Tandospirone hydrochloride

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Cat.No. 2854 - Tandospirone hydrochloride | C21H29N5O2.HCl | CAS No. 99095-10-0
Description: Selective 5-HT1A partial agonist
Alternative Names: SM-3997
Chemical Name: (3aR,4S,7R,7aS)-rel-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dione hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

5-HT1A receptor partial agonist (Ki = 27 nM) that displays selectivity over 5-HT2, 5-HT1C, α1, α2, D1 and D2 receptors (Ki values ranging from 1300 - 41000 nM). Inactive at 5-HT uptake sites, 5-HT1B, β-adrenergic, muscarinic and benzodiazepine receptors. Displays anxiolytic activity.

Compound Libraries

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Technical Data

M. Wt 419.95
Formula C21H29N5O2.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 99095-10-0
PubChem ID 13422623
InChI Key ACVFJYKNBOHIMH-DPFKZJTMSA-N
Smiles [H][C@]13[C@](C(N(CCCCN4CCN(C5=NC=CC=N5)CC4)C3=O)=O)([H])[C@@H]2CC[C@H]1C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.99 100
water 41.99 100

Preparing Stock Solutions

The following data is based on the product molecular weight 419.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.38 mL 11.91 mL 23.81 mL
5 mM 0.48 mL 2.38 mL 4.76 mL
10 mM 0.24 mL 1.19 mL 2.38 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Hamik et al (1990) Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites. Biol.Psychiatry 28 99 PMID: 1974152

Pollard et al (1992) Effects of tandospirone in three behavioral tests for anxiolytics. Eur.J.Pharmacol. 221 297 PMID: 1358655

Matsubara et al (2006) Tandospirone, a 5-HT1A agonist, ameliorates movement disorder via non-dopaminergic systems in rats with unilateral 6-hydroxydopamine-generated lesions. Brain Res. 1112 126 PMID: 16884702


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Keywords: Selective 5-HT1A partial agonists Serotonin Receptors SM3997 SM-3997 5-HT1A Receptors

Citations for Tandospirone hydrochloride

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Pathways for Tandospirone hydrochloride

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