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TCS PrP Inhibitor 13
Antiprion agent. Potently inhibits protease-resistant prion protein (PrP-res) accumulation in two types of prion-infected mouse neuroblastoma (N2a) cell lines (IC50 = 3 nM). Also reduces PrP expression and decreases proliferation and survival in schwannoma cell lines.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 281.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.56 mL||17.78 mL||35.55 mL|
|5 mM||0.71 mL||3.56 mL||7.11 mL|
|10 mM||0.36 mL||1.78 mL||3.56 mL|
|50 mM||0.07 mL||0.36 mL||0.71 mL|
References are publications that support the biological activity of the product.
Kimata et al (2007) New series of antiprion compounds: pyrazolone derivatives have potent activity of inhibiting protease-resistant prion protein accumulation. J.Med.Chem. 50 5053 PMID: 17850126
Provenzano et al (2017) Cellular prion protein (PrPC) in the development of Merlin-deficient tumours. Oncogene. 36 6132 PMID: 28692055
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1 Citation for TCS PrP Inhibitor 13
Citations are publications that use Tocris products. Selected citations for TCS PrP Inhibitor 13 include:
Provenzano et al (2017) Cellular prion protein (PrPC) in the development of Merlin-deficient tumours. Oncogene. PMID: 28692055
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