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High affinity σ1 receptor ligand that displays selectivity over σ2 receptors (Ki values are 10 and 370 nM respectively). Exhibits low affinity for dopamine (DAT), serotonin (SERT) and noradrenalin (NET) transporters (Ki > 10 μM) and low affinity for dopamine D2 receptors (Ki = 1226 nM). Attenuates cocaine-induced locomotor activity in mice.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||14.87||50 with gentle warming|
|ethanol||14.87||50 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 297.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||6.73 mL||33.63 mL||67.26 mL|
|2.5 mM||1.35 mL||6.73 mL||13.45 mL|
|5 mM||0.67 mL||3.36 mL||6.73 mL|
|25 mM||0.13 mL||0.67 mL||1.35 mL|
References are publications that support the biological activity of the product.
Liu et al (2007) Trishomocubanes: novel σ ligands modulate cocaine-induced behavioural effects. Eur.J.Pharmacol. 555 37 PMID: 17113074
If you know of a relevant reference for TC 1, please let us know.
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Keywords: TC 1, TC 1 supplier, High, affinity, σ1, sigma1, ligands, Receptors, TC1, Sigma1, 2669, Tocris Bioscience
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