TC-P 262

Discontinued Product

TC-P 262 (Cat. No. 4386) has been withdrawn from sale for commercial reasons.
Description: Selective P2X3 and P2X2/3 antagonist
Chemical Name: 5-[5-Methyl-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews (1)
Literature (1)

Biological Activity for TC-P 262

TC-P 262 is a selective P2X3 and P2X2/3 receptor antagonist (pIC50 values are 7.39 and 6.68 respectively). Displays no detectable activity at P2X1, P2X2, P2X4 and P2X7 receptors (pIC50 < 4.7).

Technical Data for TC-P 262

M. Wt 258.32
Formula C14H18N4O
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 873398-67-5
PubChem ID 59598765
InChI Key RAKSAPLZNJXYRB-UHFFFAOYSA-N
Smiles NC1=NC(N)=NC=C1OC2=C(C(C)C)C=CC(C)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for TC-P 262

References are publications that support the biological activity of the product.

Ballini et al (2011) Characterization of three diaminopyrimidines as potent and selective antagonists of P2X3 and P2X2/3 receptors with in vivo efficacy in a pain model. Br.J.Pharmacol. 163 1315 PMID: 21410458

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Keywords: TC-P 262, TC-P 262 supplier, Selective, P2X3, P2X2/3, receptors, antagonists, TC-P262, P2X, Receptors, 4386, Tocris Bioscience

1 Citation for TC-P 262

Citations are publications that use Tocris products. Selected citations for TC-P 262 include:

Hui et al (2020) Simultaneous Control of Endogenous and User-Defined Genetic Pathways Using Unique ecDHFR Pharmacological Chaperones. Cell Chem Biol 27 622-634.e6 PMID: 32330442


Reviews for TC-P 262

Average Rating: 4 (Based on 1 Review.)

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Itch behavior.
By jialie luo on 01/10/2018
Assay Type: In Vivo
Species: Mouse

TC-P 262 was used to test itch response

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


P2X and P2Y Receptors Scientific Review

P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.