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TCS 2312

Cat. No. 3038 2 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent Chk1 inhibitor
Chemical Name: 4'-[5-[[3-[(Cyclopropylamino)methyl]phenyl]amino]-1H-pyrazol-3-yl]-[1,1'-biphenyl]-2,4-diol
Purity: ≥97% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (3)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for TCS 2312

TCS 2312 is a potent and selective checkpoint kinase 1 (chk1) inhibitor (Ki = 0.38 nM, EC50 = 60 nM). Enhances the cell killing activity of Gemcitabine (Cat. No. 3259) in breast and prostate cancer cell lines and displays antiproliferative effects in vitro.

Technical Data for TCS 2312

M. Wt 412.48
Formula C25H24N4O2
Storage Store at -80°C
Purity ≥97% (HPLC)
CAS Number 838823-31-7
PubChem ID 11258443
InChI Key BYFCMDWKTJJQGR-UHFFFAOYSA-N
Smiles OC1=CC(O)=CC=C1C2=CC=C(C3=CC(NC4=CC=C(CNC5CC5)C=C4)=NN3)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TCS 2312

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.25 20

Preparing Stock Solutions for TCS 2312

The following data is based on the product molecular weight 412.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 12.12 mL 60.61 mL 121.22 mL
1 mM 2.42 mL 12.12 mL 24.24 mL
2 mM 1.21 mL 6.06 mL 12.12 mL
10 mM 0.24 mL 1.21 mL 2.42 mL

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Product Datasheets for TCS 2312

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for TCS 2312

References are publications that support the biological activity of the product.

Teng et al (2007) Structure-based design of (5-arylamino-2H-pyrazol-3-yl)-biphenyl-2',4'-diols as novel and potent human CHK1 inhibitors. J.Med.Chem. 50 5253 PMID: 17887663

If you know of a relevant reference for TCS 2312, please let us know.

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Keywords: TCS 2312, TCS 2312 supplier, Potent, Chk1, inhibitors, inhibits, Checkpoint, Kinases, Control, TCS2312, 3038, Tocris Bioscience

2 Citations for TCS 2312

Citations are publications that use Tocris products. Selected citations for TCS 2312 include:

Davari et al (2014) Checkpoint kinase 2 is required for efficient immunoglobulin diversification. Cell Cycle 13 3659 PMID: 25483076

Frankenberger et al (2014) Checkpoint kinase 1 negatively regulates somatic hypermutation. Nucleic Acids Res 42 3666 PMID: 24423870

Do you know of a great paper that uses TCS 2312 from Tocris? Please let us know.

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Literature in this Area

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