TC E3 5032

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Cat.No. 6628 - TC E3 5032 | C13H9FN2O4 | CAS No. 835616-60-9
Description: Precursor to Pomalidomide-based PROTACs
Chemical Name: 2-(2,6-Dioxo-3-piperidinyl)-4-fluoro-1H-isoindole-1,3(2H)-dione
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Functionalized cereblon ligand for PROTAC® research and development. Precursor to Pomalidomide (Cat.No. 6302) -based PROTACs. Incorporates a fluoro leaving group to allow conjugation to amine linker. Part of a range of functionalized tool molecules for PROTAC R&D.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage guidelines:

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data

M. Wt 276.22
Formula C13H9FN2O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 835616-60-9
PubChem ID 11859051
InChI Key CRAUTELYXAAAPW-UHFFFAOYSA-N
Smiles O=C(C1=C(C=CC=C1C2=O)F)N2C3CCC(NC3=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Remillard et al (2017) Degradation of the BAF complex factor BRD9 by heterobifunctional ligands. Angew.Chem.Int.Ed.Engl. 56 5738 PMID: 28418626


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Keywords: TC E3 5032, TC E3 5032 supplier, TCE35032, Proteolysis, Targeting, Chimera, PROTAC, cereblon, E3, ubiquitin, ligase, Functionalized, Ligase, Ligands, 6628, Tocris Bioscience

Citations for TC E3 5032

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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Targeted Protein Degradation

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia