TC-E 5002

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Cat.No. 5089 - TC-E 5002 | C15H27NO4 | CAS No. 1453071-47-0
Description: Selective KDM2/7 inhibitor
Chemical Name: N-(9-Cyclopropyl-1-oxononyl)-N-hydroxy-β-alanine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective histone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.2, 1.2, 6.8, 55, 83, >100 and >120 μM for KDM7A, KDM7B, KDM2A, KDM5A, KDM4C, KDM6A and KDM4A respectively). Inhibits growth of HeLa and KYSE-150 cancer cells in vitro.

Compound Libraries

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Technical Data

M. Wt 285.38
Formula C15H27NO4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1453071-47-0
PubChem ID 71735843
InChI Key NEHSERYKENINRH-UHFFFAOYSA-N
Smiles O=C(N(CCC(O)=O)O)CCCCCCCCC1CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.54 100
1eq. NaOH 28.54 100

Preparing Stock Solutions

The following data is based on the product molecular weight 285.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.5 mL 17.52 mL 35.04 mL
5 mM 0.7 mL 3.5 mL 7.01 mL
10 mM 0.35 mL 1.75 mL 3.5 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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References

References are publications that support the biological activity of the product.

Suzuki et al (2013) Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity. J.Med.Chem. 56 PMID: 23964788


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Keywords: TC-E 5002, TC-E 5002 supplier, TC-E5002, histone, demthylases, KDM2/7, KDM2A, KDM7A, KDM7B, subfamily, inhibitors, inhibits, Histone, Demethylases, 5089, Tocris Bioscience

Citations for TC-E 5002

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Literature in this Area

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