TC-G 1000

Discontinued Product

TC-G 1000 (Cat. No. 5021) has been withdrawn from sale for commercial reasons.
Description: Potent and selective α2D agonist
Chemical Name: 4-(6,7-Dihydro-1,3-dimethylbenzo[c]thien-4-yl)-1H-imidazole maleate
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for TC-G 1000

TC-G 1000 is a potent and selective α2D-adrenoceptor agonist (Ki values are 8.6 pM and 110 nM for rat α2D and α1 receptors respectively and 25, 26 and 100 nM for human α2A, α2C and α2B receptors respectively. Exhibits analgesic activity in a mouse model of abdominal irritation. Orally active.

Technical Data for TC-G 1000

M. Wt 346.4
Formula C13H14N2S.C4H4O4
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 245744-18-7
PubChem ID 90488997
Smiles CC1=C2C(C(C3=CNC=N3)=CCC2)=C(C)S1.O=C(\C=C/C(O)=O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for TC-G 1000

References are publications that support the biological activity of the product.

Ross et al (2000) α2 adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4-(4-Imidazo)-1,3-dimethyl-6,7-dihydrothianaphthene as a high-affinity ligand for the α2D adrenergic receptor. J.Med.Chem. 43 1423 PMID: 10715142

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Keywords: TC-G 1000, TC-G 1000 supplier, TC-G1000, potent, selective, adrenergic, receptors, agonists, alpha2d, alpha1, alpha2a, alpha2b, alpha2c, α2d, α2a, α1, α2b, α2c, adrenoceptors, Adrenergic, Alpha-2, Receptors, 5021, Tocris Bioscience

Citations for TC-G 1000

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Currently there are no citations for TC-G 1000.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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