Tegaserod maleate

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Cat.No. 4613 - Tegaserod maleate | C16H23N5O.C4H4O4 | CAS No. 189188-57-6
Description: 5-HT4 partial agonist
Chemical Name: 2-[(5-Methoxy-1H-indol-3-yl)methylene]-N-pentyl-hydrazinecarboximidamide maleate
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (4)

Biological Activity

Partial agonist of 5-HT4 (Ki = 12 nM).

Compound Libraries

Tegaserod maleate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 417.46
Formula C16H23N5O.C4H4O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 189188-57-6
PubChem ID 135413539
InChI Key CPDDZSSEAVLMRY-FEQFWAPWSA-N
Smiles O=C(/C=C\C(O)=O)O.CCCCCNC(N/N=C/C1=CNC2=C1C=C(OC)C=C2)=N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.75 100

Preparing Stock Solutions

The following data is based on the product molecular weight 417.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.4 mL 11.98 mL 23.95 mL
5 mM 0.48 mL 2.4 mL 4.79 mL
10 mM 0.24 mL 1.2 mL 2.4 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References

References are publications that support the biological activity of the product.

Buchheit et al (1995) The serotonin 5-HT4 receptor. 2. Structure-activity studies of the indole carbazimidamide class of agonists. J.Med.Chem. 38 2331 PMID: 7608899


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Keywords: Tegaserod maleate, Tegaserod maleate supplier, Tegaserod, maleate, partial, 5-HT4, agonists, serotonergics, Receptors, 4613, Tocris Bioscience

1 Citation for Tegaserod maleate

Citations are publications that use Tocris products. Selected citations for Tegaserod maleate include:

Beattie et al (2011) The Pharmacology of TD-8954, a Potent and Selective 5-HT(4) Receptor Agonist with Gastrointestinal Prokinetic Properties. Front Pharmacol 2 25 PMID: 21687517


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

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Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.