TAS 301

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Cat.No. 4521 - TAS 301 | C23H19NO3 | CAS No. 193620-69-8
Description: Inhibitor of smooth muscle cell migration and proliferation
Chemical Name: 3-[Bis(4-methoxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one
Purity: ≥99% (HPLC)
Literature (1)

Biological Activity

Inhibitor of smooth muscle cell migration and proliferation. Blocks voltage-independent calcium influx and downstream PKC signaling. Inhibits neointimal thickening after balloon catheter injury to the rat common carotid artery.

Technical Data

M. Wt 357.4
Formula C23H19NO3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 193620-69-8
PubChem ID 9885087
Smiles O=C2NC1=CC=CC=C1/C2=C(C4=CC=C(OC)C=C4)\C3=CC=C(OC)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 35.74 100

Preparing Stock Solutions

The following data is based on the product molecular weight 357.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.8 mL 13.99 mL 27.98 mL
5 mM 0.56 mL 2.8 mL 5.6 mL
10 mM 0.28 mL 1.4 mL 2.8 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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References are publications that support the biological activity of the product.

Muranaka et al (1998) TAS-301, an inhibitor of smooth muscle cell migration and proliferation, inhibits intimal thickening after balloon injury to rat carotid arteries. J.Pharmacol.Exp.Ther. 285 1280 PMID: 9618434

Sasaki et al (2000) TAS-301 blocks receptor-operated calcium influx and inhibits rat vascular smooth muscle cell proliferation induced by basic fibroblast growth factor and platelet-derived growth factor. Jpn.J.Pharmacol. 84 252 PMID: 11138725

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View Related Products by Target

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