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Biological Activity for TCS 2312
TCS 2312 is a potent and selective checkpoint kinase 1 (chk1) inhibitor (Ki = 0.38 nM, EC50 = 60 nM). Enhances the cell killing activity of Gemcitabine (Cat. No. 3259) in breast and prostate cancer cell lines and displays antiproliferative effects in vitro.
Technical Data for TCS 2312
|Storage||Store at -80°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TCS 2312
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for TCS 2312
The following data is based on the product molecular weight 412.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||12.12 mL||60.61 mL||121.22 mL|
|1 mM||2.42 mL||12.12 mL||24.24 mL|
|2 mM||1.21 mL||6.06 mL||12.12 mL|
|10 mM||0.24 mL||1.21 mL||2.42 mL|
References for TCS 2312
References are publications that support the biological activity of the product.
Teng et al (2007) Structure-based design of (5-arylamino-2H-pyrazol-3-yl)-biphenyl-2',4'-diols as novel and potent human CHK1 inhibitors. J.Med.Chem. 50 5253 PMID: 17887663
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Keywords: TCS 2312, TCS 2312 supplier, Potent, Chk1, inhibitors, inhibits, Checkpoint, Kinases, Control, TCS2312, 3038, Tocris Bioscience
2 Citations for TCS 2312
Citations are publications that use Tocris products. Selected citations for TCS 2312 include:
Davari et al (2014) Checkpoint kinase 2 is required for efficient immunoglobulin diversification. Cell Cycle 13 3659 PMID: 25483076
Frankenberger et al (2014) Checkpoint kinase 1 negatively regulates somatic hypermutation. Nucleic Acids Res 42 3666 PMID: 24423870
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Literature in this Area
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Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.