TC E3 5032

Discontinued Product

TC E3 5032 (Cat. No. 6628) has been withdrawn from sale for commercial reasons.
Description: Precursor to Pomalidomide-based PROTACs
Chemical Name: 2-(2,6-Dioxo-3-piperidinyl)-4-fluoro-1H-isoindole-1,3(2H)-dione
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for TC E3 5032

TC E3 5032 is a functionalized cereblon ligand for PROTAC® research and development. Precursor to Pomalidomide (Cat.No. 6302) -based PROTACs. Incorporates a fluoro leaving group to allow conjugation to amine linker. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines for TC E3 5032

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for TC E3 5032

M. Wt 276.22
Formula C13H9FN2O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 835616-60-9
PubChem ID 11859051
Smiles O=C(C1=C(C=CC=C1C2=O)F)N2C3CCC(NC3=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for TC E3 5032

References are publications that support the biological activity of the product.

Remillard et al (2017) Degradation of the BAF complex factor BRD9 by heterobifunctional ligands. Angew.Chem.Int.Ed.Engl. 56 5738 PMID: 28418626

Keywords: TC E3 5032, TC E3 5032 supplier, TCE35032, Proteolysis, Targeting, Chimera, PROTAC, cereblon, E3, ubiquitin, ligase, CRBN, 911109-85-8, 2243823-26-7, Functionalized, Ligase, Ligands, 6628, Tocris Bioscience

Citations for TC E3 5032

Citations are publications that use Tocris products.

Currently there are no citations for TC E3 5032.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia