Pricing Availability   Qty
Description: Potent and selective PI 3-kinase δ inhibitor; orally bioavailable
Chemical Name: 5-[4-[3-[(4-Acetyl-1-piperazinyl)carbonyl]phenyl]-6-quinazolinyl]-2-methoxy-3-pyridinecarbonitrile
Purity: ≥98% (HPLC)
Literature (4)

Biological Activity for TC KHNS 11

TC KHNS 11 is a potent and selective PI 3-kinase δ inhibitor (biochemical IC50 values are 9, 262, 1650 and 4630 nM for PI 3-Kδ, PI 3-Kα, PI 3-Kβ and PI 3-Kγ, respectively; cellular IC50 values are 49, 3440 and 6530 nM for PI 3-Kδ, PI 3-Kα and PI 3-Kβ, respectively). Selective for PI 3-Kδ over a panel of lipid and protein kinases. Inhibits B-cell function. Exhibits moderate oral bioavailability in vivo.

Technical Data for TC KHNS 11

M. Wt 492.53
Formula C28H24N6O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1431540-99-6
PubChem ID 86732669
Smiles O=C(N1CCN(C(C)=O)CC1)C2=CC=CC(C3=NC=NC(C=C4)=C3C=C4C(C=C5C#N)=CN=C5OC)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TC KHNS 11

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 49.25 100

Preparing Stock Solutions for TC KHNS 11

The following data is based on the product molecular weight 492.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.03 mL 10.15 mL 20.3 mL
5 mM 0.41 mL 2.03 mL 4.06 mL
10 mM 0.2 mL 1.02 mL 2.03 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

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References for TC KHNS 11

References are publications that support the biological activity of the product.

Hoegenauer et al (2016) Discovery and pharmacological characterization of novel quinazoline-based PI3K delta-selective inhibitors. ACS Med.Chem.Lett. 7 762 PMID: 27563400

If you know of a relevant reference for TC KHNS 11, please let us know.

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Keywords: TC KHNS 11, TC KHNS 11 supplier, TCKHNS11, PI, 3-kinase, pi3k, pi3kd, pi3kdelta, pi3kδ, pi3kgamma, pi3kg, pi3kγ, pi3kalpha, pi3ka, pi3kα, pi3kbeta, pi3kb, pi3kβ, inhibitors, inhibits, 3-Kinase, 6079, Tocris Bioscience

Citations for TC KHNS 11

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