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Submit ReviewTC-P 262
Discontinued Product
TC-P 262 (Cat. No. 4386) has been withdrawn from sale for commercial reasons.
Description: Selective P2X3 and P2X2/3 antagonist
Chemical Name: 5-[5-Methyl-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine
Purity: ≥99% (HPLC)
Biological Activity for TC-P 262
TC-P 262 is a selective P2X3 and P2X2/3 receptor antagonist (pIC50 values are 7.39 and 6.68 respectively). Displays no detectable activity at P2X1, P2X2, P2X4 and P2X7 receptors (pIC50 < 4.7).
Technical Data for TC-P 262
| M. Wt | 258.32 |
| Formula | C14H18N4O |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 873398-67-5 |
| PubChem ID | 59598765 |
| InChI Key | RAKSAPLZNJXYRB-UHFFFAOYSA-N |
| Smiles | NC1=NC(N)=NC=C1OC2=C(C(C)C)C=CC(C)=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TC-P 262
References for TC-P 262
References are publications that support the biological activity of the product.
Ballini et al (2011) Characterization of three diaminopyrimidines as potent and selective antagonists of P2X3 and P2X2/3 receptors with in vivo efficacy in a pain model. Br.J.Pharmacol. 163 1315 PMID: 21410458
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Keywords: TC-P 262, TC-P 262 supplier, Selective, P2X3, P2X2/3, receptors, antagonists, TC-P262, P2X, Receptors, 4386, Tocris Bioscience
Citations for TC-P 262
Citations are publications that use Tocris products.
Currently there are no citations for TC-P 262.
Reviews for TC-P 262
Average Rating: 4 (Based on 1 Review.)
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Itch behavior.
By
jialie luo on 01/10/2018
Assay Type: In Vivo
Species: Mouse
TC-P 262 was used to test itch response
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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