190624


If you know of a relevant reference for (-)-Terreic acid, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Bruton's Tyrosine Kinase Inhibitors

Keywords: Terreic acid, supplier, Selective, inhibitors, inhibits, BTK, Brutons, Tyrosine, Kinases, Brutons, Tyrosine, Kinase, (BTK), Tocris Bioscience

Citations for (-)-Terreic acid

Citations are publications that use Tocris products.

Currently there are no citations for (-)-Terreic acid. Do you know of a great paper that uses (-)-Terreic acid from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Pathways for (-)-Terreic acid

Protocols

TODO: Add Protocols