Discontinued Product

TDFA (Cat. No. 5482) has been withdrawn from sale for commercial reasons.
Description: PAD4 inhibitor

Biological Activity for TDFA

Protein arginine deiminase 4 (PAD4) inhibitor (IC50 values are 2.3, 8.5, 26 and 71 μM for PAD4, PAD1, PAD3 and PAD2, respectively).

Technical Data for TDFA

M. Wt 448.45
Formula C17H29FN6O7
Sequence Ac-TD-X

(Modifications: Thr-1 = N-terminal Ac, X = N5-(2-fluoro-1-iminoethyl)]-Orn), X-3= C-terminal amide)

Storage Store at -20°C
CAS Number 1345019-64-8
PubChem ID 121513865
Smiles [H]N([C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(=N)CF)C(N)=O)C(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for TDFA

References are publications that support the biological activity of the product.

Jones et al (2012) Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors. ACS Chem.Biol. 7 160 PMID: 22004374

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Keywords: TDFA, TDFA supplier, PAD4, protein, arginine, deiminase, 4, inhibits, inhibitors, Post-translational, Modifications, 5482, Tocris Bioscience

Citations for TDFA

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Currently there are no citations for TDFA.

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