TCS 2312

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Cat.No. 3038 - TCS 2312 | C25H24N4O2 | CAS No. 838823-31-7
Description: Potent Chk1 inhibitor
Chemical Name: 4'-[5-[[3-[(Cyclopropylamino)methyl]phenyl]amino]-1H-pyrazol-3-yl]-[1,1'-biphenyl]-2,4-diol
Purity: ≥97% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (3)

Biological Activity

Potent and selective checkpoint kinase 1 (chk1) inhibitor (Ki = 0.38 nM, EC50 = 60 nM). Enhances the cell killing activity of Gemcitabine (Cat. No. 3259) in breast and prostate cancer cell lines and displays antiproliferative effects in vitro.

Technical Data

M. Wt 412.48
Formula C25H24N4O2
Storage Store at -80°C
Purity ≥97% (HPLC)
CAS Number 838823-31-7
PubChem ID 11258443
InChI Key BYFCMDWKTJJQGR-UHFFFAOYSA-N
Smiles OC1=CC(O)=CC=C1C2=CC=C(C3=CC(NC4=CC=C(CNC5CC5)C=C4)=NN3)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.25 20

Preparing Stock Solutions

The following data is based on the product molecular weight 412.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 12.12 mL 60.61 mL 121.22 mL
1 mM 2.42 mL 12.12 mL 24.24 mL
2 mM 1.21 mL 6.06 mL 12.12 mL
10 mM 0.24 mL 1.21 mL 2.42 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Teng et al (2007) Structure-based design of (5-arylamino-2H-pyrazol-3-yl)-biphenyl-2',4'-diols as novel and potent human CHK1 inhibitors. J.Med.Chem. 50 5253 PMID: 17887663


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View all Checkpoint Kinase Inhibitors

Keywords: TCS 2312, TCS 2312 supplier, Potent, Chk1, inhibitors, inhibits, Checkpoint, Kinases, Control, TCS2312, 3038, Tocris Bioscience

2 Citations for TCS 2312

Citations are publications that use Tocris products. Selected citations for TCS 2312 include:

Davari et al (2014) Checkpoint kinase 2 is required for efficient immunoglobulin diversification. Cell Cycle 13 3659 PMID: 25483076

Frankenberger et al (2014) Checkpoint kinase 1 negatively regulates somatic hypermutation. Nucleic Acids Res 42 3666 PMID: 24423870


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

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Cell Cycle & DNA Damage Repair

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.