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Discontinued Product
tADA (Cat. No. 0860) has been withdrawn from sale for commercial reasons.
Description: Group I agonist; some mGlu5 selectivity
Chemical Name: trans-Azetidine-2,4-dicarboxylic acid
Biological Activity for tADA
Group I selective metabotropic glutamate receptor agonist. More potent at mGlu5a than mGlu1a in LLC-PKI cells and induces calcium release in CA3 pyramidal cells in vitro.
Technical Data for tADA
| M. Wt | 145.11 |
| Formula | C5H7NO4 |
| Storage | Store at RT |
| CAS Number | 161596-62-9 |
| Smiles | O=[C@@]([C@@H]1C[C@@H]([C@@](O)=O)N1)O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for tADA
References for tADA
References are publications that support the biological activity of the product.
Kozikowski et al (1993) Synthesis and metabotropic receptor activity of the novel rigidified glutamate analogues (+) and (-)-trans-azetidine-2,4,-dicarboxylic acid and their N-methyl derivatives. J.Med.Chem. 36 2706 PMID: 8410984
Manahan-Vaughan et al (1996) Physiological and pharmalogical profile of trans-azetidine-2,4-dicarboxylic acid: metabotropic glutamate receptor agonism and effects on long-term potentiation. Neuroscience 72 999 PMID: 8735225
Takeda et al (2007) Role of zinc influx via AMPA/Kainate receptor activation in metabotropic glutamate receptor-mediated calcium release. J.Neurosci.Res. 85 1310 PMID: 17304583
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Keywords: tADA, tADA supplier, Group, I, agonists, mGlu5, mGluR5, selectivity, Receptors, mGlu1, mGluR1, Glutamate, Metabotropic, (Metabotropic), 0860, Tocris Bioscience
Citations for tADA
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Currently there are no citations for tADA.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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Huntington's Disease Poster
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.
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