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Cat.No. 3082 - Tempol | C9H18NO2 | CAS No. 2226-96-2
Description: Superoxide scavenger; antioxidant
Chemical Name: 1-Oxyl-2,2,6,6-tetramethyl-4-hydroxypiperidine
Purity: ≥99%
Citations (5)

Biological Activity

Superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects.

Technical Data

M. Wt 172.24
Formula C9H18NO2
Storage Store at -20°C
Purity ≥99%
CAS Number 2226-96-2
PubChem ID 137994
Smiles CC1(C)CC(O)CC(C)(C)N1[O]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 17.22 100
ethanol 17.22 100

Preparing Stock Solutions

The following data is based on the product molecular weight 172.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.81 mL 29.03 mL 58.06 mL
5 mM 1.16 mL 5.81 mL 11.61 mL
10 mM 0.58 mL 2.9 mL 5.81 mL
50 mM 0.12 mL 0.58 mL 1.16 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Francis and Sehgal (2006) The superoxide scavenger TEMPOL induces urokinase receptor (uPAR) expression in human prostate cancer cells. Mol.Cancer 5 21 PMID: 16756681

Deng-Bryant et al (2008) Neuroprotective effect of tempol, a catalytic scavenger of peroxynitrite-derived free radicals, in a mouse traumatic brain injury model. J.Cereb.Blood Flow Metab. 28 1114 PMID: 18319733

Khattab (2006) TEMPOL, a membrane-permeable radical scavenger, attenuates peroxynitrite- and superoxide anion-enhanced carrageenan-induced paw edema and hyperalgesia: a key role for superoxide anion. EurJ.Pharmacol. 548 167 PMID:

If you know of a relevant reference for Tempol, please let us know.

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Keywords: Tempol, supplier, Superoxide, scavenger, antioxidant, Antioxidants, Antioxidants, Tocris Bioscience

5 Citations for Tempol

Citations are publications that use Tocris products. Selected citations for Tempol include:

Ruparel et al (2012) Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation. J Biol Chem 153 2031 PMID: 22633978

Senturk et al (2014) p53ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state. Proc Natl Acad Sci U S A 111 E3287 PMID: 25074920

Nesuashvili et al (2013) Sensory nerve terminal mitochondrial dysfunction activates airway sensory nerves via transient receptor potential (TRP) channels. Mol Pharmacol 83 1007 PMID: 23444014

Valente et al (2012) Angiotensin II enhances AT1-Nox1 binding and stimulates arterial smooth muscle cell migration and proliferation through AT1, Nox1, and interleukin-18. Am J Physiol Heart Circ Physiol 303 H282 PMID: 22636674

Tomasovic et al (2015) Sestrin 2 Regulates PDGF Receptor β (PDGFRβ) Expression by Modulating Proteasomal and Nrf2 Transcription Factor Functions. Brain Res NULL PMID: 25716320

Do you know of a great paper that uses Tempol from Tocris? If so please let us know.

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