Potent, selective inhibitor of the noradrenalin transporter (NET) (IC50 = 2.9 nM). Exhibits selectivity for NET against SERT (5-HT transporters) and DAT (dopamine transporters). Displays a similar structure but different pharmacological profile to citalopram (Cat. No. 1427).
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 331.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.01 mL||15.07 mL||30.13 mL|
|5 mM||0.6 mL||3.01 mL||6.03 mL|
|10 mM||0.3 mL||1.51 mL||3.01 mL|
|50 mM||0.06 mL||0.3 mL||0.6 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Bogeso et al (1985) 3-phenyl-1-indanamines. Potential antidepressant activity and potent inhibition of dopamine, norepinephrine, and serotonin uptake. J.Med.Chem. 28 1817 PMID: 2999402
Eildal et al (2008) From the selective serotonin transporter inhibitor citalopram to the selective norepinephrine transporter inhibitor talopram: synthesis and structure-activity relationship studies. J.Med.Chem. 51 3045 PMID: 18429609
Schou et al (2006) Synthesis and positron emission tomography evaluation of three norepinephrine transporter radioligands: [C-11]desipramine, [C-11]talopram and [C-11]talsupram. Mol.Imaging Biol. 8 1 PMID:
If you know of a relevant reference for Talopram hydrochloride, please let us know.
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Keywords: Talopram hydrochloride, supplier, potent, selective, inhibitors, inhibits, noradrenalin, epinephrine, adrenergics, transporters, net, Lu3-010, noradrenaline, Lu, 3-010, Adrenergic, Transporters, Tocris Bioscience
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