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Group I selective metabotropic glutamate receptor agonist. More potent at mGlu5a than mGlu1a in LLC-PKI cells and induces calcium release in CA3 pyramidal cells in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Kozikowski et al (1993) Synthesis and metabotropic receptor activity of the novel rigidified glutamate analogues (+) and (-)-trans-azetidine-2,4,-dicarboxylic acid and their N-methyl derivatives. J.Med.Chem. 36 2706 PMID: 8410984
Manahan-Vaughan et al (1996) Physiological and pharmalogical profile of trans-azetidine-2,4-dicarboxylic acid: metabotropic glutamate receptor agonism and effects on long-term potentiation. Neuroscience 72 999 PMID: 8735225
Takeda et al (2007) Role of zinc influx via AMPA/Kainate receptor activation in metabotropic glutamate receptor-mediated calcium release. J.Neurosci.Res. 85 1310 PMID: 17304583
Keywords: tADA, tADA supplier, Group, I, agonists, mGlu5, mGluR5, selectivity, Receptors, mGlu1, mGluR1, Glutamate, Metabotropic, (Metabotropic), 0860, Tocris Bioscience
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