Tandospirone hydrochloride

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Description: Selective 5-HT1A partial agonist
Alternative Names: SM-3997
Chemical Name: (3aR,4S,7R,7aS)-rel-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dione hydrochloride
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity for Tandospirone hydrochloride

Tandospirone hydrochloride is a 5-HT1A receptor partial agonist (Ki = 27 nM) that displays selectivity over 5-HT2, 5-HT1C, α1, α2, D1 and D2 receptors (Ki values ranging from 1300 - 41000 nM). Inactive at 5-HT uptake sites, 5-HT1B, β-adrenergic, muscarinic and benzodiazepine receptors. Displays anxiolytic activity.

Technical Data for Tandospirone hydrochloride

M. Wt 419.95
Formula C21H29N5O2.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 99095-10-0
PubChem ID 13422623
Smiles [H][C@]13[C@](C(N(CCCCN4CCN(C5=NC=CC=N5)CC4)C3=O)=O)([H])[C@@H]2CC[C@H]1C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Tandospirone hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 41.99 100
DMSO 41.99 100

Preparing Stock Solutions for Tandospirone hydrochloride

The following data is based on the product molecular weight 419.95. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.38 mL 11.91 mL 23.81 mL
5 mM 0.48 mL 2.38 mL 4.76 mL
10 mM 0.24 mL 1.19 mL 2.38 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets for Tandospirone hydrochloride

Certificate of Analysis / Product Datasheet
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References for Tandospirone hydrochloride

References are publications that support the biological activity of the product.

Hamik et al (1990) Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites. Biol.Psychiatry 28 99 PMID: 1974152

Pollard et al (1992) Effects of tandospirone in three behavioral tests for anxiolytics. Eur.J.Pharmacol. 221 297 PMID: 1358655

Matsubara et al (2006) Tandospirone, a 5-HT1A agonist, ameliorates movement disorder via non-DArgic systems in rats with unilateral 6-hydroxyDA-generated lesions. Brain Res. 1112 126 PMID: 16884702

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Keywords: Tandospirone hydrochloride, Tandospirone hydrochloride supplier, Selective, 5-HT1A, partial, agonists, Serotonin, Receptors, SM3997, SM-3997, 2854, Tocris Bioscience

Citations for Tandospirone hydrochloride

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.