T 3364366

Pricing Availability   Qty
Cat.No. 6106 - T 3364366 | C18H16F3N3O3S2 | CAS No. 1356354-09-0
Description: Potent and reversible fatty acid desaturase 1 inhibitor; orally bioavailable
Chemical Name: N-[2-[[3,4-Dihydro-4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]thieno[3,4-d]pyrimidin-2-yl]thio]ethyl]acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and reversible fatty acid desaturase 1 (FADS1; Δ5 desaturase) inhibitor (IC50 values are 1.9 nM and 2.1 nM in human and rat hepatocyte cell lines, respectively). Exhibits >300 fold selectivity for FADS1 over FADS2 (Δ6 desaturase). Inhibits arachidonic acid production in rat and human hepatocyte cell lines. Orally bioavailable.

Technical Data

M. Wt 443.46
Formula C18H16F3N3O3S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1356354-09-0
PubChem ID 86685411
InChI Key BVRXQXNVDLUWMV-UHFFFAOYSA-N
Smiles CC(NCCSC1=NC2=CSC=C2C(N1C3=CC=C(C=C3)OCC(F)(F)F)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.35 100

Preparing Stock Solutions

The following data is based on the product molecular weight 443.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.25 mL 11.27 mL 22.55 mL
5 mM 0.45 mL 2.25 mL 4.51 mL
10 mM 0.23 mL 1.13 mL 2.25 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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References

References are publications that support the biological activity of the product.

Miyahisa et al (2016) T-3364366 targets the desaturase domain of delta-5 desaturase with nanomolar potency and a multihour residence time. ACS Med.Chem.Lett. 7 868 PMID: 27660693


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Keywords: T 3364366, T 3364366 supplier, T3364366, FADS1, inhibitors, inhibits, potent, reversible, delta5, desaturase, arachidonic, acid, anti-inflammatory, acyl-lipid(8-3), Other, Lipid, Metabolism, Oxygenases/Oxidases, 6106, Tocris Bioscience

Citations for T 3364366

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