TC-C 14G

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Cat.No. 4345 - TC-C 14G | C24H17Cl2F2NO4 | CAS No. 656804-72-7
Description: High affinity and potent CB1 inverse agonist
Chemical Name: [2-(2,4-Dichlorophenyl)-6-fluoro-2-(4-fluorophenyl)-1,3-benzodioxol-5-yl]-4-morpholinyl-methanone
Purity: ≥98% (HPLC)
Literature (6)

Biological Activity

Potent, high affinity CB1 receptor inverse agonist (EC50 = 11 nM in cAMP assay; Ki = 4 nM). Demonstrates high efficacy in a hypothermia assay (ID50 = 5 mg/kg) in vivo.

Technical Data

M. Wt 492.3
Formula C24H17Cl2F2NO4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 656804-72-7
PubChem ID 22475020
Smiles FC1=CC2=C(OC(C3=C(Cl)C=C(Cl)C=C3)(C4=CC=C(F)C=C4)O2)C=C1C(N5CCOCC5)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 49.23 100
ethanol 49.23 100

Preparing Stock Solutions

The following data is based on the product molecular weight 492.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.03 mL 10.16 mL 20.31 mL
5 mM 0.41 mL 2.03 mL 4.06 mL
10 mM 0.2 mL 1.02 mL 2.03 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

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References are publications that support the biological activity of the product.

Alig et al (2008) Benzodioxoles: novel cannabinoid-1 receptor inverse agonists for the treatment of obesity. J.Med.Chem. 51 2115 PMID: 18335976

If you know of a relevant reference for TC-C 14G, please let us know.

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Keywords: TC-C 14G, TC-C 14G supplier, TC-C14G, cannabinoid, CB1, receptor, inverse, agonists, potent, high, affinity, Receptors, 4345, Tocris Bioscience

Citations for TC-C 14G

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