You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for TC-P 262
TC-P 262 is a selective P2X3 and P2X2/3 receptor antagonist (pIC50 values are 7.39 and 6.68 respectively). Displays no detectable activity at P2X1, P2X2, P2X4 and P2X7 receptors (pIC50 < 4.7).
Technical Data for TC-P 262
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TC-P 262
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for TC-P 262
The following data is based on the product molecular weight 258.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.87 mL||19.36 mL||38.71 mL|
|5 mM||0.77 mL||3.87 mL||7.74 mL|
|10 mM||0.39 mL||1.94 mL||3.87 mL|
|50 mM||0.08 mL||0.39 mL||0.77 mL|
References for TC-P 262
References are publications that support the biological activity of the product.
Ballini et al (2011) Characterization of three diaminopyrimidines as potent and selective antagonists of P2X3 and P2X2/3 receptors with in vivo efficacy in a pain model. Br.J.Pharmacol. 163 1315 PMID: 21410458
If you know of a relevant reference for TC-P 262, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: TC-P 262, TC-P 262 supplier, Selective, P2X3, P2X2/3, receptors, antagonists, TC-P262, P2X, Receptors, 4386, Tocris Bioscience
Citations for TC-P 262
Citations are publications that use Tocris products.
Currently there are no citations for TC-P 262. Do you know of a great paper that uses TC-P 262 from Tocris? Please let us know.
Reviews for TC-P 262
Average Rating: 4 (Based on 1 Review.)
Have you used TC-P 262?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.