TC E3 5032

Pricing Availability   Qty
Cat.No. 6628 - TC E3 5032 | C13H9FN2O4 | CAS No. 835616-60-9
Chemical Name: 2-(2,6-Dioxo-3-piperidinyl)-4-fluoro-1H-isoindole-1,3(2H)-dione
Purity: ≥98% (HPLC)

Biological Activity

Functionalized cereblon ligand for PROTAC research and development. Precursor to Pomalidomide (Cat.No. 6302) -based PROTACs. Incorporates a fluoro leaving group to allow conjugation to amine linker. Part of a range of functionalized tool molecules for PROTAC R&D.

Technical Data

M. Wt 276.22
Formula C13H9FN2O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 835616-60-9
PubChem ID 11859051
Smiles O=C(C1=C(C=CC=C1C2=O)F)N2C3CCC(NC3=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 27.62 100

Preparing Stock Solutions

The following data is based on the product molecular weight 276.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.62 mL 18.1 mL 36.2 mL
5 mM 0.72 mL 3.62 mL 7.24 mL
10 mM 0.36 mL 1.81 mL 3.62 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

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References are publications that support the biological activity of the product.

Remillard et al (2017) Degradation of the BAF complex factor BRD9 by heterobifunctional ligands. Angew.Chem.Int.Ed.Engl. 56 5738 PMID: 28418626

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