TAT 14
Biological Activity
Nrf2 activator; inhibits Nrf2/Keap1 interaction. Induces upregulation of Nrf2 pathway downstream gene expression including heme-oxygenase 1. Suppresses LPS-induced TNF-α expression in THP-1 cells.
Technical Data
| M. Wt | 3173.6 |
| Formula | C137H230N48O39 |
| Sequence | YGRKKRRQRRRLQLDEETGEFLPIQ |
| Storage | Store at -20°C |
| CAS Number | 1362661-34-4 |
| PubChem ID | 60150581 |
| InChI Key | NBFQPSCRGQGZEP-YBKRDZSWSA-N |
| Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 3173.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.32 mL | 1.58 mL | 3.15 mL |
| 5 mM | 0.06 mL | 0.32 mL | 0.63 mL |
| 10 mM | 0.03 mL | 0.16 mL | 0.32 mL |
| 50 mM | 0.01 mL | 0.03 mL | 0.06 mL |
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References
References are publications that support the products' biological activity.
Steel et al (2012) Anti-inflammatory effect of a cell-penetrating peptide targeting the Nrf2/Keap1 interaction. ACS Med.Chem.Lett. 3 407 PMID: 22582137
If you know of a relevant reference for TAT 14, please let us know.
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Keywords: TAT14 Nrf2 pathway activators Keap1 Cullin3 ARE antioxidants response element heme oxygenase 1 HO1 Nrf2
Citations for TAT 14
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