TC-E 5006

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Cat.No. 4898 - TC-E 5006 | C29H29F4NO2 | CAS No. 1257395-14-4
Description: γ-secretase modulator; reduces Aβ42 levels
Chemical Name: 6-[(4-Fluorophenyl)(4-methyl-1-piperidinyl)methyl]-a-methyl-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-acetic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

γ-secretase modulator. Reduces Aβ42 levels in vitro (EC50 = 390 nM) and in vivo. Orally bioavailable.

Compound Libraries

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Technical Data

M. Wt 499.54
Formula C29H29F4NO2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1257395-14-4
PubChem ID 68414868
InChI Key ONYWALXTZFPKAS-UHFFFAOYSA-N
Smiles CC(CC1)CCN1C(C2=C(C3=CC=C(C(F)(F)F)C=C3)C=C(C(C)C(O)=O)C=C2)C4=CC=C(F)C=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.95 100
ethanol 49.95 100

Preparing Stock Solutions

The following data is based on the product molecular weight 499.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2 mL 10.01 mL 20.02 mL
5 mM 0.4 mL 2 mL 4 mL
10 mM 0.2 mL 1 mL 2 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Peng et al (2011) Discovery of BIIB042, a potent, selective, and orally bioavailable γ-secretase modulator. ACS Med.Chem.Lett. 2 786 PMID: 24900267


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Keywords: TC-E 5006, TC-E 5006 supplier, TC-E5006, biib042, γ-secretase, g-secretase, gamma-secretase, modulators, Aβ42, AB42, Abeta42, amyloid, Gamma-Secretase, 4898, Tocris Bioscience

Citations for TC-E 5006

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Literature in this Area

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