Selectively inhibits HIV reverse transcriptase (RNA-dependent DNA polymerase). Prevents cytotoxicity in SIV-infected C-8166 cells in vitro (IC50 = 1.5 μM). Antiviral agent.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 287.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.48 mL||17.41 mL||34.82 mL|
|5 mM||0.7 mL||3.48 mL||6.96 mL|
|10 mM||0.35 mL||1.74 mL||3.48 mL|
|50 mM||0.07 mL||0.35 mL||0.7 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Tsai et al (1995) Prevention of SIV infection in macaques by (R)-9-(2-phosphonylmethoxypropyl)adenine. Science 270 1197 PMID: 7502044
Van Rompay et al (1996) 9-[2-(Phosphonomethoxy)propyl]adenine therapy of established simian immunodeficiency virus infection in infant rhesus macaques. Antimicrob.Agents Chemother. 40 2586 PMID: 8913470
Suo et al (1998) Selective inhibition of HIV-1 reverse transcriptase by an antiviral inhibitor, (R)-9-(2-phosphonylmethoxypropyl)adenine. J.Biol.Chem. 273 27250 PMID: 9765248
If you know of a relevant reference for Tenofovir, please let us know.
View Related Products by Product Action
Keywords: Reverse transcriptase inhibitors inhibits Polymerases RNA/DNA Polymerase antivirals antiretrovirals PMPA (R)-9-(2-Phosphonoylmethoxypropyl)adenine RNA/DNA Polymerase
Citations for Tenofovir
Citations are publications that use Tocris products.
Currently there are no citations for Tenofovir. Do you know of a great paper that uses Tenofovir from Tocris? If so please let us know.