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Selectively inhibits HIV reverse transcriptase (RNA-dependent DNA polymerase). Prevents cytotoxicity in SIV-infected C-8166 cells in vitro (IC50 = 1.5 μM). Antiviral agent.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 287.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.48 mL||17.41 mL||34.82 mL|
|5 mM||0.7 mL||3.48 mL||6.96 mL|
|10 mM||0.35 mL||1.74 mL||3.48 mL|
|50 mM||0.07 mL||0.35 mL||0.7 mL|
References are publications that support the biological activity of the product.
Tsai et al (1995) Prevention of SIV infection in macaques by (R)-9-(2-phosphonylmethoxypropyl)adenine. Science 270 1197 PMID: 7502044
Van Rompay et al (1996) 9-[2-(Phosphonomethoxy)propyl]adenine therapy of established simian immunodeficiency virus infection in infant rhesus macaques. Antimicrob.Agents Chemother. 40 2586 PMID: 8913470
Suo et al (1998) Selective inhibition of HIV-1 reverse transcriptase by an antiviral inhibitor, (R)-9-(2-phosphonylmethoxypropyl)adenine. J.Biol.Chem. 273 27250 PMID: 9765248
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Keywords: Tenofovir, Tenofovir supplier, Reverse, transcriptase, inhibitors, inhibits, Polymerases, RNA/DNA, Polymerase, antivirals, antiretrovirals, PMPA, (R)-9-(2-Phosphonoylmethoxypropyl)adenine, DNA, HIV, 3666, Tocris Bioscience
Citations for Tenofovir
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Reviews for Tenofovir
Average Rating: 5 (Based on 1 Review.)
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We studied in vivo tenofovir breakdown.How it is converted to tenofovir.Tenofovir lacks a hydroxyl group in the position corresponding to the 3' carbon of the d-AMP and tenofovir was observed to cause premature termination of DNA transcription, preventing viral replication.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.