TC-S 7004

Pricing Availability   Qty
Description: Potent and selective DYRK1A/B inhibitor
Chemical Name: N-[2-Chloro-5-[[[(3-chlorophenyl)methyl]amino]carbonyl]phenyl]-7,8-dihydro-2-methoxy-7-oxopyrido[2,3-d]pyrimidine-6-carboxamide
Purity: ≥98% (HPLC)
Citations (1)
Literature (2)

Biological Activity for TC-S 7004

TC-S 7004 is a potent and selective DYRK1A/B inhibitor (IC50 values are 22 and 68 nM respectively). Selective for DYRK1A/B over a panel of other kinases. Reduces accumulation of quiescent Panc1 pancreatic cancer cells in G0 under serum free conditions. Also induces DNA damage and apoptosis in quiescent Panc1 cells.

Compound Libraries for TC-S 7004

TC-S 7004 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for TC-S 7004

M. Wt 498.32
Formula C23H17Cl2N5O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1386979-55-0
PubChem ID 57523919
Smiles O=C(NC3=CC(C(NCC4=CC(Cl)=CC=C4)=O)=CC=C3Cl)C2=CC1=CN=C(OC)N=C1NC2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TC-S 7004

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 49.83 100

Preparing Stock Solutions for TC-S 7004

The following data is based on the product molecular weight 498.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.01 mL 10.03 mL 20.07 mL
5 mM 0.4 mL 2.01 mL 4.01 mL
10 mM 0.2 mL 1 mL 2.01 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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References for TC-S 7004

References are publications that support the biological activity of the product.

Ewton et al (2011) Inactivation of mirk/dyrk1b kinase targets quiescent pancreatic cancer cells. Mol.Cancer Ther. 10 2104 PMID: 21878655

Anderson et al (2013) Pyrido[2,3-d]pyrimidines: discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors. Bioorg.Med.Chem.Lett. 15 6610 PMID: 24239188

If you know of a relevant reference for TC-S 7004, please let us know.

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Keywords: TC-S 7004, TC-S 7004 supplier, TC-S7004, Mirk, DYRK1B, DYRK1A, potent, inhibitors, inhibits, DYRK, 5088, Tocris Bioscience

1 Citation for TC-S 7004

Citations are publications that use Tocris products. Selected citations for TC-S 7004 include:

Blake et al (2019) Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancer. Sci Signal 12 PMID: 31311847

Do you know of a great paper that uses TC-S 7004 from Tocris? Please let us know.

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Literature in this Area

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