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Submit ReviewTC-P 262
Description: Selective P2X3, P2X2/3 antagonist
Chemical Name: 5-[5-Methyl-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine
Purity: ≥99% (HPLC)
Biological Activity
Selective P2X3 and P2X2/3 receptor antagonist (pIC50 values are 7.39 and 6.68 respectively). Displays no detectable activity at P2X1, P2X2, P2X4 and P2X7 receptors (pIC50 < 4.7).
Technical Data
| M. Wt | 258.32 |
| Formula | C14H18N4O |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 873398-67-5 |
| PubChem ID | 59598765 |
| InChI Key | RAKSAPLZNJXYRB-UHFFFAOYSA-N |
| Smiles | NC1=NC(N)=NC=C1OC2=C(C(C)C)C=CC(C)=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.83 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 258.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.87 mL | 19.36 mL | 38.71 mL |
| 5 mM | 0.77 mL | 3.87 mL | 7.74 mL |
| 10 mM | 0.39 mL | 1.94 mL | 3.87 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.77 mL |
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References
References are publications that support the biological activity of the product.
Ballini et al (2011) Characterization of three diaminopyrimidines as potent and selective antagonists of P2X3 and P2X2/3 receptors with in vivo efficacy in a pain model. Br.J.Pharmacol. 163 1315 PMID: 21410458
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Keywords: TC-P 262, TC-P 262 supplier, Selective, P2X3, P2X2/3, receptors, antagonists, TC-P262, P2X, Receptors, 4386, Tocris Bioscience
Citations for TC-P 262
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Reviews for TC-P 262
Average Rating: 4 (Based on 1 Review.)
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Itch behavior.
By
jialie luo on 01/10/2018
Assay Type: In Vivo
Species: Mouse
TC-P 262 was used to test itch response
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