TC-E 5006

Pricing Availability Delivery Time Qty
Cat.No. 4898 - TC-E 5006 | C29H29F4NO2 | CAS No. 1257395-14-4
Description: γ-secretase modulator; reduces Aβ42 levels
Chemical Name: 6-[(4-Fluorophenyl)(4-methyl-1-piperidinyl)methyl]-a-methyl-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-acetic acid
Purity: ≥98% (HPLC)

Biological Activity

γ-secretase modulator. Reduces Aβ42 levels in vitro (EC50 = 390 nM) and in vivo. Orally bioavailable.

Compound Libraries

TC-E 5006 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 499.54
Formula C29H29F4NO2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1257395-14-4
PubChem ID 68414868
Smiles CC(CC1)CCN1C(C2=C(C3=CC=C(C(F)(F)F)C=C3)C=C(C(C)C(O)=O)C=C2)C4=CC=C(F)C=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 49.95 100
ethanol 49.95 100

Preparing Stock Solutions

The following data is based on the product molecular weight 499.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2 mL 10.01 mL 20.02 mL
5 mM 0.4 mL 2 mL 4 mL
10 mM 0.2 mL 1 mL 2 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet


References are publications that support the products' biological activity.

Peng et al (2011) Discovery of BIIB042, a potent, selective, and orally bioavailable γ-secretase modulator. ACS Med.Chem.Lett. 2 786 PMID: 24900267

If you know of a relevant reference for TC-E 5006, please let us know.

View Related Products by Target

View Related Products by Product Action

View all γ-Secretase Modulators

Keywords: TC-E5006 biib042 γ-secretase g-secretase gamma-secretase modulators Aβ42 AB42 Abeta42 amyloid Gamma-Secretase

Citations for TC-E 5006

Citations are publications that use Tocris products.

Currently there are no citations for TC-E 5006. Do you know of a great paper that uses TC-E 5006 from Tocris? If so please let us know.

Commented out for usability testing


TODO: Add Reviews

Literature in this Area


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease

Alzheimer's Poster

Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.

Pathways for TC-E 5006


TODO: Add Protocols