Talopram hydrochloride

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Cat.No. 3145 - Talopram hydrochloride | C20H25NO.HCl | CAS No. 7013-41-4
Description: Potent, selective inhibitor of noradrenalin transporters
Alternative Names: Lu 3-010
Chemical Name: 1,3-Dihydro-N,3,3-trimethyl-1-phenyl-1-isobenzofuranpropanamine hydrochloride
Purity: ≥99% (HPLC)
Literature (1)

Biological Activity for Talopram hydrochloride

Talopram hydrochloride is a potent, selective inhibitor of the noradrenalin transporter (NET) (IC50 = 2.9 nM). Exhibits selectivity for NET against SERT (5-HT transporters) and DAT (dopamine transporters). Displays a similar structure but different pharmacological profile to citalopram (Cat. No. 1427).

Technical Data for Talopram hydrochloride

M. Wt 331.88
Formula C20H25NO.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 7013-41-4
PubChem ID 71176
Smiles CC2(C)OC(C3=CC=CC=C3)(CCCNC)C1=CC=CC=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Talopram hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 16.59 50
DMSO 33.19 100

Preparing Stock Solutions for Talopram hydrochloride

The following data is based on the product molecular weight 331.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.01 mL 15.07 mL 30.13 mL
5 mM 0.6 mL 3.01 mL 6.03 mL
10 mM 0.3 mL 1.51 mL 3.01 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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Product Datasheets for Talopram hydrochloride

References for Talopram hydrochloride

References are publications that support the biological activity of the product.

Bogeso et al (1985) 3-phenyl-1-indanamines. Potential antidepressant activity and potent inhibition of DA, NE, and serotonin uptake. J.Med.Chem. 28 1817 PMID: 2999402

Eildal et al (2008) From the selective serotonin transporter inhibitor cital. to the selective NE transporter inhibitor talopram: synthesis and structure-activity relationship studies. J.Med.Chem. 51 3045 PMID: 18429609

Schou et al (2006) Synthesis and positron emission tomography evaluation of three NE transporter radioligands: [C-11]desipramine, [C-11]talopram and [C-11]talsupram. Mol.Imaging Biol. 8 1

If you know of a relevant reference for Talopram hydrochloride, please let us know.

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