Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewTC 1
Description: High affinity σ1 ligand
Chemical Name: (N-(3'-Fluorophenyl)ethyl-4-azahexacyclo[5.4.1.02,6.03,10.05,9.08,11]dodecan-3-ol
Purity: ≥99% (HPLC)
Biological Activity
High affinity σ1 receptor ligand that displays selectivity over σ2 receptors (Ki values are 10 and 370 nM respectively). Exhibits low affinity for dopamine (DAT), serotonin (SERT) and noradrenalin (NET) transporters (Ki > 10 μM) and low affinity for dopamine D2 receptors (Ki = 1226 nM). Attenuates cocaine-induced locomotor activity in mice.
Technical Data
| M. Wt | 297.37 |
| Formula | C19H20FNO |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 362512-81-0 |
| PubChem ID | 10040286 |
| InChI Key | FYGREZKTJIXWIH-UHFFFAOYSA-N |
| Smiles | OC12C3C4C5C3C(C3C5CC4C13)N2CCC1=CC(F)=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 14.87 | 50 with gentle warming | |
| ethanol | 14.87 | 50 with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 297.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 6.73 mL | 33.63 mL | 67.26 mL |
| 2.5 mM | 1.35 mL | 6.73 mL | 13.45 mL |
| 5 mM | 0.67 mL | 3.36 mL | 6.73 mL |
| 25 mM | 0.13 mL | 0.67 mL | 1.35 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets
References
References are publications that support the biological activity of the product.
Liu et al (2007) Trishomocubanes: novel σ ligands modulate cocaine-induced behavioural effects. Eur.J.Pharmacol. 555 37 PMID: 17113074
If you know of a relevant reference for TC 1, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: TC 1, TC 1 supplier, High, affinity, σ1, sigma1, ligands, Receptors, TC1, Sigma1, 2669, Tocris Bioscience
Citations for TC 1
Citations are publications that use Tocris products.
Currently there are no citations for TC 1. Do you know of a great paper that uses TC 1 from Tocris? Please let us know.
Reviews for TC 1
There are currently no reviews for this product. Be the first to review TC 1 and earn rewards!
Have you used TC 1?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
New Product Guide [Spring/Summer 2019]New
Our new product guide highlights over 215 new products added to the Tocris Bioscience range during the first half of 2019.
- 7-TM Receptors
- Enzymes
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Transporters
- Chemogenetics
- Epigenetics
- Fluorescent Imaging
- PROTACs
- Signal Transduction
- Stem Cells