TC-C 14G

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Cat.No. 4345 - TC-C 14G | C24H17Cl2F2NO4 | CAS No. 656804-72-7
Description: Potent, high affinity CB1 receptor inverse agonist
Chemical Name: [2-(2,4-Dichlorophenyl)-6-fluoro-2-(4-fluorophenyl)-1,3-benzodioxol-5-yl]-4-morpholinyl-methanone
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent, high affinity CB1 receptor inverse agonist (EC50 = 11 nM in cAMP assay; Ki = 4 nM). Demonstrates high efficacy in a hypothermia assay (ID50 = 5 mg/kg) in vivo.

Technical Data

M. Wt 492.3
Formula C24H17Cl2F2NO4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 656804-72-7
PubChem ID 22475020
InChI Key VUCKSZWMRCSPME-UHFFFAOYSA-N
Smiles FC1=CC2=C(OC(C3=C(Cl)C=C(Cl)C=C3)(C4=CC=C(F)C=C4)O2)C=C1C(N5CCOCC5)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.23 100
ethanol 49.23 100

Preparing Stock Solutions

The following data is based on the product molecular weight 492.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.03 mL 10.16 mL 20.31 mL
5 mM 0.41 mL 2.03 mL 4.06 mL
10 mM 0.2 mL 1.02 mL 2.03 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Alig et al (2008) Benzodioxoles: novel cannabinoid-1 receptor inverse agonists for the treatment of obesity. J.Med.Chem. 51 2115 PMID: 18335976


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Keywords: TC-C 14G, supplier, TC-C14G, cannabinoid, CB1, receptor, inverse, agonists, potent, high, affinity, CB1, Receptors, CB1, Receptors, Tocris Bioscience

Citations for TC-C 14G

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