Potent and selective checkpoint kinase 1 (chk1) inhibitor (Ki = 0.38 nM, EC50 = 60 nM). Enhances the cell killing activity of Gemcitabine (Cat. No. 3259) in breast and prostate cancer cell lines and displays antiproliferative effects in vitro.
|Storage||Store at -80°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 412.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.42 mL||12.12 mL||24.24 mL|
|5 mM||0.48 mL||2.42 mL||4.85 mL|
|10 mM||0.24 mL||1.21 mL||2.42 mL|
|50 mM||0.05 mL||0.24 mL||0.48 mL|
References are publications that support the products' biological activity.
Teng et al (2007) Structure-based design of (5-arylamino-2H-pyrazol-3-yl)-biphenyl-2',4'-diols as novel and potent human CHK1 inhibitors. J.Med.Chem. 50 5253 PMID: 17887663
If you know of a relevant reference for TCS 2312, please let us know.
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Keywords: TCS 2312, supplier, Potent, Chk1, inhibitors, inhibits, Checkpoint, Kinases, Control, TCS2312, Checkpoint, Kinases, Checkpoint, Control, Kinases, Checkpoint, Kinases, Tocris Bioscience
2 Citations for TCS 2312
Citations are publications that use Tocris products. Selected citations for TCS 2312 include:
Davari et al (2014) Checkpoint kinase 2 is required for efficient immunoglobulin diversification. Cell Cycle 13 3659 PMID: 25483076
Frankenberger et al (2014) Checkpoint kinase 1 negatively regulates somatic hypermutation. Nucleic Acids Res 42 3666 PMID: 24423870
Do you know of a great paper that uses TCS 2312 from Tocris? If so please let us know.
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Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.