Tenofovir

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Cat.No. 3666 - Tenofovir | C9H14N5O4P | CAS No. 147127-20-6
Description: Reverse transcriptase inhibitor
Alternative Names: PMPA, (R)-9-(2-Phosphonoylmethoxypropyl)adenine
Chemical Name: (R)-[[2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic acid
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selectively inhibits HIV reverse transcriptase (RNA-dependent DNA polymerase). Prevents cytotoxicity in SIV-infected C-8166 cells in vitro (IC50 = 1.5 μM). Antiviral agent.

Technical Data

M. Wt 287.21
Formula C9H14N5O4P
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 147127-20-6
PubChem ID 464205
InChI Key SGOIRFVFHAKUTI-ZCFIWIBFSA-N
Smiles C[C@@H](OCP(O)(O)=O)CN(C=N2)C1=C2C(N)=NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1.1eq. NaOH 28.72 100
DMSO 2.87 10

Preparing Stock Solutions

The following data is based on the product molecular weight 287.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.48 mL 17.41 mL 34.82 mL
5 mM 0.7 mL 3.48 mL 6.96 mL
10 mM 0.35 mL 1.74 mL 3.48 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Tsai et al (1995) Prevention of SIV infection in macaques by (R)-9-(2-phosphonylmethoxypropyl)adenine. Science 270 1197 PMID: 7502044

Van Rompay et al (1996) 9-[2-(Phosphonomethoxy)propyl]adenine therapy of established simian immunodeficiency virus infection in infant rhesus macaques. Antimicrob.Agents Chemother. 40 2586 PMID: 8913470

Suo et al (1998) Selective inhibition of HIV-1 reverse transcriptase by an antiviral inhibitor, (R)-9-(2-phosphonylmethoxypropyl)adenine. J.Biol.Chem. 273 27250 PMID: 9765248


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Citations for Tenofovir

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