Selective histone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.2, 1.2, 6.8, 55, 83, >100 and >120 μM for KDM7A, KDM7B, KDM2A, KDM5A, KDM4C, KDM6A and KDM4A respectively). Inhibits growth of HeLa and KYSE-150 cancer cells in vitro.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 285.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.5 mL||17.52 mL||35.04 mL|
|5 mM||0.7 mL||3.5 mL||7.01 mL|
|10 mM||0.35 mL||1.75 mL||3.5 mL|
|50 mM||0.07 mL||0.35 mL||0.7 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Suzuki et al (2013) Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity. J.Med.Chem. 56 PMID: 23964788
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Keywords: TC-E 5002, supplier, TC-E5002, histone, demthylases, KDM2/7, KDM2A, KDM7A, KDM7B, subfamily, inhibitors, inhibits, Histone, Demethylases, Tocris Bioscience
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Literature in this Area
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Epigenetics Research Bulletin
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