TC-P 262

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Cat.No. 4386 - TC-P 262 | C14H18N4O | CAS No. 873398-67-5
Description: Selective P2X3, P2X2/3 antagonist
Chemical Name: 5-[5-Methyl-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews (1)
Literature

Biological Activity

Selective P2X3 and P2X2/3 receptor antagonist (pIC50 values are 7.39 and 6.68 respectively). Displays no detectable activity at P2X1, P2X2, P2X4 and P2X7 receptors (pIC50 < 4.7).

Technical Data

M. Wt 258.32
Formula C14H18N4O
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 873398-67-5
PubChem ID 59598765
InChI Key RAKSAPLZNJXYRB-UHFFFAOYSA-N
Smiles NC1=NC(N)=NC=C1OC2=C(C(C)C)C=CC(C)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.83 100

Preparing Stock Solutions

The following data is based on the product molecular weight 258.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.87 mL 19.36 mL 38.71 mL
5 mM 0.77 mL 3.87 mL 7.74 mL
10 mM 0.39 mL 1.94 mL 3.87 mL
50 mM 0.08 mL 0.39 mL 0.77 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Ballini et al (2011) Characterization of three diaminopyrimidines as potent and selective antagonists of P2X3 and P2X2/3 receptors with in vivo efficacy in a pain model. Br.J.Pharmacol. 163 1315 PMID: 21410458


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Keywords: TC-P 262, TC-P 262 supplier, Selective, P2X3, P2X2/3, receptors, antagonists, TC-P262, P2X, Receptors, 4386, Tocris Bioscience

Citations for TC-P 262

Citations are publications that use Tocris products.

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Reviews for TC-P 262

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Itch behavior
By jialie luo on 01/10/2018
Assay Type: In Vivo
Species: Mouse

TC-P 262 was used to test itch response

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Literature in this Area

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