Discontinued Product

TC KHNS 11 (Cat. No. 6079) has been withdrawn from sale for commercial reasons.
Description: Potent and selective PI 3-kinase δ inhibitor; orally bioavailable
Chemical Name: 5-[4-[3-[(4-Acetyl-1-piperazinyl)carbonyl]phenyl]-6-quinazolinyl]-2-methoxy-3-pyridinecarbonitrile
Purity: ≥98% (HPLC)

Biological Activity for TC KHNS 11

TC KHNS 11 is a potent and selective PI 3-kinase δ inhibitor (biochemical IC50 values are 9, 262, 1650 and 4630 nM for PI 3-Kδ, PI 3-Kα, PI 3-Kβ and PI 3-Kγ, respectively; cellular IC50 values are 49, 3440 and 6530 nM for PI 3-Kδ, PI 3-Kα and PI 3-Kβ, respectively). Selective for PI 3-Kδ over a panel of lipid and protein kinases. Inhibits B-cell function. Exhibits moderate oral bioavailability in vivo.

Technical Data for TC KHNS 11

M. Wt 492.53
Formula C28H24N6O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1431540-99-6
PubChem ID 86732669
Smiles O=C(N1CCN(C(C)=O)CC1)C2=CC=CC(C3=NC=NC(C=C4)=C3C=C4C(C=C5C#N)=CN=C5OC)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for TC KHNS 11

References are publications that support the biological activity of the product.

Hoegenauer et al (2016) Discovery and pharmacological characterization of novel quinazoline-based PI3K delta-selective inhibitors. ACS Med.Chem.Lett. 7 762 PMID: 27563400

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Keywords: TC KHNS 11, TC KHNS 11 supplier, TCKHNS11, PI, 3-kinase, pi3k, pi3kd, pi3kdelta, pi3kδ, pi3kgamma, pi3kg, pi3kγ, pi3kalpha, pi3ka, pi3kα, pi3kbeta, pi3kb, pi3kβ, inhibitors, inhibits, 3-Kinase, 6079, Tocris Bioscience

Citations for TC KHNS 11

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Currently there are no citations for TC KHNS 11.

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