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Cat.No. 5482 - TDFA | Ac-Thr-Asp-[N5-(2-fluoro-1-iminoethyl)]-Orn-NH2 | CAS No. 1345019-64-8
Description: PAD4 inhibitor

Biological Activity

Protein arginine deiminase 4 (PAD4) inhibitor (IC50 values are 2.3, 8.5, 26 and 71 μM for PAD4, PAD1, PAD3 and PAD2, respectively).

Technical Data

M. Wt 448.45
Formula C17H29FN6O7
Sequence Ac-TD-X

(Modifications: Thr-1 = N-terminal Ac, X = N5-(2-fluoro-1-iminoethyl)]-Orn), X-3= C-terminal amide)

Storage Store at -20°C
CAS Number 1345019-64-8
PubChem ID 121513865
Smiles [H]N([C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(=N)CF)C(N)=O)C(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 448.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.23 mL 11.15 mL 22.3 mL
5 mM 0.45 mL 2.23 mL 4.46 mL
10 mM 0.22 mL 1.11 mL 2.23 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Jones et al (2012) Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors. ACS Chem.Biol. 7 160 PMID: 22004374

If you know of a relevant reference for TDFA, please let us know.

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Keywords: TDFA, supplier, PAD4, protein, arginine, deiminase, 4, inhibits, inhibitors, Post-translational, Modifications, Post-translational, Modifications, Tocris Bioscience

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