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Submit ReviewT 26c disodium salt
Description: Highly potent and selective MMP13 inhibitor
Chemical Name: Disodium 4-[[[[2-[[[[3-(Methyloxy)phenyl]methyl]amino]carbonyl]-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl]methyl]oxy]methyl]benzoate
Purity: ≥98% (HPLC)
Biological Activity for T 26c disodium salt
T 26c disodium salt is a highly potent and selective MMP13 inhibitor (IC50 = 6.9 pM). Exhibits >2600-fold selectivity for MMP13 over related MMPs. Inhibits degradation of bovine nasal septum cartilage explants in vitro . Orally bioavailable.
Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the T-26c probe summary on the SGC website.
Technical Data for T 26c disodium salt
| M. Wt | 523.47 |
| Formula | C24H19N3Na2O6S |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 869298-22-6 |
| PubChem ID | 131954584 |
| InChI Key | MJSVEIMIMXVRNJ-UHFFFAOYSA-L |
| Smiles | COC1=CC=CC(CNC(C2=NC(C3=C(SC=C3COCC4=CC=C(C(O[Na])=O)C=C4)N2[Na])=O)=O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for T 26c disodium salt
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5.23 | 10 with gentle warming | |
| water | 0.52 | 1 |
Preparing Stock Solutions for T 26c disodium salt
The following data is based on the product molecular weight 523.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.1 mL | 95.52 mL | 191.03 mL |
| 0.5 mM | 3.82 mL | 19.1 mL | 38.21 mL |
| 1 mM | 1.91 mL | 9.55 mL | 19.1 mL |
| 5 mM | 0.38 mL | 1.91 mL | 3.82 mL |
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Product Datasheets for T 26c disodium salt
References for T 26c disodium salt
References are publications that support the biological activity of the product.
Nara et al (2014) Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1" binding site. Bioorg.Med.Chem. 22 5487 PMID: 25192810
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