Tenovin-1

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Cat.No. 3365 - Tenovin-1 | C20H23N3O2S | CAS No. 380315-80-0
Description: Protects against MDM2-mediated p53 degradation
Chemical Name: N-[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

p53 activator that protects against MDM2-mediated p53 degradation. Elevates levels of p53 and p21CIP/WAF1 and induces expression from an endogenous p53-dependent promoter. Exhibits potent antiproliferative activity in vitro.

Compound Libraries

Tenovin-1 is also offered as part of the Tocriscreen Plus and Tocriscreen Epigenetics Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 369.48
Formula C20H23N3O2S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 380315-80-0
PubChem ID 1013376
InChI Key WOWJIWFCOPZFGV-UHFFFAOYSA-N
Smiles CC(C)(C)C1=CC=C(C(NC(NC2=CC=C(NC(C)=O)C=C2)=S)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.24 25
ethanol 1.85 5

Preparing Stock Solutions

The following data is based on the product molecular weight 369.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.71 mL 13.53 mL 27.07 mL
5 mM 0.54 mL 2.71 mL 5.41 mL
10 mM 0.27 mL 1.35 mL 2.71 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Lain et al (2008) Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell 13 454 PMID: 18455128


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Keywords: Tenovin-1, supplier, activators, p53, transcriptional, activity, Protects, against, MDM2-mediated, degradation, Transcription, Factors, Ligases, p53, Ubiquitin, E3, Ligases, Ubiquitin, E3, Ligases, Tocris Bioscience

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