Tempol

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Cat.No. 3082 - Tempol | C9H18NO2 | CAS No. 2226-96-2
Description: Superoxide scavenger; antioxidant
Chemical Name: 1-Oxyl-2,2,6,6-tetramethyl-4-hydroxypiperidine
Purity: ≥99%
Datasheet
Citations (8)
Reviews (1)
Literature

Biological Activity

Superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects.

Technical Data

M. Wt 172.24
Formula C9H18NO2
Storage Store at -20°C
Purity ≥99%
CAS Number 2226-96-2
PubChem ID 137994
InChI Key UZFMOKQJFYMBGY-UHFFFAOYSA-N
Smiles CC1(C)CC(O)CC(C)(C)N1[O]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 17.22 100
ethanol 17.22 100

Preparing Stock Solutions

The following data is based on the product molecular weight 172.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.81 mL 29.03 mL 58.06 mL
5 mM 1.16 mL 5.81 mL 11.61 mL
10 mM 0.58 mL 2.9 mL 5.81 mL
50 mM 0.12 mL 0.58 mL 1.16 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Francis and Sehgal (2006) The superoxide scavenger TEMPOL induces urok. receptor (uPAR) expression in human prostate cancer cells. Mol.Cancer 5 21 PMID: 16756681

Deng-Bryant et al (2008) Neuroprotective effect of tempol, a catalytic scavenger of peroxynitrite-derived free radicals, in a mouse traumatic brain injury model. J.Cereb.Blood Flow Metab. 28 1114 PMID: 18319733

Khattab (2006) TEMPOL, a membrane-permeable radical scavenger, attenuates peroxynitrite- and superoxide anion-enhanced carrageenan-induced paw edema and hyperalgesia: a key role for superoxide anion. EurJ.Pharmacol. 548 167


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Keywords: Tempol, Tempol supplier, Superoxide, scavenger, antioxidant, Antioxidants, 3082, Tocris Bioscience

8 Citations for Tempol

Citations are publications that use Tocris products. Selected citations for Tempol include:

Tomasovic et al (2015) Sestrin 2 Regulates PDGF Receptor β (PDGFRβ) Expression by Modulating Proteasomal and Nrf2 Transcription Factor Functions. Brain Res NULL PMID: 25716320

Senturk et al (2014) p53ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state. Proc Natl Acad Sci U S A 111 E3287 PMID: 25074920

Hood et al (2016) Nicotinamide Adenine Dinucleotide Phosphate Oxidase-Mediated Redox Signaling and Vascular Remodeling by 16α-Hydroxyestrone in Human Pulmonary Artery Cells: Implications in Pulmonary Arterial Hypertension. Hypertension 68 796 PMID: 27402919

Ruparel et al (2012) Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation. J Biol Chem 153 2031 PMID: 22633978

Somanna et al (2016) The Nox1/4 Dual Inhibitor GKT137831 or Nox4 Knockdown Inhibits Angiotensin-II-Induced Adult Mouse Cardiac Fibroblast Proliferation and Migration. AT1 Physically Associates With Nox4. J Cell Physiol 231 1130 PMID: 26445208

Valente et al (2012) Angiotensin II enhances AT1-Nox1 binding and stimulates arterial smooth muscle cell migration and proliferation through AT1, Nox1, and interleukin-18. Am J Physiol Heart Circ Physiol 303 H282 PMID: 22636674

Beggs et al (2015) Trovafloxacin-induced replication stress sensitizes HepG2 cells to tumor necrosis factor-alpha-induced cytotoxicity mediated by extracellular signal-regulated kinase and ataxia telangiectasia and Rad3-related. Toxicology 331 35 PMID: 25748550

Nesuashvili et al (2013) Sensory nerve terminal mitochondrial dysfunction activates airway sensory nerves via transient receptor potential (TRP) channels. Mol Pharmacol 83 1007 PMID: 23444014


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Reviews for Tempol

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Tempol blunts 15d-PGJ2-induced ROS levels in HL-1 cardiomyocytes.
By Chintan Koyani on 10/13/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: HL-1 cardiomyocytes

HL-1 cardiomyocytes were incubated with Tempol (1 mM) for 30 min prior to 15d-PGJ2 treatments (15 μM) for 1 h to follow ROS generation using carboxy-H2DCFDA (10 μM). Figure shows that the antioxidant Tempol (a cell-permeable superoxide anion scavenger) blunted 15d-PGJ2-induced ROS formation efficiently.

PMID: 24698234
review image

Literature in this Area

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