TC 1

Pricing Availability Delivery Time Qty
Cat.No. 2669 - TC 1 | C19H20FNO | CAS No. 362512-81-0
Description: High affinity σ1 ligand
Chemical Name: (N-(3'-Fluorophenyl)ethyl-4-azahexacyclo[5.4.1.02,6.03,10.05,9.08,11]dodecan-3-ol
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

High affinity σ1 receptor ligand that displays selectivity over σ2 receptors (Ki values are 10 and 370 nM respectively). Exhibits low affinity for dopamine (DAT), serotonin (SERT) and noradrenalin (NET) transporters (Ki > 10 μM) and low affinity for dopamine D2 receptors (Ki = 1226 nM). Attenuates cocaine-induced locomotor activity in mice.

Technical Data

M. Wt 297.37
Formula C19H20FNO
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 362512-81-0
PubChem ID 10040286
InChI Key FYGREZKTJIXWIH-UHFFFAOYSA-N
Smiles OC12C3C4C5C3C(C3C5CC4C13)N2CCC1=CC(F)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 14.87 50mM with gentle warming
ethanol 14.87 50mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 297.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.36 mL 16.81 mL 33.63 mL
5 mM 0.67 mL 3.36 mL 6.73 mL
10 mM 0.34 mL 1.68 mL 3.36 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Liu et al (2007) Trishomocubanes: novel σ ligands modulate cocaine-induced behavioural effects. Eur.J.Pharmacol. 555 37 PMID: 17113074


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Keywords: High affinity σ1 sigma1 ligands Receptors TC1 Sigma1 Receptors

Citations for TC 1

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Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for TC 1

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