TC-E 5002

Pricing Availability   Qty
Description: Selective KDM2/7 inhibitor
Chemical Name: N-(9-Cyclopropyl-1-oxononyl)-N-hydroxy-β-alanine
Purity: ≥98% (HPLC)
Citations (1)
Literature (1)

Biological Activity for TC-E 5002

TC-E 5002 is a selective histone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.2, 1.2, 6.8, 55, 83, >100 and >120 μM for KDM7A, KDM7B, KDM2A, KDM5A, KDM4C, KDM6A and KDM4A respectively). Inhibits growth of HeLa and KYSE-150 cancer cells in vitro.

Compound Libraries for TC-E 5002

TC-E 5002 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for TC-E 5002

M. Wt 285.38
Formula C15H27NO4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1453071-47-0
PubChem ID 71735843

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TC-E 5002

Solvent Max Conc. mg/mL Max Conc. mM
1eq. NaOH 28.54 100
DMSO 28.54 100

Preparing Stock Solutions for TC-E 5002

The following data is based on the product molecular weight 285.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.5 mL 17.52 mL 35.04 mL
5 mM 0.7 mL 3.5 mL 7.01 mL
10 mM 0.35 mL 1.75 mL 3.5 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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References for TC-E 5002

References are publications that support the biological activity of the product.

Suzuki et al (2013) Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity. J.Med.Chem. 56 PMID: 23964788

If you know of a relevant reference for TC-E 5002, please let us know.

View Related Products by Target

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View all Histone Demethylase Inhibitors

Keywords: TC-E 5002, TC-E 5002 supplier, TC-E5002, histone, demthylases, KDM2/7, KDM2A, KDM7A, KDM7B, subfamily, inhibitors, inhibits, Histone, Demethylases, 5089, Tocris Bioscience

1 Citation for TC-E 5002

Citations are publications that use Tocris products. Selected citations for TC-E 5002 include:

David E et al (2022) NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition. Mol Cell 82 2472-2489.e8 PMID: 35537449

Do you know of a great paper that uses TC-E 5002 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.