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TC KHNS 11 is a potent and selective PI 3-kinase δ inhibitor (biochemical IC50 values are 9, 262, 1650 and 4630 nM for PI 3-Kδ, PI 3-Kα, PI 3-Kβ and PI 3-Kγ, respectively; cellular IC50 values are 49, 3440 and 6530 nM for PI 3-Kδ, PI 3-Kα and PI 3-Kβ, respectively). Selective for PI 3-Kδ over a panel of lipid and protein kinases. Inhibits B-cell function. Exhibits moderate oral bioavailability in vivo.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 492.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.03 mL||10.15 mL||20.3 mL|
|5 mM||0.41 mL||2.03 mL||4.06 mL|
|10 mM||0.2 mL||1.02 mL||2.03 mL|
|50 mM||0.04 mL||0.2 mL||0.41 mL|
References are publications that support the biological activity of the product.
Hoegenauer et al (2016) Discovery and pharmacological characterization of novel quinazoline-based PI3K delta-selective inhibitors. ACS Med.Chem.Lett. 7 762 PMID: 27563400
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Keywords: TC KHNS 11, TC KHNS 11 supplier, TCKHNS11, PI, 3-kinase, pi3k, pi3kd, pi3kdelta, pi3kδ, pi3kgamma, pi3kg, pi3kγ, pi3kalpha, pi3ka, pi3kα, pi3kbeta, pi3kb, pi3kβ, inhibitors, inhibits, 3-Kinase, 6079, Tocris Bioscience
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