TC-H 106

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Cat.No. 4270 - TC-H 106 | C20H25N3O2 | CAS No. 937039-45-7
Description: Class I histone deacetylase inhibitor
Chemical Name: N1-(2-Aminophenyl)-N7-(4-methylphenyl)heptanediamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Class I histone deacetylase (HDAC) inhibitor (IC50 values are 150, 370, 760 and 5000 nM for HDAC1, HDAC3, HDAC2 and HDAC8 respectively). Exhibits slow, tight-binding inhibitory activity. Displays no activity against class II HDACs. Brain penetrant.

Compound Libraries

TC-H 106 is also offered as part of the Tocriscreen Plus and Tocriscreen Epigenetics Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 339.43
Formula C20H25N3O2
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 937039-45-7
PubChem ID 16070100
InChI Key WTKBRPXPNAKVEQ-UHFFFAOYSA-N
Smiles NC1=CC=CC=C1NC(CCCCCC(NC2=CC=C(C)C=C2)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.94 100
ethanol 16.97 50

Preparing Stock Solutions

The following data is based on the product molecular weight 339.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.95 mL 14.73 mL 29.46 mL
5 mM 0.59 mL 2.95 mL 5.89 mL
10 mM 0.29 mL 1.47 mL 2.95 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Chou et al (2008) Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases. J.Biol.Chem. 283 35402 PMID: 18953021

Rai et al (2008) HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model. PLoS ONE 3 e1958 PMID: 18463734

Xu et al (2009) Chemical probes identify a role for histone deacetylase 3 in Friedrich's ataxia gene silencing. Chem.Biol. 16 980 PMID: 19778726


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Keywords: TC-H 106, supplier, TC-H106, histones, deacetylases, hdacs, inhibitiors, class, I, HDAC3, HDAC1, epigenetics, Histone, Deacetylases, Histone, Deacetylases, Tocris Bioscience

Citations for TC-H 106

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Literature in this Area

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Epigenetics

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Epigenetics

Epigenetics Research Bulletin

Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:

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  • DNA Methyltransferases
  • Histone Deacetylases
  • Histone Demethylases
  • Histone Methyltransferases
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Pathways for TC-H 106

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