Home / Pharmacology / Other Pharmacology / Sigma Receptors / σ1 Receptors / σ1 Receptor Ligands / TC 1

TC 1

Cat. No. 2669 COA / Product Datasheet SDS
Pricing Availability Delivery Time Qty
Cat.No. 2669 - TC 1 | C19H20FNO | CAS No. 362512-81-0
Description: High affinity σ1 ligand
Chemical Name: (N-(3'-Fluorophenyl)ethyl-4-azahexacyclo[5.4.1.02,6.03,10.05,9.08,11]dodecan-3-ol
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

High affinity σ1 receptor ligand that displays selectivity over σ2 receptors (Ki values are 10 and 370 nM respectively). Exhibits low affinity for dopamine (DAT), serotonin (SERT) and noradrenalin (NET) transporters (Ki > 10 μM) and low affinity for dopamine D2 receptors (Ki = 1226 nM). Attenuates cocaine-induced locomotor activity in mice.

Technical Data

M. Wt 297.37
Formula C19H20FNO
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 362512-81-0
PubChem ID 10040286
InChI Key FYGREZKTJIXWIH-UHFFFAOYSA-N
Smiles OC12C3C4C5C3C(C3C5CC4C13)N2CCC1=CC(F)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 14.87 50mM with gentle warming
ethanol 14.87 50mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 297.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.36 mL 16.81 mL 33.63 mL
5 mM 0.67 mL 3.36 mL 6.73 mL
10 mM 0.34 mL 1.68 mL 3.36 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Liu et al (2007) Trishomocubanes: novel σ ligands modulate cocaine-induced behavioural effects. Eur.J.Pharmacol. 555 37 PMID: 17113074

If you know of a relevant reference for TC 1, please let us know.

View Related Products by Target

View Related Products by Product Action

View all σ1 Receptor Ligands

Keywords: TC 1, supplier, High, affinity, σ1, sigma1, ligands, Receptors, TC1, Sigma1, Receptors, Sigma1, Receptors, Tocris Bioscience

Citations for TC 1

Citations are publications that use Tocris products.

Currently there are no citations for TC 1. Do you know of a great paper that uses TC 1 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for TC 1

Protocols

TODO: Add Protocols