TAS 301

Pricing Availability Delivery Time Qty
Cat.No. 4521 - TAS 301 | C23H19NO3 | CAS No. 193620-69-8
Description: Inhibitor of smooth muscle cell migration and proliferation
Chemical Name: 3-[Bis(4-methoxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one
Purity: ≥99% (HPLC)

Biological Activity

Inhibitor of smooth muscle cell migration and proliferation. Blocks voltage-independent calcium influx and downstream PKC signaling. Inhibits neointimal thickening after balloon catheter injury to the rat common carotid artery.

Technical Data

M. Wt 357.4
Formula C23H19NO3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 193620-69-8
PubChem ID 9885087
Smiles O=C2NC1=CC=CC=C1/C2=C(C4=CC=C(OC)C=C4)\C3=CC=C(OC)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 35.74 100

Preparing Stock Solutions

The following data is based on the product molecular weight 357.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.8 mL 13.99 mL 27.98 mL
5 mM 0.56 mL 2.8 mL 5.6 mL
10 mM 0.28 mL 1.4 mL 2.8 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Muranaka et al (1998) TAS-301, an inhibitor of smooth muscle cell migration and proliferation, inhibits intimal thickening after balloon injury to rat carotid arteries. J.Pharmacol.Exp.Ther. 285 1280 PMID: 9618434

Sasaki et al (2000) TAS-301 blocks receptor-operated calcium influx and inhibits rat vascular smooth muscle cell proliferation induced by basic fibroblast growth factor and platelet-derived growth factor. Jpn.J.Pharmacol. 84 252 PMID: 11138725

If you know of a relevant reference for TAS 301, please let us know.

View Related Products by Target

Keywords: TAS 301, supplier, TAS301, smooth, muscles, cells, migration, proliferation, blockers, inhibitors, inhibits, voltage-independent, calcium, influx, neointimal, thickening, stenosis, angioplasty, restenosis, Miscellaneous, Compounds, Miscellaneous, Compounds, Tocris Bioscience

Citations for TAS 301

Citations are publications that use Tocris products.

Currently there are no citations for TAS 301. Do you know of a great paper that uses TAS 301 from Tocris? If so please let us know.

Commented out for usability testing


TODO: Add Reviews

Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for TAS 301


TODO: Add Protocols