TC-E 5006

Pricing Availability Delivery Time Qty
Cat.No. 4898 - TC-E 5006 | C29H29F4NO2 | CAS No. 1257395-14-4
Description: γ-secretase modulator; reduces Aβ42 levels
Chemical Name: 6-[(4-Fluorophenyl)(4-methyl-1-piperidinyl)methyl]-a-methyl-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-acetic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

γ-secretase modulator. Reduces Aβ42 levels in vitro (EC50 = 390 nM) and in vivo. Orally bioavailable.

Compound Libraries

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Technical Data

M. Wt 499.54
Formula C29H29F4NO2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1257395-14-4
PubChem ID 68414868
InChI Key ONYWALXTZFPKAS-UHFFFAOYSA-N
Smiles CC(CC1)CCN1C(C2=C(C3=CC=C(C(F)(F)F)C=C3)C=C(C(C)C(O)=O)C=C2)C4=CC=C(F)C=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.95 100
ethanol 49.95 100

Preparing Stock Solutions

The following data is based on the product molecular weight 499.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2 mL 10.01 mL 20.02 mL
5 mM 0.4 mL 2 mL 4 mL
10 mM 0.2 mL 1 mL 2 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Peng et al (2011) Discovery of BIIB042, a potent, selective, and orally bioavailable γ-secretase modulator. ACS Med.Chem.Lett. 2 786 PMID: 24900267


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Keywords: TC-E5006 biib042 γ-secretase g-secretase gamma-secretase modulators Aβ42 AB42 Abeta42 amyloid Gamma-Secretase

Citations for TC-E 5006

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Literature in this Area

Cancer

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Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

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Alzheimer's

Alzheimer's Poster

Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.

Pathways for TC-E 5006

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