TC-E 5006

Discontinued Product

TC-E 5006 (Cat. No. 4898) has been withdrawn from sale for commercial reasons.
Description: γ-secretase modulator; reduces Aβ42 levels
Chemical Name: 6-[(4-Fluorophenyl)(4-methyl-1-piperidinyl)methyl]-a-methyl-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-acetic acid
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for TC-E 5006

TC-E 5006 is a γ-secretase modulator. Reduces Aβ42 levels in vitro (EC50 = 390 nM) and in vivo. Orally bioavailable.

Technical Data for TC-E 5006

M. Wt 499.54
Formula C29H29F4NO2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1257395-14-4
PubChem ID 68414868
Smiles CC(CC1)CCN1C(C2=C(C3=CC=C(C(F)(F)F)C=C3)C=C(C(C)C(O)=O)C=C2)C4=CC=C(F)C=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for TC-E 5006

Certificate of Analysis / Product Datasheet
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References for TC-E 5006

References are publications that support the biological activity of the product.

Peng et al (2011) Discovery of BIIB042, a potent, selective, and orally bioavailable γ-secretase modulator. ACS Med.Chem.Lett. 2 786 PMID: 24900267

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Keywords: TC-E 5006, TC-E 5006 supplier, TC-E5006, biib042, γ-secretase, g-secretase, gamma-secretase, modulators, Aβ42, AB42, Abeta42, amyloid, Gamma-Secretase, 4898, Tocris Bioscience

Citations for TC-E 5006

Citations are publications that use Tocris products.

Currently there are no citations for TC-E 5006.

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