TC-H 106

Pricing Availability Delivery Time Qty
Cat.No. 4270 - TC-H 106 | C20H25N3O2 | CAS No. 937039-45-7
Description: Class I histone deacetylase inhibitor
Chemical Name: N1-(2-Aminophenyl)-N7-(4-methylphenyl)heptanediamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Class I histone deacetylase (HDAC) inhibitor (IC50 values are 150, 370, 760 and 5000 nM for HDAC1, HDAC3, HDAC2 and HDAC8 respectively). Exhibits slow, tight-binding inhibitory activity. Displays no activity against class II HDACs. Brain penetrant.

Compound Libraries

TC-H 106 is also offered as part of the Tocriscreen Plus and Tocriscreen Epigenetics Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 339.43
Formula C20H25N3O2
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 937039-45-7
PubChem ID 16070100
InChI Key WTKBRPXPNAKVEQ-UHFFFAOYSA-N
Smiles NC1=CC=CC=C1NC(CCCCCC(NC2=CC=C(C)C=C2)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.94 100
ethanol 16.97 50

Preparing Stock Solutions

The following data is based on the product molecular weight 339.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.95 mL 14.73 mL 29.46 mL
5 mM 0.59 mL 2.95 mL 5.89 mL
10 mM 0.29 mL 1.47 mL 2.95 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Chou et al (2008) Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases. J.Biol.Chem. 283 35402 PMID: 18953021

Rai et al (2008) HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model. PLoS ONE 3 e1958 PMID: 18463734

Xu et al (2009) Chemical probes identify a role for histone deacetylase 3 in Friedrich's ataxia gene silencing. Chem.Biol. 16 980 PMID: 19778726


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Keywords: TC-H 106, TC-H 106 supplier, TC-H106, histones, deacetylases, hdacs, inhibitiors, class, I, HDAC3, HDAC1, epigenetics, Class, HDACs, 4270, Tocris Bioscience

Citations for TC-H 106

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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