Discontinued Product

tADA (Cat. No. 0860) has been withdrawn from sale for commercial reasons.
Cat.No. 0860 - tADA | C5H7NO4 | CAS No. 161596-62-9
Description: Group I agonist; some mGlu5 selectivity
Chemical Name: trans-Azetidine-2,4-dicarboxylic acid

Biological Activity

Group I selective metabotropic glutamate receptor agonist. More potent at mGlu5a than mGlu1a in LLC-PKI cells and induces calcium release in CA3 pyramidal cells in vitro.

Technical Data

M. Wt 145.11
Formula C5H7NO4
Storage Store at RT
CAS Number 161596-62-9
Smiles O=[C@@]([C@@H]1C[C@@H]([C@@](O)=O)N1)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Kozikowski et al (1993) Synthesis and metabotropic receptor activity of the novel rigidified glutamate analogues (+) and (-)-trans-azetidine-2,4,-dicarboxylic acid and their N-methyl derivatives. J.Med.Chem. 36 2706 PMID: 8410984

Manahan-Vaughan et al (1996) Physiological and pharmalogical profile of trans-azetidine-2,4-dicarboxylic acid: metabotropic glutamate receptor agonism and effects on long-term potentiation. Neuroscience 72 999 PMID: 8735225

Takeda et al (2007) Role of zinc influx via AMPA/Kainate receptor activation in metabotropic glutamate receptor-mediated calcium release. J.Neurosci.Res. 85 1310 PMID: 17304583

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Keywords: tADA, tADA supplier, Group, I, agonists, mGlu5, mGluR5, selectivity, Receptors, mGlu1, mGluR1, Glutamate, Metabotropic, (Metabotropic), 0860, Tocris Bioscience

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