TC 1

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Cat.No. 2669 - TC 1 | C19H20FNO | CAS No. 362512-81-0
Description: High affinity σ1 ligand
Chemical Name: (N-(3'-Fluorophenyl)ethyl-4-azahexacyclo[,6.03,10.05,9.08,11]dodecan-3-ol
Purity: ≥99% (HPLC)

Biological Activity for TC 1

TC 1 is a high affinity σ1 receptor ligand that displays selectivity over σ2 receptors (Ki values are 10 and 370 nM respectively). Exhibits low affinity for dopamine (DAT), serotonin (SERT) and noradrenalin (NET) transporters (Ki > 10 μM) and low affinity for dopamine D2 receptors (Ki = 1226 nM). Attenuates cocaine-induced locomotor activity in mice.

Compound Libraries for TC 1

TC 1 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for TC 1

M. Wt 297.37
Formula C19H20FNO
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 362512-81-0
PubChem ID 10040286
Smiles OC12C3C4C5C3C(C3C5CC4C13)N2CCC1=CC(F)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TC 1

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 14.87 50 with gentle warming
ethanol 14.87 50 with gentle warming

Preparing Stock Solutions for TC 1

The following data is based on the product molecular weight 297.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 6.73 mL 33.63 mL 67.26 mL
2.5 mM 1.35 mL 6.73 mL 13.45 mL
5 mM 0.67 mL 3.36 mL 6.73 mL
25 mM 0.13 mL 0.67 mL 1.35 mL

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Product Datasheets for TC 1

Certificate of Analysis / Product Datasheet
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References for TC 1

References are publications that support the biological activity of the product.

Liu et al (2007) Trishomocubanes: novel σ ligands modulate cocaine-induced behavioural effects. Eur.J.Pharmacol. 555 37 PMID: 17113074

If you know of a relevant reference for TC 1, please let us know.

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Citations for TC 1

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