T 26c disodium salt

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Cat.No. 6134 - T 26c disodium salt | C24H19N3Na2O6S | CAS No. 869298-22-6
Description: Highly potent and selective MMP13 inhibitor
Chemical Name: Disodium 4-[[[[2-[[[[3-(Methyloxy)phenyl]methyl]amino]carbonyl]-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl]methyl]oxy]methyl]benzoate
Purity: ≥98% (HPLC)

Biological Activity

Highly potent and selective MMP13 inhibitor (IC50 = 6.9 pM). Exhibits >2600-fold selectivity for MMP13 over related MMPs. Inhibits degradation of bovine nasal septum cartilage explants in vitro . Orally bioavailable.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the T-26c probe summary on the SGC website.

Technical Data

M. Wt 523.47
Formula C24H19N3Na2O6S
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 869298-22-6
Smiles COC1=CC=CC(CNC(C2=NC(C3=C(SC=C3COCC4=CC=C(C(O[Na])=O)C=C4)N2[Na])=O)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 5.23 10mM with gentle warming
water 0.52 1

Preparing Stock Solutions

The following data is based on the product molecular weight 523.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.91 mL 9.55 mL 19.1 mL
5 mM 0.38 mL 1.91 mL 3.82 mL
10 mM 0.19 mL 0.96 mL 1.91 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Nara et al (2014) Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1" binding site. Bioorg.Med.Chem. 22 5487 PMID: 25192810

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