Tautomycetin

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Cat.No. 2305 - Tautomycetin | C33H50O10 | CAS No. 119757-73-2
Description: Selective PP1 inhibitor
Chemical Name: (1R,2S,3R,6S,7S,10S,12R,15E,βR,3R)-16-Ethyl-3,7-dihydroxy-1,2,6,10,12-pentamethyl-5,14-dioxo-15,17-octadecadienyl 2,5-dihydro-β-hydroxy-4-methyl-2,5-dioxo-3-furanpropanoic acid ester
Purity: ≥95% (HPLC)
Datasheet
Citations (11)
Reviews
Literature

Biological Activity

Selective inhibitor of protein phosphatase (PP)1 (IC50 values are 1.6 and 62 nM for PP1 and PP2 respectively). Reduces PDGF-induced vascular smooth muscle cell and mesangial cell proliferation without affecting fibronectin secretion and cellular kinase activation in vivo. Immunosuppressive agent; inhibits proliferation and induces apoptosis in activated T cells.

Technical Data

M. Wt 606.75
Formula C33H50O10
Storage Desiccate at -20°C
Purity ≥95% (HPLC)
CAS Number 119757-73-2
PubChem ID 16759609
InChI Key VAIBGAONSFVVKI-CIFLJJJCSA-N
Smiles O=C(O1)C([C@H](O)CC(O[C@H](C)[C@@H](C)[C@H](O)CC([C@@H](C)[C@@H](O)CC[C@H](C)C[C@@H](C)CC(/C=C(CC)/C=C)=O)=O)=O)=C(C)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml)

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Mitsuhashi et al (2001) Tautomycetin is a novel and specific inhibitor of serine/threonine protein phosphatase type 1, PP1. Biochem.Biophys.Res.Comm. 287 328 PMID: 11554729

Shim et al (2002) Immunosuppressive effects of tautomycetin in vivo and in vitro via T cell-specific apoptosis induction. Proc.Natl.Acad.Sci.USA. 99 10617 PMID: 12149481

Kim et al (2005) Effects of tautomycetin on proliferation and fibronectin secretion in vascular smooth muscle cells and glomerular mesangial cells. Transplant Proc. 37 1959 PMID: 15919517


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Keywords: Tautomycetin, Tautomycetin supplier, Selective, PP1, inhibitors, inhibits, Calcineurin, Protein, Ser/Thr, Phosphatases, immunosuppressants, transplant, PP2, TC, Immunosuppressants, 2305, Tocris Bioscience

11 Citations for Tautomycetin

Citations are publications that use Tocris products. Selected citations for Tautomycetin include:

Liu (2018) In vivo brain GPCR signaling elucidated by phosphoproteomics. Science 360 eaao4927 PMID: 29930108

Toledo et al (2013) A novel effect of MARCKS phosphorylation by activated PKC: the dephosphorylation of its serine 25 in chick neuroblasts. PLoS One 8 e62863 PMID: 23634231

Alver et al (2017) Reversal of DDK-Mediated MCM Phosphorylation by Rif1-PP1 Regulates Replication Initiation and Replisome Stability Independently of ATR/Chk1. Cell Rep 18 2508 PMID: 28273463

Engmann et al (2015) DARPP-32 interaction with adducin may mediate rapid environmental effects on striatal neurons. Nat Commun 6 10099 PMID: 26639316

Walsh and Young (2011) TGF-β regulation of focal adhesion proteins and motility of premalignant oral lesions via protein phosphatase 1. Anticancer Res 31 3159 PMID: 21965722

Mirante et al (2014) Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala. PLoS Genet 7 62 PMID: 25071439

Hégarat et al (2014) PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit. Anticancer Res 10 e1004004 PMID: 24391510

Huang et al (2014) PP1γ functionally augments the alternative splicing of CaMKIIδ through interaction with ASF. Am J Physiol Cell Physiol 306 C167 PMID: 24196533

Walsh and Young (2010) Interrelationship between protein phosphatase 1 and TGF-{β} in regulating motility and cytoskeletal architecture of endothelial cells. J Neurosci 30 4861 PMID: 21187463

Pribiag and Stellwagen (2013) TNF-α Downregulates Inhibitory Neurotransmission through Protein Phosphatase 1-Dependent Trafficking of GABAA Receptors. Front Neurosci 33 15879 PMID: 24089494

Isensee et al (2014) Pain modulators regulate the dynamics of PKA-RII phosphorylation in subgroups of sensory neurons. J Cell Sci 127 216 PMID: 24190886


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