T 26c disodium salt

Pricing Availability   Qty
Description: Highly potent and selective MMP13 inhibitor
Chemical Name: Disodium 4-[[[[2-[[[[3-(Methyloxy)phenyl]methyl]amino]carbonyl]-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl]methyl]oxy]methyl]benzoate
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for T 26c disodium salt

T 26c disodium salt is a highly potent and selective MMP13 inhibitor (IC50 = 6.9 pM). Exhibits >2600-fold selectivity for MMP13 over related MMPs. Inhibits degradation of bovine nasal septum cartilage explants in vitro . Orally bioavailable.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the T-26c probe summary on the SGC website.

Technical Data for T 26c disodium salt

M. Wt 523.47
Formula C24H19N3Na2O6S
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 869298-22-6
PubChem ID 131954584
Smiles COC1=CC=CC(CNC(C2=NC(C3=C(SC=C3COCC4=CC=C(C(O[Na])=O)C=C4)N2[Na])=O)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for T 26c disodium salt

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 5.23 10 with gentle warming
water 0.52 1

Preparing Stock Solutions for T 26c disodium salt

The following data is based on the product molecular weight 523.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.1 mL 95.52 mL 191.03 mL
0.5 mM 3.82 mL 19.1 mL 38.21 mL
1 mM 1.91 mL 9.55 mL 19.1 mL
5 mM 0.38 mL 1.91 mL 3.82 mL

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Product Datasheets for T 26c disodium salt

References for T 26c disodium salt

References are publications that support the biological activity of the product.

Nara et al (2014) Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1" binding site. Bioorg.Med.Chem. 22 5487 PMID: 25192810

If you know of a relevant reference for T 26c disodium salt, please let us know.

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Citations for T 26c disodium salt

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