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Description: DNA topoisomerase II inhibitor; viral transduction enhancer
Chemical Name: (5R,5aR,8aR,9S)-5,8,8a,9-Tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-[(R)-2-thienylmethylene]-β-D-glucopyranosyl]oxy]furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
Purity: ≥98% (HPLC)
Biological Activity for Teniposide
Teniposide is a DNA topoisomerase II inhibitor and viral transduction enhancer. It induces breaks in double-stranded DNA and prevents DNA repair. Teniposide enhances transduction of recombinant adeno-associated virus 2 (rAAV2) by up to 40-fold in human cells in vitro and by 100-fold in vivo at 24 h post-transduction.
Technical Data for Teniposide
| M. Wt | 656.66 |
| Formula | C32H32O13S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 29767-20-2 |
| PubChem ID | 452548 |
| InChI Key | NRUKOCRGYNPUPR-QBPJDGROSA-N |
| Smiles | [H][C@]12COC(=O)[C@]1([H])[C@H](C1=CC(OC)=C(O)C(OC)=C1)C1=CC3=C(OCO3)C=C1[C@H]2O[C@]1([H])O[C@]2([H])CO[C@H](O[C@@]2([H])[C@H](O)[C@H]1O)C1=CC=CS1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Teniposide
References for Teniposide
References are publications that support the biological activity of the product.
Nicolson et al (2016) Identification and validation of small molecules that enhance recombinant adeno-associated virus transduction following high-throughput screens. J.Virol. 90 7019 PMID: 27147738
Yusenko et al (2018) A novel cell-based screening assay for small-molecule MYB inhibitors identifies podophyllotoxins teniposide and etoposide as inhibitors of MYB activity. Sci.Rep. 8 13159 PMID: 30177851
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Keywords: Teniposide, Teniposide supplier, DNA, topoisomerase, II, inhibitors, viral, transduction, enhancers, adeno-associated, virus, 2, Viral, Transduction, Enhancers, Topoisomerase, 6975, Tocris Bioscience
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Huntington's Disease Research Product Guide
This product guide provides a background to Huntington's disease research and lists around 100 products for the study of:
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