(-)-Terreic acid

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Cat.No. 1405 - Terreic acid | C7H6O4 | CAS No. 121-40-4
Description: Selective inhibitor of BTK
Chemical Name: (1R,6S)-3-Hydroxy-4-methyl-7-oxabicyclo[4.1.0]hept-3-ene-2,5-dione
Purity: ≥99% (HPLC)
Literature (3)

Biological Activity for (-)-Terreic acid

(-)-Terreic acid is a selective inhibitor of Bruton's tyrosine kinase (BTK). Inhibits the interaction between PKCbII and BTK (IC50 ~ 30 mM) and the catalytic activity of BTK but does not affect the activity of PKC. Has little effect on the activities of Lyn, Syk, PKA, casein kinase I, ERK1, ERK2 and p38 kinases.

Technical Data for (-)-Terreic acid

M. Wt 154.12
Formula C7H6O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 121-40-4
PubChem ID 91437
Smiles CC1=C(O)C(=O)[C@@H]2O[C@@H]2C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (-)-Terreic acid

Solvent Max Conc. mg/mL Max Conc. mM
water 3.08 20

Preparing Stock Solutions for (-)-Terreic acid

The following data is based on the product molecular weight 154.12. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 32.44 mL 162.21 mL 324.42 mL
1 mM 6.49 mL 32.44 mL 64.88 mL
2 mM 3.24 mL 16.22 mL 32.44 mL
10 mM 0.65 mL 3.24 mL 6.49 mL

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Product Datasheets for (-)-Terreic acid

References for (-)-Terreic acid

References are publications that support the biological activity of the product.

Kawakami et al (1999) Terreic acid, a quinone epoxide inhibitor of Bruton's tyrosine kinase. Proc.Natl.Acad.Sci.U.S.A. 96 2227 PMID: 10051623

Subramanian et al (1982) In vivo and in vitro studies on the binding nature of terreic acid with macromolecules such as protein and nucleic acids. Toxicol.Lett. 10 249 PMID: 7080093

Yamamoto et al (1980) Studies on terreic acid. Jpn.J.Antibiot. 33 320 PMID: 7190624

If you know of a relevant reference for (-)-Terreic acid, please let us know.

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Keywords: Terreic acid, Terreic acid supplier, Selective, inhibitors, inhibits, BTK, Brutons, Tyrosine, Kinases, Kinase, (BTK), 1405, Tocris Bioscience

Citations for (-)-Terreic acid

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