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Potent and selective, ATP-competitive inhibitor of death-associated protein kinase 1 (DAPK1) (IC50 values are 69 and 225 nM for DAPK1 and DAPK3 respectively, when assayed with 10 μM ATP). Displays selectivity for DAPK1 over a range of 48 other kinases, including Abl, AMPK, Chk1, Met and Src (IC50 > 10 μM).
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 276.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||7.24 mL||36.19 mL||72.39 mL|
|2.5 mM||1.45 mL||7.24 mL||14.48 mL|
|5 mM||0.72 mL||3.62 mL||7.24 mL|
|25 mM||0.14 mL||0.72 mL||1.45 mL|
References are publications that support the biological activity of the product.
Okamoto et al (2009) Identification of death-associated protein kinases inhibitors using structure-based virtual screening. J.Med.Chem. 52 7323 PMID: 19877644
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Keywords: TC-DAPK 6, TC-DAPK 6 supplier, TC-DAPK6, death-associated, protein, kinase, dapk1, selective, potent, inhibitors, inhibits, 315694-89-4, DAPK, 4301, Tocris Bioscience
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