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Selective inhibitor of Bruton's tyrosine kinase (BTK). Inhibits the interaction between PKCbII and BTK (IC50 ~ 30 mM) and the catalytic activity of BTK but does not affect the activity of PKC. Has little effect on the activities of Lyn, Syk, PKA, casein kinase I, ERK1, ERK2 and p38 kinases.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 154.12. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||32.44 mL||162.21 mL||324.42 mL|
|1 mM||6.49 mL||32.44 mL||64.88 mL|
|2 mM||3.24 mL||16.22 mL||32.44 mL|
|10 mM||0.65 mL||3.24 mL||6.49 mL|
References are publications that support the biological activity of the product.
Kawakami et al (1999) Terreic acid, a quinone epoxide inhibitor of Bruton's tyrosine kinase. Proc.Natl.Acad.Sci.U.S.A. 96 2227 PMID: 10051623
Subramanian et al (1982) In vivo and in vitro studies on the binding nature of terreic acid with macromolecules such as protein and nucleic acids. Toxicol.Lett. 10 249 PMID: 7080093
Yamamoto et al (1980) Studies on terreic acid. Jpn.J.Antibiot. 33 320 PMID: 7190624
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Keywords: Terreic acid, Terreic acid supplier, Selective, inhibitors, inhibits, BTK, Brutons, Tyrosine, Kinases, Kinase, (BTK), 1405, Tocris Bioscience
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