Discontinued ProductUnfortunately tADA (Cat. No. 0860) has been withdrawn from sale for commercial reasons.
Group I selective metabotropic glutamate receptor agonist. More potent at mGlu5a than mGlu1a in LLC-PKI cells and induces calcium release in CA3 pyramidal cells in vitro.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 145.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||6.89 mL||34.46 mL||68.91 mL|
|5 mM||1.38 mL||6.89 mL||13.78 mL|
|10 mM||0.69 mL||3.45 mL||6.89 mL|
|50 mM||0.14 mL||0.69 mL||1.38 mL|
References are publications that support the products' biological activity.
Kozikowski et al (1993) Synthesis and metabotropic receptor activity of the novel rigidified glutamate analogues (+) and (-)-trans-azetidine-2,4,-dicarboxylic acid and their N-methyl derivatives. J.Med.Chem. 36 2706 PMID: 8410984
Manahan-Vaughan et al (1996) Physiological and pharmalogical profile of trans-azetidine-2,4-dicarboxylic acid: metabotropic glutamate receptor agonism and effects on long-term potentiation. Neuroscience 72 999 PMID: 8735225
Takeda et al (2007) Role of zinc influx via AMPA/Kainate receptor activation in metabotropic glutamate receptor-mediated calcium release. J.Neurosci.Res. 85 1310 PMID: 17304583
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Keywords: tADA, supplier, Group, I, agonists, mGlu5, mGluR5, selectivity, Receptors, mGlu1, mGluR1, Glutamate, Metabotropic, Glutamate, (Metabotropic), Group, I, Receptors, Glutamate, (Metabotropic), Group, I, Receptors, Tocris Bioscience
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