TCS PrP Inhibitor 13

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Cat.No. 3238 - TCS PrP Inhibitor 13 | C15H11N3O3 | CAS No. 34320-83-7
Description: Antiprion agent; inhibits PrPSc accumulation
Chemical Name: 2,4-Dihydro-5-(4-nitrophenyl)-2-phenyl-3H-pyrazol-3-one
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature
Pathways

Biological Activity

Antiprion agent. Potently inhibits protease-resistant prion protein (PrP-res) accumulation in two types of prion-infected mouse neuroblastoma (N2a) cell lines (IC50 = 3 nM). Also reduces PrP expression and decreases proliferation and survival in schwannoma cell lines.

Technical Data

M. Wt 281.27
Formula C15H11N3O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 34320-83-7
PubChem ID 2750328
InChI Key FDAVFKZPGQEGDX-UHFFFAOYSA-N
Smiles O=C(C2)N(C3=CC=CC=C3)N=C2C1=CC=C([N+]([O-])=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.13 100
ethanol 7.03 25

Preparing Stock Solutions

The following data is based on the product molecular weight 281.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.56 mL 17.78 mL 35.55 mL
5 mM 0.71 mL 3.56 mL 7.11 mL
10 mM 0.36 mL 1.78 mL 3.56 mL
50 mM 0.07 mL 0.36 mL 0.71 mL

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References

References are publications that support the biological activity of the product.

Kimata et al (2007) New series of antiprion compounds: pyrazolone derivatives have potent activity of inhibiting protease-resistant prion protein accumulation. J.Med.Chem. 50 5053 PMID: 17850126

Provenzano et al (2017) Cellular prion protein (PrPC) in the development of Merlin-deficient tumours. Oncogene. 36 6132 PMID: 28692055


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1 Citation for TCS PrP Inhibitor 13

Citations are publications that use Tocris products. Selected citations for TCS PrP Inhibitor 13 include:

Provenzano et al (2017) Cellular prion protein (PrPC) in the development of Merlin-deficient tumours. Oncogene. PMID: 28692055


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Literature in this Area

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Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease

Pathways for TCS PrP Inhibitor 13

MAPK

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.