Tempol

Pricing Availability Delivery Time Qty
Cat.No. 3082 - Tempol | C9H18NO2 | CAS No. 2226-96-2
Description: Superoxide scavenger; antioxidant
Chemical Name: 1-Oxyl-2,2,6,6-tetramethyl-4-hydroxypiperidine
Purity: ≥99%
Datasheet
Citations (5)
Literature

Biological Activity

Superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects.

Technical Data

M. Wt 172.24
Formula C9H18NO2
Storage Store at -20°C
Purity ≥99%
CAS Number 2226-96-2
PubChem ID 137994
InChI Key UZFMOKQJFYMBGY-UHFFFAOYSA-N
Smiles CC1(C)CC(O)CC(C)(C)N1[O]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 17.22 100
ethanol 17.22 100

Preparing Stock Solutions

The following data is based on the product molecular weight 172.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.81 mL 29.03 mL 58.06 mL
5 mM 1.16 mL 5.81 mL 11.61 mL
10 mM 0.58 mL 2.9 mL 5.81 mL
50 mM 0.12 mL 0.58 mL 1.16 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Francis and Sehgal (2006) The superoxide scavenger TEMPOL induces urokinase receptor (uPAR) expression in human prostate cancer cells. Mol.Cancer 5 21 PMID: 16756681

Deng-Bryant et al (2008) Neuroprotective effect of tempol, a catalytic scavenger of peroxynitrite-derived free radicals, in a mouse traumatic brain injury model. J.Cereb.Blood Flow Metab. 28 1114 PMID: 18319733

Khattab (2006) TEMPOL, a membrane-permeable radical scavenger, attenuates peroxynitrite- and superoxide anion-enhanced carrageenan-induced paw edema and hyperalgesia: a key role for superoxide anion. EurJ.Pharmacol. 548 167 PMID:


If you know of a relevant reference for Tempol, please let us know.

View Related Products by Target

Keywords: Tempol, supplier, Superoxide, scavenger, antioxidant, Antioxidants, Antioxidants, Tocris Bioscience

5 Citations for Tempol

Citations are publications that use Tocris products. Selected citations for Tempol include:

Tomasovic et al (2015) Sestrin 2 Regulates PDGF Receptor β (PDGFRβ) Expression by Modulating Proteasomal and Nrf2 Transcription Factor Functions. Brain Res NULL PMID: 25716320

Senturk et al (2014) p53ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state. Proc Natl Acad Sci U S A 111 E3287 PMID: 25074920

Nesuashvili et al (2013) Sensory nerve terminal mitochondrial dysfunction activates airway sensory nerves via transient receptor potential (TRP) channels. Mol Pharmacol 83 1007 PMID: 23444014

Valente et al (2012) Angiotensin II enhances AT1-Nox1 binding and stimulates arterial smooth muscle cell migration and proliferation through AT1, Nox1, and interleukin-18. Am J Physiol Heart Circ Physiol 303 H282 PMID: 22636674

Ruparel et al (2012) Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation. J Biol Chem 153 2031 PMID: 22633978


Do you know of a great paper that uses Tempol from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for Tempol

Protocols

TODO: Add Protocols