TDFA

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Cat.No. 5482 - TDFA | Ac-Thr-Asp-[N5-(2-fluoro-1-iminoethyl)]-Orn-NH2 | CAS No. 1345019-64-8
Description: PAD4 inhibitor
Datasheet
Citations
Reviews
Literature

Biological Activity

Protein arginine deiminase 4 (PAD4) inhibitor (IC50 values are 2.3, 8.5, 26 and 71 μM for PAD4, PAD1, PAD3 and PAD2, respectively).

Technical Data

M. Wt 448.45
Formula C17H29FN6O7
Sequence Ac-TD-X

(Modifications: Thr-1 = N-terminal Ac, X = N5-(2-fluoro-1-iminoethyl)]-Orn), X-3= C-terminal amide)

Storage Store at -20°C
CAS Number 1345019-64-8
PubChem ID 121513865
InChI Key SOZMHIJABUOUSN-ORMVGFHCSA-N
Smiles [H]N([C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(=N)CF)C(N)=O)C(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 2 mg/ml in water

References

References are publications that support the biological activity of the product.

Jones et al (2012) Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors. ACS Chem.Biol. 7 160 PMID: 22004374


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Keywords: TDFA, TDFA supplier, PAD4, protein, arginine, deiminase, 4, inhibits, inhibitors, Post-translational, Modifications, 5482, Tocris Bioscience

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Literature in this Area

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